Aleksic T, Gray N, Wu X et al (2018) Nuclear IGF1R interacts with regulatory regions of chromatin to promote RNA polymerase II recruitment and gene expression associated with advanced tumor stage. Cancer Res 78:3497–3509. https://doi.org/10.1158/0008-5472.CAN-17-3498

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bannister AJ, Kouzarides T (2011) Regulation of chromatin by histone modifications. Cell Res 21:381–395. https://doi.org/10.1038/cr.2011.22

Article  CAS  PubMed  PubMed Central  Google Scholar 

Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Stat Soc: Ser B (methodol) 57:289–300. https://doi.org/10.1111/j.2517-6161.1995.tb02031.x

Article  Google Scholar 

Brand TM, Iida M, Li C, Wheeler DL (2011) The nuclear epidermal growth factor receptor signaling network and its role in cancer. Discov Med 12:419–432

PubMed  PubMed Central  Google Scholar 

Bryant DM, Stow JL (2005) Nuclear translocation of cell-surface receptors: lessons from fibroblast growth factor. Traffic 6:947–954. https://doi.org/10.1111/j.1600-0854.2005.00332.x

Article  CAS  PubMed  Google Scholar 

Carpenter G, Liao H-J (2013) Receptor tyrosine kinases in the nucleus. Cold Spring Harb Perspect Biol 5:a008979–a008979. https://doi.org/10.1101/cshperspect.a008979

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carter-Su C, Schwartz J, Argetsinger LS (2016) Growth hormone signaling pathways. Growth Hormon IGF Res 28:11–15. https://doi.org/10.1016/j.ghir.2015.09.002

Article  CAS  Google Scholar 

Chhabra Y, Waters MJ, Brooks AJ (2011) Role of the growth hormone–IGF-1 axis in cancer. Expert Rev Endocrinol Metab 6:71–84. https://doi.org/10.1586/eem.10.73

Article  CAS  PubMed  Google Scholar 

Chhabra Y, Lee CMM, Müller AF, Brooks AJ (2021) GHR signalling: Receptor activation and degradation mechanisms. Mol Cell Endocrinol 520:111075. https://doi.org/10.1016/j.mce.2020.111075

Article  CAS  PubMed  Google Scholar 

Choi M, Chang C-Y, Clough T et al (2014) MSstats: an R package for statistical analysis of quantitative mass spectrometry-based proteomic experiments. Bioinformatics 30:2524–2526. https://doi.org/10.1093/bioinformatics/btu305

Article  CAS  PubMed  Google Scholar 

Conway-Campbell BL, Wooh JW, Brooks AJ et al (2007) Nuclear targeting of the growth hormone receptor results in dysregulation of cell proliferation and tumorigenesis. Proc Natl Acad Sci USA 104:13331–13336. https://doi.org/10.1073/pnas.0600181104

Article  CAS  PubMed  PubMed Central  Google Scholar 

Conway-Campbell BL, Brooks AJ, Robinson PJ et al (2008) The extracellular domain of the growth hormone receptor interacts with coactivator activator to promote cell proliferation. Mol Endocrinol 22:2190–2202. https://doi.org/10.1210/me.2008-0128

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dehkhoda F, Lee CMM, Medina J, Brooks AJ (2018) The growth hormone receptor: mechanism of receptor activation, cell signaling, and physiological aspects. Front Endocrinol (lausanne) 9:35. https://doi.org/10.3389/fendo.2018.00035

Article  PubMed  Google Scholar 

Figueiredo MA, Boyle RT, Sandrini JZ et al (2016) High level of GHR nuclear translocation in skeletal muscle of a hyperplasic transgenic zebrafish. J Mol Endocrinol 56:47–54. https://doi.org/10.1530/JME-15-0185

Article  CAS  PubMed  Google Scholar 

Fiorillo AA, Medler TR, Feeney YB et al (2011) HMGN2 inducibly binds a novel transactivation domain in nuclear PRLr to coordinate Stat5a-mediated transcription. Mol Endocrinol 25:1550–1564. https://doi.org/10.1210/me.2011-0106

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fuller-Pace FV (2006) DExD/H box RNA helicases: multifunctional proteins with important roles in transcriptional regulation. Nucleic Acids Res 34:4206–4215. https://doi.org/10.1093/nar/gkl460

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goffin V, Shiverick KT, Kelly PA, Martial JA (1996) Sequence-function relationships within the expanding family of prolactin, growth hormone, placental lactogen, and related proteins in mammals. Endocr Rev 17:385–410. https://doi.org/10.1210/er.17.4.385

Article  CAS  PubMed  Google Scholar 

Gómez-Rubio V (2017) ggplot2: Elegant graphics for data analysis (2nd Edition). J Stat Softw 77:3–5. https://doi.org/10.18637/jss.v077.b02

Graichen R, Sandstedt J, Goh ELK et al (2003) The growth hormone-binding protein is a location-dependent cytokine receptor transcriptional enhancer. J Biol Chem 278:6346–6354. https://doi.org/10.1074/jbc.M207546200

Article  CAS  PubMed  Google Scholar 

Greenhalgh CJ, Bertolino P, Asa SL et al (2002) Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b). Mol Endocrinol 16:1394–1406. https://doi.org/10.1210/mend.16.6.0845

Article  CAS  PubMed  Google Scholar 

Hainan L, Huilin L, Khan M et al (2018) The basic route of the nuclear translocation porcine growth hormone (GH)-growth hormone receptor (GHR) complex (pGH/GHR) in porcine hepatocytes. Gen Comp Endocrinol 266:101–109. https://doi.org/10.1016/j.ygcen.2018.05.002

Article  CAS  PubMed  Google Scholar 

Hung L-Y, Tseng JT, Lee Y-C et al (2008) Nuclear epidermal growth factor receptor (EGFR) interacts with signal transducer and activator of transcription 5 (STAT5) in activating Aurora-A gene expression. Nucleic Acids Res 36:4337–4351. https://doi.org/10.1093/nar/gkn417

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kai M (2016) Roles of RNA-binding proteins in DNA damage response. Int J Mol Sci 17:310. https://doi.org/10.3390/ijms17030310

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kehl T, Schneider L, Schmidt F et al (2017) RegulatorTrail: a web service for the identification of key transcriptional regulators. Nucleic Acids Res 45:W146–W153. https://doi.org/10.1093/nar/gkx350

Article  CAS  PubMed  PubMed Central  Google Scholar 

Klaus B, Reisenauer S (2016) An end to end workflow for differential gene expression using Affymetrix microarrays. F1000Res 5:1384. https://doi.org/10.12688/f1000research.8967.2

Kostopoulou E, Rojas-Gil AP, Karvela A, Spiliotis BE (2017) Epidermal growth factor receptor (EGFR) involvement in successful growth hormone (GH) signaling in GH transduction defect. J Pediatr Endocrinol Metab 30:221–230. https://doi.org/10.1515/jpem-2016-0189

Article  CAS  PubMed  Google Scholar 

Kugler JE, Horsch M, Huang D et al (2013) High mobility group N proteins modulate the fidelity of the cellular transcriptional profile in a tissue- and variant-specific manner. J Biol Chem 288:16690–16703. https://doi.org/10.1074/jbc.M113.463315

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lan HN, Hong P, Li RN et al (2017) Growth hormone-specific induction of the nuclear localization of porcine growth hormone receptor in porcine hepatocytes. Domest Anim Endocrinol 61:39–47. https://doi.org/10.1016/j.domaniend.2017.05.003

Article  CAS  PubMed  Google Scholar 

Lan H, Liu H, Hong P et al (2018) Porcine growth hormone induces the nuclear localization of porcine growth hormone receptor in vivo. Asian-Australas J Anim Sci 31:499–504. https://doi.org/10.5713/ajas.17.0585

Article  CAS  PubMed  Google Scholar 

Li X, Huang Y, Jiang J, Frank SJ (2008) ERK-dependent threonine phosphorylation of EGF receptor modulates receptor downregulation and signaling. Cell Signal 20:2145–2155. https://doi.org/10.1016/j.cellsig.2008.08.006

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li X, Huang Y, Jiang J, Frank SJ (2011) Synergy in ERK activation by cytokine receptors and tyrosine kinase growth factor receptors. Cell Signal 23:417–424. https://doi.org/10.1016/j.cellsig.2010.10.016

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lim J-H, Catez F, Birger Y et al (2004) Chromosomal protein HMGN1 modulates histone H3 phosphorylation. Mol Cell 15:573–584. https://doi.org/10.1016/j.molcel.2004.08.006

Article  CAS  PubMed  Google Scholar 

Lim J-H, West KL, Rubinstein Y et al (2005) Chromosomal protein HMGN1 enhances the acetylation of lysine 14 in histone H3. EMBO J 24:3038–3048. https://doi.org/10.1038/sj.emboj.7600768

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin SY, Makino K, Xia W et al (2001) Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nat Cell Biol 3:802–808. https://doi.org/10.1038/ncb0901-802

Article  CAS  PubMed  Google Scholar 

Lincoln DT, Sinowatz F, Temmim-Baker L et al (1998) Growth hormone receptor expression in the nucleus and cytoplasm of normal and neoplastic cells. Histochem Cell Biol 109:141–159. https://doi.org/10.1007/s004180050212

Article  CAS  PubMed  Google Scholar 

Lo H-W, Hsu S-C, Ali-Seyed M et al (2005) Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway. Cancer Cell 7:575–589. https://doi.org/10.1016/j.ccr.2005.05.007

Article  CAS  PubMed