Coontz, R. & Hanson, B. Not so simple. Science 305, 957 (2004).

Article  CAS  Google Scholar 

Barkai, E., Jung, Y. J. & Silbey, R. Theory of single-molecule spectroscopy: beyond the ensemble average. Annu. Rev. Phys. Chem. 55, 457–507 (2004).

Article  CAS  PubMed  Google Scholar 

Zrimsek, A. B. et al. Single-molecule chemistry with surface- and tip-enhanced Raman spectroscopy. Chem. Rev. 117, 7583–7613 (2017).

Article  CAS  PubMed  Google Scholar 

Lu, H. P., Xun, L. & Xie, X. S. Single-molecule enzymatic dynamics. Science 282, 1877–1882 (1998).

Article  CAS  PubMed  Google Scholar 

Liu, C. et al. Single polymer growth dynamics. Science 358, 352–355 (2017).

Article  CAS  PubMed  Google Scholar 

Florin, E. L., Moy, V. T. & Gaub, H. E. Adhesion forces between individual ligand-receptor pairs. Science 264, 415–417 (1994).

Article  CAS  PubMed  Google Scholar 

Li, Y., Yang, C. & Guo, X. Single-molecule electrical detection: a promising route toward the fundamental limits of chemistry and life science. Acc. Chem. Res. 53, 159–169 (2020).

Article  CAS  PubMed  Google Scholar 

Xin, N. et al. Concepts in the design and engineering of single-molecule electronic devices. Nat. Rev. Phys. 1, 211–230 (2019).

Article  Google Scholar 

Venkatesan, B. M. & Bashir, R. Nanopore sensors for nucleic acid analysis. Nat. Nanotechnol. 6, 615–624 (2011).

Article  CAS  PubMed  Google Scholar 

Aviram, A. & Ratner, M. A. Molecular rectifiers. Chem. Phys. Lett. 29, 277–283 (1974).

Article  CAS  Google Scholar 

Xiang, D., Wang, X., Jia, C., Lee, T. & Guo, X. Molecular-scale electronics: from concept to function. Chem. Rev. 116, 4318–4440 (2016).

Article  CAS  PubMed  Google Scholar 

Li, T., Hu, W. & Zhu, D. Nanogap electrodes. Adv. Mater. 22, 286–300 (2010).

Article  PubMed  Google Scholar 

Jia, C. & Guo, X. Molecule-electrode interfaces in molecular electronic devices. Chem. Soc. Rev. 42, 5642–5660 (2013).

Article  CAS  PubMed  Google Scholar 

Su, T. A., Neupane, M., Steigerwald, M. L., Venkataraman, L. & Nuckolls, C. Chemical principles of single-molecule electronics. Nat. Rev. Mater. 1, 16002 (2016).

Article  CAS  Google Scholar 

Xu, B. & Tao, N. Measurement of single-molecule resistance by repeated formation of molecular junctions. Science 301, 1221–1223 (2003).

Article  CAS  PubMed  Google Scholar 

Venkataraman, L., Klare, J. E., Nuckolls, C., Hybertsen, M. S. & Steigerwald, M. L. Dependence of single-molecule junction conductance on molecular conformation. Nature 442, 904–907 (2006).

Article  CAS  PubMed  Google Scholar 

Reed, M. A., Zhou, C., Muller, C. J., Burgin, T. P. & Tour, J. M. Conductance of a molecular junction. Science 278, 252–254 (1997).

Article  CAS  Google Scholar 

Park, H., Lim, A. K. L., Alivisatos, A. P., Park, J. & McEuen, P. L. Fabrication of metallic electrodes with nanometer separation by electromigration. Appl. Phys. Lett. 75, 301–303 (1999).

Article  CAS  Google Scholar 

Park, J. et al. Coulomb blockade and the Kondo effect in single-atom transistors. Nature 417, 722–725 (2002).

Article  CAS  PubMed  Google Scholar 

Gehring, P. et al. Field-effect control of graphene–fullerene thermoelectric nanodevices. Nano Lett. 17, 7055–7061 (2017).

Article  CAS  PubMed  Google Scholar 

Burzurí, E. et al. Sequential electron transport and vibrational excitations in an organic molecule coupled to few-layer graphene electrodes. ACS Nano 10, 2521–2527 (2016).

Article  PubMed  Google Scholar 

Burzurí, E. et al. Spin-state dependent conductance switching in single molecule-graphene junctions. Nanoscale 10, 7905–7911 (2018).

Article  PubMed  Google Scholar 

Island, J. O. et al. Fabrication of hybrid molecular devices using multi-layer graphene break junctions. J. Phys. Condens. Matter 26, 474205 (2014).

Article  CAS  PubMed  Google Scholar 

Prins, F. et al. Room-temperature gating of molecular junctions using few-layer graphene nanogap electrodes. Nano Lett. 11, 4607–4611 (2011).

Article  CAS  PubMed  Google Scholar 

Lau, C. S. et al. Redox-dependent Franck–Condon blockade and avalanche transport in a graphene-fullerene single-molecule transistor. Nano Lett. 16, 170–176 (2015).

Article  PubMed  Google Scholar 

Limburg, B. et al. Anchor groups for graphene-porphyrin single-molecule transistors. Adv. Funct. Mater. 28, 1803629 (2018).

Article  Google Scholar 

Mol, J. A. et al. Graphene-porphyrin single-molecule transistors. Nanoscale 7, 13181–13185 (2015).

Article  CAS  PubMed  Google Scholar 

Thomas, J. O. et al. Understanding resonant charge transport through weakly coupled single-molecule junctions. Nat. Commun. 10, 4628 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Pei, T. et al. Exchange-induced spin polarization in a single magnetic molecule junction. Nat. Commun. 13, 4506 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao, S. et al. Charge transport through single-molecule bilayer-graphene junctions with atomic thickness. Chem. Sci. 13, 5854–5859 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cao, Y. et al. Building high-throughput molecular junctions using indented graphene point contacts. Angew. Chem. Int. Ed. Engl. 51, 12228–12232 (2012).

Article  CAS  PubMed  Google Scholar 

Gu, C. H., Su, D. K., Jia, C. C., Ren, S. Z. & Guo, X. F. Building nanogapped graphene electrode arrays by electroburning. RSC Adv. 8, 6814–6819 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo, X. et al. Covalently bridging gaps in single-walled carbon nanotubes with conducting molecules. Science 311, 356–359 (2006).

Article  CAS  PubMed  Google Scholar 

Jia, C. et al. Covalently bonded single-molecule junctions with stable and reversible photoswitched conductivity. Science 352, 1443–1445 (2016).

Article  CAS  PubMed  Google Scholar 

Jia, C., Ma, B., Xin, N. & Guo, X. Carbon electrode-molecule junctions: a reliable platform for molecular electronics. Acc. Chem. Res. 48, 2565–2575 (2015).

Article  CAS  PubMed  Google Scholar 

Xin, N. et al. Stereoelectronic effect-induced conductance switching in aromatic chain single-molecule junctions. Nano Lett. 17, 856–861 (2017).

Article  CAS  PubMed  Google Scholar 

Meng, L. et al. Atomically precise engineering of single-molecule stereoelectronic effect. Angew. Chem. Int. Ed. Engl. 60, 12274–12278 (2021).

Article  CAS  PubMed  Google Scholar 

Yang, C. et al. Complete deciphering of the dynamic stereostructures of a single aggregation-induced emission molecule. Matter 5, 1224–1234 (2022).

Article  CAS  Google Scholar 

Wen, H. et al. Complex formation dynamics in a single-molecule electronic device. Sci. Adv. 2, e1601113 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Zhou, C. et al. Direct observation of single-molecule hydrogen-bond dynamics with single-bond resolution. Nat. Commun. 9, 807 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Liu, Z. et al. A single-molecule electrical approach for amino acid detection and chirality recognition. Sci. Adv. 7, eabe4365 (2021).

Article  CAS