Solano JP, Gomes B, Higginson IJ. A comparison of symptom prevalence in far advanced cancer, AIDS, heart disease, chronic obstructive pulmonary disease and renal disease. J Pain Symptom Manage. 2006;31:58–69.

Article  PubMed  Google Scholar 

Hui D, dos Santos R, Chisholm GB, Bruera E. Symptom expression in the last seven days of life among cancer patients admitted to acute palliative care units. J Pain Symptom Manage. 2015;50:488–94.

Article  PubMed  Google Scholar 

Imai K, Morita T, Yokomichi N, et al. Efficacy of proportional sedation and deep sedation defined by sedation protocols: a multicenter, prospective, observational comparative study. J Pain Symptom Manage. 2021;62:1165–74.

Yokomichi N, Yamaguchi T, Maeda I, et al. Effect of continuous deep sedation on survival in the last days of life of cancer patients: a multicenter prospective cohort study. Palliat Med. 2022;36:189–99.

Article  PubMed  Google Scholar 

Smith EL, Hann DM, Ahles TA, et al. Dyspnea, anxiety, body consciousness, and quality of life in patients with lung cancer. J Pain Symptom Manage. 2001;21:323–9.

Article  CAS  PubMed  Google Scholar 

Reddy SK, Parsons HA, Elsayem A, Palmer JL, Bruera E. Characteristics and correlates of dyspnea in patients with advanced cancer. J Palliat Med. 2009;12:29–36.

Article  PubMed  Google Scholar 

Cuervo Pinna MA, Mota Vargas R, Redondo Moralo MJ, Sanchez Correas MA, Pera BG. Dyspnea–a bad prognosis symptom at the end of life. Am J Hosp Palliat Care. 2009;26:89–97.

Article  PubMed  Google Scholar 

Parshall MB, Schwartzstein RM, Adams L, et al. An official American Thoracic Society statement: update on the mechanisms, assessment, and management of dyspnea. Am J Respir Crit Care Med. 2012;185:435–52.

Article  PubMed  PubMed Central  Google Scholar 

Lovell N, Etkind SN, Bajwah S, Maddocks M, Higginson IJ. Control and context are central for people with advanced illness experiencing breathlessness: a systematic review and thematic synthesis. J Pain Symptom Manage. 2019;57(140–55): e2.

Google Scholar 

Johnson MJ, Yorke J, Hansen-Flaschen J, et al. Towards an expert consensus to delineate a clinical syndrome of chronic breathlessness. Eur Respir J. 2017;49:1602277.

Simon ST, Weingartner V, Higginson IJ, Voltz R, Bausewein C. Definition, categorization, and terminology of episodic breathlessness: consensus by an international Delphi survey. J Pain Symptom Manage. 2014;47:828–38.

Article  PubMed  Google Scholar 

Mori M, Yamaguchi T, Matsuda Y, et al. Unanswered questions and future direction in the management of terminal breathlessness in patients with cancer. ESMO open. 2020;5: e000603.

Article  PubMed  PubMed Central  Google Scholar 

Fukushi I, Pokorski M, Okada Y. Mechanisms underlying the sensation of dyspnea. Respir Investig. 2021;59:66–80.

Article  CAS  PubMed  Google Scholar 

McKenzie E, Hwang MK, Chan S, et al. Predictors of dyspnea in patients with advanced cancer. Ann Palliat Med. 2018;7:427–36.

Article  PubMed  Google Scholar 

Matsunuma R, Yamaguchi T, Mori M, et al. Predictive factors for the development of dyspnea within 7 days after admission among terminally ill cancer patients. Am J Hosp Palliat Care. 2022;39:413–20.

Article  PubMed  Google Scholar 

Hui D, Bohlke K, Bao T, et al. Management of dyspnea in advanced cancer: ASCO guideline. J Clin Oncol. 2021;39:1389–411.

Hui D, Maddocks M, Johnson MJ, et al. Management of breathlessness in patients with cancer: ESMO clinical practice guidelines. ESMO Open. 2020;5:e001038.

Wedzicha JA, Miravitlles M, Hurst JR, et al. Management of COPD exacerbations: a European Respiratory Society/American Thoracic Society guideline. Eur Respir J. 2017;49:1600791.

Suzuki A, Kondoh Y, Brown KK, et al. Acute exacerbations of fibrotic interstitial lung diseases. Respirology. 2020;25:525–34.

Article  PubMed  Google Scholar 

Long K, Suresh K. Pulmonary toxicity of systemic lung cancer therapy. Respirology. 2020;25(Suppl 2):72–9.

Article  PubMed  Google Scholar 

Nahm SH, Heywood R, Callaghan S, et al. Patient and treatment characteristics of emergency presentations due to immune-mediated toxicities. Eur J Cancer. 2022;164:62–9.

Article  CAS  PubMed  Google Scholar 

Curigliano G, Lenihan D, Fradley M, et al. Management of cardiac disease in cancer patients throughout oncological treatment: ESMO consensus recommendations. Ann Oncol. 2020;31:171–90.

Article  CAS  PubMed  Google Scholar 

Muruganandan S, Azzopardi M, Thomas R, et al. The Pleural Effusion And Symptom Evaluation (PLEASE) study of breathlessness in patients with a symptomatic pleural effusion. Eur Respir J. 2020;55:1900980.

Dipper A, Bhatnagar R, Maskell N. Outpatient talc administration via indwelling pleural catheters for malignant effusions. Curr Opin Pulm Med. 2019;25:380–3.

Article  PubMed  Google Scholar 

Smith TA, Cho JG, Roberts MM, Swami V, Wheatley JR. Hand-held fans: physical properties and perceptions of patients with COPD. J Pain Symptom Manage. 2022;63:e9–16.

Article  PubMed  Google Scholar 

Gupta A, Sedhom R, Sharma R, et al. Nonpharmacological interventions for managing breathlessness in patients with advanced cancer: a systematic review. JAMA Oncol. 2021;7:290–8.

Article  PubMed  Google Scholar 

Kako J, Morita T, Yamaguchi T, et al. Fan therapy is effective in relieving dyspnea in patients with terminally ill cancer: a parallel-arm, randomized controlled trial. J Pain Symptom Manage. 2018;56:493–500.

Article  PubMed  Google Scholar 

Yamamoto S, Arao H, Aoki M, et al. Care associated with satisfaction of bereaved family members of terminally ill cancer patients with dyspnea: a cross-sectional nationwide survey. J Pain Symptom Manage. 2021;62:796–804.

Article  PubMed  Google Scholar 

Yates P, Hardy J, Clavarino A, et al. A randomized controlled trial of a non-pharmacological intervention for cancer-related dyspnea. Front Oncol. 2020;10: 591610.

Article  PubMed  PubMed Central  Google Scholar 

Higginson IJ, Bausewein C, Reilly CC, et al. An integrated palliative and respiratory care service for patients with advanced disease and refractory breathlessness: a randomised controlled trial. Lancet Respir Med. 2014;2:979–87.

Article  PubMed  Google Scholar 

McDonnell KK, Gallerani DG, Newsome BR, et al. A prospective pilot study evaluating feasibility and preliminary effects of breathe easier: a mindfulness-based intervention for survivors of lung cancer and their family members (Dyads). Integr Cancer Ther. 2020;19:1534735420969829.

Article  PubMed  PubMed Central  Google Scholar 

Fernandez Rodriguez EJ, Rihuete Galve MI, Cruz Hernandez JJ. Impact of a comprehensive functional rehabilitation programme on the quality of life of the oncological patient with dyspnoea. Med Clin (Barc). 2021;157:10–6.

PubMed  Google Scholar 

Dogan N, Tasci S. The effects of acupressure on quality of life and dyspnea in lung cancer: a randomized, controlled trial. Altern Ther Health Med. 2020;26:49–56.

PubMed  Google Scholar 

Wyatt G, Sikorskii A, Rahbar MH, Victorson D, You M. Health-related quality-of-life outcomes: a reflexology trial with patients with advanced-stage breast cancer. Oncol Nurs Forum. 2012;39:568–77.

Article  PubMed  PubMed Central  Google Scholar 

Jacobs SS, Krishnan JA, Lederer DJ, et al. Home oxygen therapy for adults with chronic lung disease. An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med. 2020;202:121–41.

Article  Google Scholar 

Uronis HE, Currow DC, McCrory DC, Samsa GP, Abernethy AP. Oxygen for relief of dyspnoea in mildly- or non-hypoxaemic patients with cancer: a systematic review and meta-analysis. Br J Cancer. 2008;98:294–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ekstrom M, Ahmadi Z, Bornefalk-Hermansson A, Abernethy A, Currow D. Oxygen for breathlessness in patients with chronic obstructive pulmonary disease who do not qualify for home oxygen therapy. Cochrane Database Syst Rev. 2016;11:CD006429.

PubMed  Google Scholar 

Watanabe H, Satou F, Taniguchi A, Yamamoto C, Odagiri T, Asai Y. Adverse effects of oxygen therapy for dyspnea in terminally ill cancer patients: a retrospective single center analysis. Palliat Care Res. 2019;14:245–51.

Article  Google Scholar 

Nava S, Ferrer M, Esquinas A, et al. Palliative use of non-invasive ventilation in end-of-life patients with solid tumours: a randomised feasibility trial. Lancet Oncol. 2013;14:219–27.

Article  PubMed  Google Scholar 

Hui D, Morgado M, Chisholm G, et al. High-flow oxygen and bilevel positive airway pressure for persistent dyspnea in patients with advanced cancer: a phase II randomized trial. J Pain Symptom Manage. 2013;46:463–73.

Article  PubMed  PubMed Central  Google Scholar 

Ruangsomboon O, Dorongthom T, Chakorn T, et al. High-flow nasal cannula versus conventional oxygen therapy in relieving dyspnea in emergency palliative patients with do-not-intubate status: a randomized crossover study. Ann Emerg Med. 2020;75:615–26.

Article  PubMed  Google Scholar 

Xu Z, Li P, Zhang C, Ma D. Effect of heated humidified high-flow nasal cannula (HFNC) oxygen therapy in dyspnea patients with advanced cancer, a randomized controlled clinical trial. Support Care Cancer. 2022;30:9093–100.

Article  PubMed  Google Scholar 

Hui D, Hernandez F, Urbauer D, et al. High-flow oxygen and high-flow air for dyspnea in Hospitalized patients with cancer: a pilot crossover randomized clinical trial. Oncologist. 2021;26:e883–92.

Article  CAS  PubMed  Google Scholar 

Chow R, Hui D, Caini S, et al. Prophylaxis and treatment of cancer-related dyspnea with pharmacologic agents: a systematic review and network meta-analysis. Palliat Support Care. 2022;20:744–51.

PubMed  Google Scholar 

Feliciano JL, Waldfogel JM, Sharma R, et al. Pharmacologic interventions for breathlessness in patients with advanced cancer: a systematic review and meta-analysis. JAMA Netw Open. 2021;4: e2037632.

Article  PubMed  PubMed Central