Funder JW, Carey RM, Mantero F, Murad MH, Reincke M, Shibata H et al (2016) The management of primary aldosteronism: case detection, diagnosis, and treatment: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 101:1889–1916. https://doi.org/10.1210/jc.2015-4061

Article  CAS  PubMed  Google Scholar 

Conn JW (1965) Hypertension, the potassium ion and impaired carbohydrate tolerance. N Engl J Med 273:1135–1143. https://doi.org/10.1056/NEJM196511182732106

Article  CAS  PubMed  Google Scholar 

Akehi Y, Yanase T, Motonaga R, Umakoshi H, Tsuiki M, Takeda Y et al (2019) High prevalence of diabetes in patients with primary aldosteronism (PA) associated with subclinical hypercortisolism and prediabetes more prevalent in bilateral than unilateral PA: a large. Multicenter Cohort Study in Japan 42:938–945

CAS  Google Scholar 

Adler GK, Murray GR, Turcu AF, Nian H, Yu C, Solorzano CC et al (2020) Primary Aldosteronism decreases insulin secretion and increases insulin clearance in humans. Hypertens (Dallas Tax 1979) 75:1251–1259. https://doi.org/10.1161/HYPERTENSIONAHA.119.13922

Article  CAS  Google Scholar 

Classification and Diagnosis of Diabetes (2022) Standards of medical care in diabetes-2022. Diabetes Care 45:S17-38. https://doi.org/10.2337/DC22-S002

Article  Google Scholar 

Chen W, Li F, He C, Zhu Y, Tan W (2014) Elevated prevalence of abnormal glucose metabolism in patients with primary aldosteronism: a meta-analysis. Ir J Med Sci 183:283–291. https://doi.org/10.1007/S11845-013-1007-X

Article  CAS  PubMed  Google Scholar 

Muscelli EO, Saad MJ, Gontijo JA (1990) Insulin resistance in essential hypertension. Braz J Med Biol Res 23:1253–1257. https://doi.org/10.1056/nejm198708063170605

Article  CAS  PubMed  Google Scholar 

Fallo F, Veglio F, Bertello C, Sonino N, Della Mea P, Ermani M et al (2006) Prevalence and characteristics of the metabolic syndrome in primary aldosteronism. J Clin Endocrinol Metab 91:454–459. https://doi.org/10.1210/jc.2005-1733

Article  CAS  PubMed  Google Scholar 

Zhang C, Jiang Y, Su T, Jiang L, Zhou W, Zhong X et al (2022) Newly diagnosed diabetes mellitus is a risk factor for cardiocerebrovascular events in primary aldosteronism. Endocrine 77:519–526. https://doi.org/10.1007/S12020-022-03095-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin YF, Peng KY, Chang CH, Hu YH, Wu VC, Chung SD (2020) Changes in glucose metabolism after adrenalectomy or treatment with a mineralocorticoid receptor antagonist for primary aldosteronism. Endocrinol Metab (Seoul, Korea) 35:838–846. https://doi.org/10.3803/ENM.2020.797

Article  CAS  Google Scholar 

Gerards J, Heinrich DA, Adolf C, Meisinger C, Rathmann W, Sturm L et al (2019) Impaired glucose metabolism in primary aldosteronism is associated with cortisol cosecretion. J Clin Endocrinol Metab 104:3192–3202. https://doi.org/10.1210/jc.2019-00299

Article  PubMed  Google Scholar 

Araujo-Castro M, Paja Fano M, González Boillos M, Pla Peris B, Pascual-Corrales E, García Cano AM et al (2022) Evolution of the cardiometabolic profile of primary hyperaldosteronism patients treated with adrenalectomy and with mineralocorticoid receptor antagonists: results from the SPAIN-ALDO Registry. Endocrine 76:687–696. https://doi.org/10.1007/s12020-022-03029-4

Article  CAS  PubMed  Google Scholar 

Harris PA, Taylor R, Minor BL, Elliott V, Fernandez M, O’Neal L et al (2019) The REDCap consortium: building an international community of software platform partners. J Biomed Inform 95:103208. https://doi.org/10.1016/j.jbi.2019.103208

Article  PubMed  PubMed Central  Google Scholar 

harris Pa, taylor r, thielke r, payne j, gonzalez n, conde jg (2009) research electronic data capture (redcap)-a metadata-driven methodology and workflow process for providing translational research informatics support. j biomed inform 42:377–381. https://doi.org/10.1016/j.jbi.2008.08.010

Article  PubMed  Google Scholar 

araujo-castro M, paja fano m, gonzález boillos m, pla peris b, pascual-corrales e, garcía cano am et al (2022) predictive model of hypertension resolution after adrenalectomy in primary aldosteronism: the spain-aldo score. j hypertens 40:2486–2493. https://doi.org/10.1097/hjh.0000000000003284

Article  CAS  PubMed  Google Scholar 

monticone S, sconfienza e, d’ascenzo f, buffolo f, satoh f, sechi la et al (2020) renal damage in primary aldosteronism: a systematic review and meta-analysis. J Hypertens. https://doi.org/10.1097/HJH.0000000000002216

Article  PubMed  Google Scholar 

ElSayed NA, Aleppo G, Aroda VR, Bannuru RR, Brown FM, Bruemmer D et al (2023) 2. Classification and diagnosis of diabetes: standards of care in diabetes-2023. Diabetes Care 46:S19–S40. https://doi.org/10.2337/DC23-S002

Article  CAS  PubMed  Google Scholar 

National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) (2002) Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report. Circulation 106:3143–3421. https://doi.org/10.1161/circ.106.25.3143.

Article  Google Scholar 

Araujo-Castro M, Sampedro Núñez MA, Marazuela M (2019) Autonomous cortisol secretion in adrenal incidentalomas. Endocrine 64:1–13. https://doi.org/10.1007/s12020-019-01888-y

Article  CAS  PubMed  Google Scholar 

Williams TA, Lenders JWM, Mulatero P, Burrello J, Rottenkolber M, Adolf C et al (2017) Outcomes after adrenalectomy for unilateral primary aldosteronism: an international consensus on outcome measures and analysis of remission rates in an international cohort. Lancet Diabetes Endocrinol 5:689–699. https://doi.org/10.1016/S2213-8587(17)30135-3

Article  PubMed  PubMed Central  Google Scholar 

Hanslik G, Wallaschofski H, Dietz A, Riester A, Reincke M, Allolio B et al (2015) Increased prevalence of diabetes mellitus and the metabolic syndrome in patients with primary aldosteronism of the German Conn’s Registry. Eur J Endocrinol 173:665–675. https://doi.org/10.1530/EJE-15-0450

Article  CAS  PubMed  Google Scholar 

Kwak MK, Lee JY, Kim BJ, Lee SH, Koh JM (2019) Effects of primary aldosteronism and different therapeutic modalities on glucose metabolism. J Clin Med 8:2194. https://doi.org/10.3390/jcm8122194

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cole JB, Florez JC (2020) Genetics of diabetes mellitus and diabetes complications. Nat Rev Nephrol 16:377–390. https://doi.org/10.1038/S41581-020-0278-5

Article  PubMed  PubMed Central  Google Scholar 

Ohno Y, Sone M, Inagaki N, Yamasaki T, Ogawa O, Takeda Y et al (2018) Obesity as a key factor underlying idiopathic hyperaldosteronism. J Clin Endocrinol Metab 103:4456–4464. https://doi.org/10.1210/jc.2018-00866

Article  PubMed  Google Scholar 

Rossi GP, Belfiore A, Bernini G, Fabris B, Caridi G, Ferri C et al (2008) Body mass index predicts plasma aldosterone concentrations in overweight-obese primary hypertensive patients. J Clin Endocrinol Metab 93:2566–2571. https://doi.org/10.1210/JC.2008-0251

Article  CAS  PubMed  Google Scholar 

Spyroglou A, Handgriff L, Müller L, Schwarzlmüller P, Parasiliti-Caprino M, Fuss CT et al (2022) The metabolic phenotype of patients with primary aldosteronism: impact of subtype and sex - a multicenter-study of 3566 Caucasian and Asian subjects. Eur J Endocrinol 187:361–372. https://doi.org/10.1530/EJE-22-0040

Article  CAS  PubMed  Google Scholar 

Okazaki-Hada M, Moriya A, Nagao M, Oikawa S, Fukuda I, Sugihara H (2020) Different pathogenesis of glucose intolerance in two subtypes of primary aldosteronism: aldosterone-producing adenoma and idiopathic hyperaldosteronism. J Diabetes Investig 11:1511–1519. https://doi.org/10.1111/JDI.13312

Article  CAS  PubMed  PubMed Central  Google Scholar 

Franch Nadal J, Mata Cases M, Mauricio PD (2016) Epidemiology and clinical management of type 2 diabetes mellitus and associated comorbidities in Spain (e-Management study). Med Clin (Barc) 147(Suppl 1):1–7. https://doi.org/10.1016/S0025-7753(17)30618-8

Article  PubMed  Google Scholar 

Monticone S, D’Ascenzo F, Moretti C, Williams TA, Veglio F, Gaita F et al (2018) Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and meta-analysis. Lancet Diabetes Endocrinol 6:41–50. https://doi.org/10.1016/S2213-8587(17)30319-4

Article  CAS  PubMed  Google Scholar 

Rojo-Martínez G, Valdés S, Soriguer F, Vendrell J, Urrutia I, Pérez V et al (2020) Incidence of diabetes mellitus in Spain as results of the nation-wide cohort di@bet.es study. Sci Rep. https://doi.org/10.1038/s41598-020-59643-7

Article  PubMed  PubMed Central  Google Scholar 

Kreze A, Kreze-Spirova E, Mikulecky M (2000) Diabetes mellitus in primary aldosteronism. Bratisl Lek Listy 101:187–190

PubMed  Google Scholar 

Giacchetti G, Ronconi V, Turchi F, Agostinelli L, Mantero F, Rilli S et al (2007) Aldosterone as a key mediator of the cardiometabolic syndrome in primary aldosteronism: an observational study. J Hypertens 25:177–186. https://doi.org/10.1097/HJH.0b013e3280108e6f

Article  CAS  PubMed  Google Scholar 

Moustaki M, Paschou SA, Vakali EC, Vryonidou A (2022) Secondary diabetes mellitus due to primary aldosteronism. Endocrine. https://doi.org/10.1007/s12020-022-03168-8

Article  PubMed  Google Scholar 

Nazarzadeh M, Bidel Z, Canoy D, Copland E, Wamil M, Majert J et al (2021) Blood pressure lowering and risk of new-onset type 2 diabetes: an individual participant data meta-analysis. Lancet (London, England) 398:1803–1810. https://doi.org/10.1016/S0140-6736(21)01920-6

Article  CAS  PubMed  Google Scholar 

Wu VC, Chan CK, Wu WC, Peng KY, Chang YS, Yeh FY et al (2022) New-onset diabetes mellitus risk associated with concurrent autonomous cortisol secretion in patients with primary aldosteronism. Hypertens Res. https://doi.org/10.1038/S41440-022-01086-W

Article  PubMed  Google Scholar