The Reported Adverse Events of Metformin: A Descriptive Analysis Using Data from VigiBase

Aim: Metformin is a well-established component of diabetes management. It is generally safe and well-tolerated
but may cause several adverse events. The present study aimed to describe the reported adverse events of
metformin. Methods: This was a descriptive analysis that was conducted using data from VigiBase to describe
the reported adverse events of metformin use. Results: Till October 23, 2022, 100,993 metformin adverse event
reports were submitted to the world health organization’s global database (VigiBase). More than 57% of the
patients were female and 42.49% of them were male. Conclusions: Gastrointestinal problems, abnormalities of
metabolism and nutrition, general disorders, and conditions at the administration site were the most frequently
reported side effects of metformin use. To reduce metformin adverse medication events, appropriate interventions
such as targeted education should be implemented. Pharmacists should monitor their patients continuously to
ensure the safe use of the medication.

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