A.D. has been an advisory board member for Amgen, Foundation Medicine and Sanofi. H.J.W. has been an advisory board member for Amgen, AstraZeneca, Boehringer–Ingelheim, Bristol Myers Squibb, Celgene, Eli Lilly, Genentech/Roche, Merck, Mirati, Regeneron, Summit Therapeutics and Takeda. C.J.S. declares no competing interests.