Distinct maternal metabolites are associated with obesity and glucose-insulin axis in the first trimester of pregnancy

Metzger BE, Coustan DR, Trimble ER. Hyperglycemia and adverse pregnancy outcomes. Clin Chem. 2019;65:937–8.

Article  CAS  PubMed  Google Scholar 

Catalano PM, Shankar K. Obesity and pregnancy: mechanisms of short term and long term adverse consequences for mother and child. BMJ. 2017;356:j1.

Article  PubMed  PubMed Central  Google Scholar 

Poston L, Caleyachetty R, Cnattingius S, Corvalan C, Uauy R, Herring S, et al. Preconceptional and maternal obesity: epidemiology and health consequences. Lancet Diabetes Endocrinol. 2016;4:1025–36.

Article  PubMed  Google Scholar 

Cnattingius S, Bergstrom R, Lipworth L, Kramer MS. Prepregnancy weight and the risk of adverse pregnancy outcomes. N Engl J Med. 1998;338:147–52.

Article  CAS  PubMed  Google Scholar 

Entringer S, Buss C, Swanson JM, Cooper DM, Wing DA, Waffarn F, et al. Fetal programming of body composition, obesity, and metabolic function: the role of intrauterine stress and stress biology. J Nutr Metab. 2012;2012:632548.

Article  PubMed  PubMed Central  Google Scholar 

Mamun AA, O’Callaghan MJ, Williams GM, Najman JM. Change in maternal body mass index is associated with offspring body mass index: a 21-year prospective study. Eur J Nutr. 2013;52:1597–606.

Article  PubMed  Google Scholar 

Heslehurst N, Vieira R, Akhter Z, Bailey H, Slack E, Ngongalah L, et al. The association between maternal body mass index and child obesity: a systematic review and meta-analysis. PLoS Med. 2019;16:e1002817.

Article  PubMed  PubMed Central  Google Scholar 

Liu Y, Kuang A, Bain JR, Muehlbauer MJ, Ilkayeva OR, Lowe LP, et al. Maternal metabolites associated with gestational diabetes mellitus and a postpartum disorder of glucose metabolism. J Clin Endocrinol Metab. 2021;106:3283–94.

Article  PubMed  PubMed Central  Google Scholar 

Liu Y, Kuang A, Talbot O, Bain JR, Muehlbauer MJ, Hayes MG, et al. Metabolomic and genetic associations with insulin resistance in pregnancy. Diabetologia. 2020;63:1783–95.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kadakia R, Nodzenski M, Talbot O, Kuang A, Bain JR, Muehlbauer MJ, et al. Maternal metabolites during pregnancy are associated with newborn outcomes and hyperinsulinaemia across ancestries. Diabetologia. 2019;62:473–84.

Article  CAS  PubMed  Google Scholar 

Sandler V, Reisetter AC, Bain JR, Muehlbauer MJ, Nodzenski M, Stevens RD, et al. Associations of maternal BMI and insulin resistance with the maternal metabolome and newborn outcomes. Diabetologia. 2017;60:518–30.

Article  CAS  PubMed  Google Scholar 

Scholtens DM, Bain JR, Reisetter AC, Muehlbauer MJ, Nodzenski M, Stevens RD, et al. Metabolic networks and metabolites underlie associations between maternal glucose during pregnancy and newborn size at birth. Diabetes. 2016;65:2039–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Q, Wurtz P, Auro K, Makinen VP, Kangas AJ, Soininen P, et al. Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence. BMC Med. 2016;14:205.

Article  PubMed  PubMed Central  Google Scholar 

Huynh J, Xiong G, Bentley-Lewis R. A systematic review of metabolite profiling in gestational diabetes mellitus. Diabetologia. 2014;57:2453–64.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jacob S, Nodzenski M, Reisetter AC, Bain JR, Muehlbauer MJ, Stevens RD, et al. Targeted metabolomics demonstrates distinct and overlapping maternal metabolites associated with BMI, glucose, and insulin sensitivity during pregnancy across four ancestry groups. Diabetes Care. 2017;40:911–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hellmuth C, Lindsay KL, Uhl O, Buss C, Wadhwa PD, Koletzko B, et al. Association of maternal prepregnancy BMI with metabolomic profile across gestation. Int J Obes. 2017;41:159–69.

Article  CAS  Google Scholar 

Riskin-Mashiah S, Younes G, Damti A, Auslender R. First-trimester fasting hyperglycemia and adverse pregnancy outcomes. Diabetes Care. 2009;32:1639–43.

Article  PubMed  PubMed Central  Google Scholar 

Bandres-Meriz J, Dieberger AM, Hoch D, Pochlauer C, Bachbauer M, Glasner A, et al. Maternal obesity affects the glucose-insulin axis during the first trimester of human pregnancy. Front Endocrinol. 2020;11:566673.

Article  Google Scholar 

Bandres-Meriz J, Majali-Martinez A, Hoch D, Morante M, Glasner A, van Poppel MNM, et al. Maternal C-peptide and insulin sensitivity, but not BMI, associate with fatty acids in the first trimester of pregnancy. Int J Mol Sci. 2021;22:19.

Article  Google Scholar 

Blüher M. Metabolically healthy obesity. Endocr Rev. 2020;41:bnaa004.

Article  PubMed  PubMed Central  Google Scholar 

Radaelli T, Farrell KA, Huston-Presley L, Amini SB, Kirwan JP, McIntyre HD, et al. Estimates of insulin sensitivity using glucose and C-Peptide from the hyperglycemia and adverse pregnancy outcome glucose tolerance test. Diabetes Care. 2010;33:490–4.

Article  CAS  PubMed  Google Scholar 

Team RC. R: A language and environment for statistical computing. In: Computing RFfS, (ed). https://www.R-project.org Vienna, Austria, 2018.

Pang Z, Chong J, Zhou G, de Lima Morais DA, Chang L, Barrette M, et al. MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights. Nucleic Acids Res. 2021;49:W388–96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc B. 1995;57:289–300.

Google Scholar 

Do KT, Rasp DJN, Kastenmuller G, Suhre K, Krumsiek J. MoDentify: phenotype-driven module identification in metabolomics networks at different resolutions. Bioinformatics. 2019;35:532–4.

Article  CAS  PubMed  Google Scholar 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13:2498–504.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xia J, Wishart DS. MSEA: a web-based tool to identify biologically meaningful patterns in quantitative metabolomic data. Nucleic Acids Res. 2010;38:W71–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xia J, Wishart DS. MetPA: a web-based metabolomics tool for pathway analysis and visualization. Bioinformatics. 2010;26:2342–4.

Article  CAS  PubMed  Google Scholar 

Kanehisa M, Araki M, Goto S, Hattori M, Hirakawa M, Itoh M, et al. KEGG for linking genomes to life and the environment. Nucleic Acids Res. 2008;36:D480–4.

Article  CAS  PubMed  Google Scholar 

Kim S, Chen J, Cheng T, Gindulyte A, He J, He S, et al. PubChem 2019 update: improved access to chemical data. Nucleic Acids Res. 2019;47:D1102–9.

Article  PubMed  Google Scholar 

de Matos P, Alcantara R, Dekker A, Ennis M, Hastings J, Haug K, et al. Chemical entities of biological interest: an update. Nucleic Acids Res. 2010;38:D249–54.

Article  PubMed  Google Scholar 

Lain KY, Catalano PM. Metabolic changes in pregnancy. Clin Obstet Gynecol. 2007;50:938–48.

Article  PubMed  Google Scholar 

Napso T, Yong HEJ, Lopez-Tello J, Sferruzzi-Perri AN. The role of placental hormones in mediating maternal adaptations to support pregnancy and lactation. Front Physiol. 2018;9:1091.

Article  PubMed  PubMed Central  Google Scholar 

Tinius RA, Blankenship MM, Furgal KE, Cade WT, Pearson KJ, Rowland NS, et al. Metabolic flexibility is impaired in women who are pregnant and overweight/obese and related to insulin resistance and inflammation. Metabolism. 2020;104:154142.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Handelman SK, Romero R, Tarca AL, Pacora P, Ingram B, Maymon E, et al. The plasma metabolome of women in early pregnancy differs from that of non-pregnant women. PLoS ONE. 2019;14:e0224682.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lindsay KL, Hellmuth C, Uhl O, Buss C, Wadhwa PD, Koletzko B, et al. Longitudinal metabolomic profiling of amino acids and lipids across healthy pregnancy. PLoS ONE. 2015;10:e0145794.

Article  PubMed  PubMed Central  Google Scholar 

Felig P, Marliss E, Cahill GF Jr. Plasma amino acid levels and insulin secretion in obesity. N Engl J Med. 1969;281:811–6.

Article  CAS  PubMed  Google Scholar 

Moore SC, Matthews CE, Sampson JN, Stolzenberg-Solomon RZ, Zheng W, Cai Q, et al. Human metabolic correlates of body mass index. Metabolomics. 2014;10:259–69.

Article  CAS  PubMed

留言 (0)

沒有登入
gif