Neurogenic Background for Emotional Stress-Associated Hypertension

Tsao CW, Aday AW, Almarzooq ZI, Alonso A, Beaton AZ, Bittencourt MS, et al. Heart disease and stroke statistics—2022 update: a report from the American Heart Association. Circulation. 2022;145(8):e153-639.

Article  PubMed  Google Scholar 

Nations U. revision of world urbanization prospects. United Nations Department of Economic and Social Affairs. 2018;

Szabo CP. Urbanization and mental health: a developing world perspective. Curr Opin Psychiatry. 2018;31(3):256–7.

Article  PubMed  Google Scholar 

Zhou B, Carrillo-Larco RM, Danaei G, Riley LM, Paciorek CJ, Stevens GA, et al. Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. The Lancet. 2021;398(10304):957–80.

Article  Google Scholar 

Esler M. Mental stress and human cardiovascular disease. Neurosci Biobehav Rev. 2017;74:269–76.

Article  PubMed  Google Scholar 

• Johnson HM. Anxiety and hypertension: is there a link? A literature review of the comorbidity relationship between anxiety and hypertension. Curr Hypertens Rep. 2019;21(9):1–7. Shows that there is a positive association between comorbid anxiety and hypertension.

Article  Google Scholar 

Khera R, Light-McGroary K, Zahr F, Horwitz PA, Girotra S. Trends in hospitalization for takotsubo cardiomyopathy in the United States. Am Heart J. 2016;172:53–63.

Article  PubMed  Google Scholar 

Spruill TM. Chronic psychosocial stress and hypertension. Curr Hypertens Rep. 2010;12(1):10–6.

Article  PubMed  PubMed Central  Google Scholar 

Shah SMA, Mohammad D, Qureshi MFH, Abbas MZ, Aleem S. Prevalence, Psychological Responses and associated correlates of depression, anxiety and stress in a global population, during the coronavirus disease (COVID-19) pandemic. Commun Ment Health J. 2021;57(1):101–10.

Article  PubMed  Google Scholar 

Borg BA, Rabinak CA, Marusak HA. Violence exposure and mental health consequences among urban youth. Curr Psychol. 2021;1–10.

Ventimiglia I, Seedat S. Current evidence on urbanicity and the impact of neighbourhoods on anxiety and stress-related disorders. Curr Opin Psychiat. 2019;32(3):248–53.

Article  PubMed  Google Scholar 

Bandelow B, Michaelis S, Wedekind D. Treatment of anxiety disorders. Dialog Clin Neurosci. 2017;19(2):93.

Article  PubMed  PubMed Central  Google Scholar 

de Silva T, Cosentino G, Ganji S, Riera-Gonzalez A, Hsia DS. Endocrine causes of hypertension. Curr Hypertens Rep. 2020;22(11):1–13.

Article  Google Scholar 

Saxena T, Ali AO, Saxena M. Pathophysiology of essential hypertension: an update. Expert Rev Cardiovasc Ther. 2018;16(12):879–87.

Article  CAS  PubMed  Google Scholar 

Hahad O, Beutel M, Gori T, Schulz A, Blettner M, Pfeiffer N, et al. Annoyance to different noise sources is associated with atrial fibrillation in the Gutenberg Health Study. Int J Cardiol. 2018;264:79–84.

Article  PubMed  Google Scholar 

Trudel X, Brisson C, Gilbert-Ouimet M, Milot A. Psychosocial stressors at work and ambulatory blood pressure. Curr Cardiol Rep. 2018;20(12):1–9.

Article  Google Scholar 

Zeeb H, Hegewald J, Schubert M, Wagner M, Dröge P, Swart E, et al. Traffic noise and hypertension–results from a large case-control study. Environ Res. 2017;157:110–7.

Article  CAS  PubMed  Google Scholar 

Carter JR, Goldstein DS. Sympathoneural and adrenomedullary responses to mental stress. Compr Physiol. 2015;5(1):119.

PubMed  PubMed Central  Google Scholar 

da Silva AQG, Xavier CH, Campagnole-Santos MJ, Caligiorne SM, Baltatu OC, Bader M, et al. Cardiovascular responses evoked by activation or blockade of GABAA receptors in the hypothalamic PVN are attenuated in transgenic rats with low brain angiotensinogen. Brain Res. 2012;1448:101–10.

Article  Google Scholar 

Saavedra JM, Benicky J. Brain and peripheral angiotensin II play a major role in stress. Stress. 2007;10(2):185–93.

Article  CAS  PubMed  Google Scholar 

• Armstrong C, Kapolowicz MR. A preliminary investigation on the effects of atenolol for treating symptoms of anxiety. Mil Med. 2020;185(11–12):e1954–60. This study suggests that the beta-blocker atenolol may be well-tolerated and effective among persons with anxiety disorders.

• Lee DL, Webb RC, Brands MW. Sympathetic and angiotensin-dependent hypertension during cage-switch stress in mice. Am J Physiol-Regul Integrat Compar Physiol. 2004;287(6):R1394–8. (This study shows that atenolol only moderately attenuates the tachycardic effect to acute stress and had no effect to blunt the initial increase in MAP.)

Lambert E, Dawood T, Straznicky N, Sari C, Schlaich M, Esler M, et al. Association between the sympathetic firing pattern and anxiety level in patients with the metabolic syndrome and elevated blood pressure. J Hypertens. 2010;28(3):543–50.

Article  CAS  PubMed  Google Scholar 

Holwerda SW, Luehrs RE, Gremaud AL, Wooldridge NA, Stroud AK, Fiedorowicz JG, et al. Relative burst amplitude of muscle sympathetic nerve activity is an indicator of altered sympathetic outflow in chronic anxiety. J Neurophysiol. 2018;120(1):11–22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

El Sayed K, Macefield VG, Hissen SL, Joyner MJ, Taylor CE. Blood pressure reactivity at onset of mental stress determines sympathetic vascular response in young adults. Physiol Rep. 2018;6(24): e13944.

Article  PubMed  PubMed Central  Google Scholar 

Krmar RT. White-coat hypertension from a paediatric perspective. Acta Paediatr. 2019;108(1):44–9.

Article  PubMed  Google Scholar 

Smith PA, Graham LN, Mackintosh AF, Stoker JB, Mary DA. Sympathetic neural mechanisms in white-coat hypertension. J Am Coll Cardiol. 2002;40(1):126–32.

Article  PubMed  Google Scholar 

Bonnet L, Comte A, Tatu L, Millot JL, Moulin T, Medeiros de Bustos E. The role of the amygdala in the perception of positive emotions: an “intensity detector”. Front Behav Neurosci. 2015;9:178.

Namburi P, Al-Hasani R, Calhoon GG, Bruchas MR, Tye KM. Architectural representation of valence in the limbic system. Neuropsychopharmacology. 2016;41(7):1697–715.

Article  PubMed  PubMed Central  Google Scholar 

Fontes MAP, Filho ML, Machado NLS, Paula CA de, Cordeiro LMS, Xavier CH, et al. Asymmetric sympathetic output: The dorsomedial hypothalamus as a potential link between emotional stress and cardiac arrhythmias. Autonomic Neuroscience: Basic and Clinical. 1° de novembro de 2017;207:22–7.

Henderson LA, Macefield VG. The role of the dorsomedial and ventromedial hypothalamus in regulating behaviorally coupled and resting autonomic drive. Em: Handbook of Clinical Neurology. Elsevier. 2021;187–200.

Dampney RAL, Coleman MJ, Fontes MAP, Hirooka Y, Horiuchi J, Li YW, et al. Central mechanisms underlying short-and long-term regulation of the cardiovascular system. Clin Exp Pharmacol Physiol. 2002;29(4):261–8.

Article  CAS  PubMed  Google Scholar 

Guyenet PG. The sympathetic control of blood pressure. Nat Rev Neurosci. 2006;7(5):335–46.

Article  CAS  PubMed  Google Scholar 

Shafton AD, Ryan A, Badoer E. Neurons in the hypothalamic paraventricular nucleus send collaterals to the spinal cord and to the rostral ventrolateral medulla in the rat. Brain Res. 1998;801(1–2):239–43.

Article  CAS  PubMed  Google Scholar 

Zheng H, Katsurada K, Nandi S, Li Y, Patel KP. A critical role for the paraventricular nucleus of the hypothalamus in the regulation of the volume reflex in normal and various cardiovascular disease states. Curr Hyperten Rep. 2022;1–12.

Zhang K, Li YF, Patel KP. Reduced endogenous GABA-mediated inhibition in the PVN on renal nerve discharge in rats with heart failure. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 2002;282(4):R1006–15.

Article  CAS  PubMed  Google Scholar 

• Kataoka N, Shima Y, Nakajima K, Nakamura K. A central master driver of psychosocial stress responses in the rat. Science. 2020;367(6482):1105–12. Points out the DMH as a key relay of a central master neural pathway that drives autonomic and behavioral stress responses.

Calhoon GG, Tye KM. Resolving the neural circuits of anxiety. Nat Neurosci. 2015;18(10):1394–404.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Canli T, Zhao Z, Brewer J, Gabrieli JD, Cahill L. Event-related activation in the human amygdala associates with later memory for individual emotional experience. J Neurosci. 2000;20(19):RC99–RC99.

Taylor SF, Liberzon I, Koeppe RA. The effect of graded aversive stimuli on limbic and visual activation. Neuropsychologia. 2000;38(10):1415–25.

Article  CAS  PubMed  Google Scholar 

• Ressler K, Berretta S, Bolshakov VY, Rosso IM, Meloni EG, Rauch SL, et al. Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits. Nat Rev Neurol. 2022;18(5):273–88. Shows that individuals with PTSD present significantly more amygdala activation in response to negative emotional stimuli and greater sympathetic responses when compared to control individuals.

Brudey C, Park J, Wiaderkiewicz J, Kobayashi I, Mellman TA, Marvar PJ. Autonomic and inflammatory consequences of posttraumatic stress disorder and the link to cardiovascular disease. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 2015;309(4):R315–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fiechter M, Roggo A, Burger IA, Bengs S, Treyer V, Becker A, et al. Association between resting amygdalar activity and abnormal cardiac function in women and men: a retrospective cohort study. European Heart Journal-Cardiovascular Imaging. 2019;20(6):625–32.

Article  PubMed  Google Scholar 

Vaccarino V, Bremner JD. Behavioral, emotional and neurobiological determinants of coronary heart disease risk in women. Neurosci Biobehav Rev. 2017;74:297–309.

Article  PubMed  Google Scholar 

Chen Z, Liu N, Xiao J, Wang Y, Dong R. The amygdala via the paraventricular nucleus regulates asthma attack in rats. CNS Neurosci Ther. 2020;26(7):730–40.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tovote P, Fadok JP, Lüthi A. Neuronal circuits for fear and anxiety. Nat Rev Neurosci. 2015;16(6):317–31.

Article  CAS  PubMed  Google Scholar 

Schaeuble D, Myers B. Cortical–hypothalamic integration of autonomic and endocrine stress responses. Front Physiol. 2022;151.

Holper L, Burke CJ, Fausch C, Seifritz E, Tobler PN. Inequality signals in dorsolateral prefrontal cortex inform social preference models. Social Cognitive and Affective Neuroscience. 2018;13(5):513–24.

Article  PubMed  PubMed Central 

留言 (0)

沒有登入
gif