Phenylacetylglutamine as a novel biomarker of type 2 diabetes with distal symmetric polyneuropathy by metabolomics

Terkelsen AJ, Karlsson P, Lauria G, Freeman R, Finnerup NB, Jensen TS (2017) The diagnostic challenge of small fibre neuropathy: clinical presentations, evaluations, and causes. Lancet Neurol 16(11):934–944

Article  PubMed  Google Scholar 

Galiero R, Ricciardi D, Pafundi PC (2021) Whole plantar nerve conduction study: a new tool for early diagnosis of peripheral diabetic neuropathy. Diabetes Res Clin Pract 176:108856

Article  PubMed  Google Scholar 

Boulton AJ, Vinik AI, Arezzo JC, Bril V, Feldman EL, Freeman R, Malik RA, Maser RE, Sosenko JM, Ziegler D, American Diabetes A (2005) Diabetic neuropathies: a statement by the American Diabetes Association. Diabetes Care 28(4):956–962

Article  PubMed  Google Scholar 

Ismail-Beigi F, Craven T, Banerji MA, Basile J, Calles J, Cohen RM, Cuddihy R, Cushman WC, Genuth S et al (2010) Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial. Lancet 376(9739):419–430

Article  PubMed  PubMed Central  Google Scholar 

Pop-Busui R, Boulton AJ, Feldman EL, Bril V, Freeman R, Malik RA, Sosenko JM, Ziegler D (2017) Diabetic neuropathy: a position statement by the American Diabetes Association. Diabetes Care 40(1):136–154

Article  CAS  PubMed  Google Scholar 

Chalk C, Benstead TJ, Moore F (2007) Aldose reductase inhibitors for the treatment of diabetic polyneuropathy. Cochrane Database Syst Rev 2007(4):CD004572

PubMed  PubMed Central  Google Scholar 

Humpert PM, Papadopoulos G, Schaefer K, Djuric Z, Konrade I, Morcos M, Nawroth PP, Bierhaus A (2007) sRAGE and esRAGE are not associated with peripheral or autonomic neuropathy in type 2 diabetes. Horm Metab Res 39(12):899–902

Article  CAS  PubMed  Google Scholar 

Vinik AI, Bril V, Kempler P, Litchy WJ, Tesfaye S, Price KL, Bastyr EJ 3rd, Group MS (2005) Treatment of symptomatic diabetic peripheral neuropathy with the protein kinase C beta-inhibitor ruboxistaurin mesylate during a 1-year, randomized, placebo-controlled, double-blind clinical trial. Clin Ther 27(8):1164–1180

Article  CAS  PubMed  Google Scholar 

Jin HY, Joung SJ, Park JH, Baek HS, Park TS (2007) The effect of alpha-lipoic acid on symptoms and skin blood flow in diabetic neuropathy. Diabet Med 24(9):1034–1038

Article  CAS  PubMed  Google Scholar 

Rinschen MM, Ivanisevic J, Giera M, Siuzdak G (2019) Identification of bioactive metabolites using activity metabolomics. Nat Rev Mol Cell Biol 20(6):353–367

Article  CAS  PubMed  PubMed Central  Google Scholar 

American Diabetes Association (2020) 2. Classification and diagnosis of diabetes: standards of medical care in diabetes-2020. Diabetes Care 43(Suppl 1):S14–S31

Article  Google Scholar 

Bril V, Perkins BA (2002) Validation of the Toronto Clinical Scoring System for diabetic polyneuropathy. Diabetes Care 25(11):2048–2052

Article  PubMed  Google Scholar 

Tarca AL, Lauria M, Unger M, Bilal E, Boue S, Kumar Dey K, Hoeng J, Koeppl H, Martin F, Meyer P et al (2013) Strengths and limitations of microarray-based phenotype prediction: lessons learned from the IMPROVER Diagnostic Signature Challenge. Bioinformatics 29(22):2892–2899

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tan YM, Gao Y, Teo G, Koh HWL, Tai ES, Khoo CM, Choi KP, Zhou L, Choi H (2021) Plasma metabolome and lipidome associations with type 2 diabetes and diabetic nephropathy. Metabolites 11(4):228

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luo P, Yin P, Hua R, Tan Y, Li Z, Qiu G, Yin Z, Xie X, Wang X, Chen W, Zhou L, Wang X, Li Y, Chen H, Gao L, Lu X, Wu T, Wang H, Niu J, Xu G (2018) A large-scale, multicenter serum metabolite biomarker identification study for the early detection of hepatocellular carcinoma. Hepatology 67(2):662–675

Article  CAS  PubMed  Google Scholar 

Zhang HH, Han X, Wang M, Hu Q, Li S, Wang M, Hu J (2019) The association between genomic DNA methylation and diabetic peripheral neuropathy in patients with type 2 diabetes mellitus. J Diabetes Res 2019:2494057

Article  PubMed  PubMed Central  Google Scholar 

Nemet I, Saha PP, Gupta N, Zhu W, Romano KA, Skye SM, Cajka T, Mohan ML, Li L, Wu Y, Funabashi M, Ramer-Tait AE, Naga Prasad SV, Fiehn O, Rey FE, Tang WHW, Fischbach MA, DiDonato JA, Hazen SL (2020) A cardiovascular disease-linked gut microbial metabolite acts via adrenergic receptors. Cell 180(5):862 e822-877 e822

Article  Google Scholar 

Dodd D, Spitzer MH, Van Treuren W, Merrill BD, Hryckowian AJ, Higginbottom SK, Le A, Cowan TM, Nolan GP, Fischbach MA, Sonnenburg JL (2017) A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites. Nature 551(7682):648–652

Article  CAS  PubMed  PubMed Central  Google Scholar 

Feldman EL, Nave KA, Jensen TS, Bennett DLH (2017) New horizons in diabetic neuropathy: mechanisms, bioenergetics, and pain. Neuron 93(6):1296–1313

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo K, Savelieff MG, Rumora AE, Alakwaa FM, Callaghan BC, Hur J, Feldman EL (2022) Plasma metabolomics and lipidomics differentiate obese individuals by peripheral neuropathy status. J Clin Endocrinol Metab 107(4):1091–1109

Article  PubMed  Google Scholar 

Rumora AE, Guo K, Alakwaa FM, Andersen ST, Reynolds EL, Jorgensen ME, Witte DR, Tankisi H, Charles M, Savelieff MG, Callaghan BC, Jensen TS, Feldman EL (2021) Plasma lipid metabolites associate with diabetic polyneuropathy in a cohort with type 2 diabetes. Ann Clin Transl Neurol 8(6):1292–1307

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hinder LM, Vivekanandan-Giri A, McLean LL, Pennathur S, Feldman EL (2013) Decreased glycolytic and tricarboxylic acid cycle intermediates coincide with peripheral nervous system oxidative stress in a murine model of type 2 diabetes. J Endocrinol 216(1):1–11

Article  CAS  PubMed  PubMed Central  Google Scholar 

Warren BE, Lou PH, Lucchinetti E, Zhang L, Clanachan AS, Affolter A, Hersberger M, Zaugg M, Lemieux H (2014) Early mitochondrial dysfunction in glycolytic muscle, but not oxidative muscle, of the fructose-fed insulin-resistant rat. Am J Physiol Endocrinol Metab 306(6):E658-667

Article  CAS  PubMed  PubMed Central  Google Scholar 

Williams-Ashman HG, Seidenfeld J, Galletti P (1982) Trends in the biochemical pharmacology of 5′-deoxy-5′-methylthioadenosine. Biochem Pharmacol 31(3):277–288

Article  CAS  PubMed  Google Scholar 

Tam ZY, Ng SP, Tan LQ, Lin CH, Rothenbacher D, Klenk J, Boehm BO, Team SPC, Acti FESG (2017) Metabolite profiling in identifying metabolic biomarkers in older people with late-onset type 2 diabetes mellitus. Sci Rep 7(1):4392

Article  PubMed  PubMed Central  Google Scholar 

Moreno B, Lopez I, Fernandez-Diez B, Gottlieb M, Matute C, Sanchez-Gomez MV, Domercq M, Giralt A, Alberch J, Collon KW, Zhang H, Parent JM, Teixido M, Giralt E, Cena V, Posadas I, Martinez-Pinilla E, Villoslada P, Franco R (2014) Differential neuroprotective effects of 5′-deoxy-5′-methylthioadenosine. PLoS ONE 9(3):e90671

Article  PubMed  PubMed Central  Google Scholar 

Ottosson F, Smith E, Fernandez C, Melander O (2020) Plasma metabolites associate with all-cause mortality in individuals with type 2 diabetes. Metabolites 10(8):315

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elkordy A, Mishima E, Niizuma K, Akiyama Y, Fujimura M, Tominaga T, Abe T (2018) Stress-induced tRNA cleavage and tiRNA generation in rat neuronal PC12 cells. J Neurochem 146(5):560–569

Article  CAS  PubMed  Google Scholar 

Ju L, Wen Y, Yin J, Deng S, Zheng J, Wang L, Deng H, Hou Z, Zhao X, He S, Huang L, Zhang C, Tian G, Meng Z, Li Y (2016) Metabonomic study of the effects of different acupuncture directions on therapeutic efficacy. J Chromatogr B Analyt Technol Biomed Life Sci 1009–1010:87–95

Article  PubMed  Google Scholar 

Lo Verme J, Fu J, Astarita G, La Rana G, Russo R, Calignano A, Piomelli D (2005) The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide. Mol Pharmacol 67(1):15–19

Article  CAS  PubMed  Google Scholar 

Guzman M, Lo Verme J, Fu J, Oveisi F, Blazquez C, Piomelli D (2004) Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-alpha). J Biol Chem 279(27):27849–27854

Article  CAS  PubMed  Google Scholar 

Hansen HS (2010) Palmitoylethanolamide and other anandamide congeners. Proposed role in the diseased brain. Exp Neurol 224(1):48–55

Article  CAS  PubMed  Google Scholar 

Altamura C, Ventriglia M, Martini MG, Montesano D, Errante Y, Piscitelli F, Scrascia F, Quattrocchi C, Palazzo P, Seccia S, Vernieri F, Di Marzo V (2015) Elevation of plasma 2-arachidonoylglycerol levels in Alzheimer’s disease patients as a potential protective mechanism against neurodegenerative decline. J Alzheimers Dis 46(2):497–506

Article  CAS  PubMed  Google Scholar 

Greene DA (1986) Sorbitol, myo-inositol and sodium-potassium ATPase in diabetic peripheral nerve. Drugs 32(Suppl 2):6–14

Article  CAS  PubMed 

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