Andreini C, Putignano V, Rosato A, Banci L. The human iron-proteome. Metallomics. 2018;10:1223–31.

Article  CAS  PubMed  Google Scholar 

Bekri S, Gual P, Anty R, Luciani N, Dahman M, Ramesh B, et al. Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH. Gastroenterology. 2006;131:788–96.

Article  CAS  PubMed  Google Scholar 

Kulaksiz H, Fein E, Redecker P, Stremmel W, Adler G, Cetin Y. Pancreatic beta-cells express hepcidin, an iron-uptake regulatory peptide. J Endocrinol. 2008;197:241–9.

Article  CAS  PubMed  Google Scholar 

Oshaug A, Bugge KH, Bjonnes CH, Borchiohnsen B, Neslein IL. Associations between Serum Ferritin and Cardiovascular Risk-Factors in Healthy-Young Men—a Cross-Sectional Study. Eur J Clin Nutr. 1995;49:430–8.

CAS  PubMed  Google Scholar 

Dongiovanni P, Ruscica M, Rametta R, Recalcati S, Steffani L, Gatti S, et al. Dietary iron overload induces visceral adipose tissue insulin resistance. Am J Pathol. 2013;182:2254–63.

Article  CAS  PubMed  Google Scholar 

Valenti L, Remondini E, Fracanzani AL, Spada A, Colombo S, Guzzo A, et al. Effect of iron depletion on liver function and insulin resistance in patients with NASH and fatty liver. Hepatology. 2005;42:619a–20a.

Google Scholar 

Aigner E, Felder TK, Oberkofler H, Hahne P, Auer S, Soyal S, et al. Glucose acts as a regulator of serum iron by increasing serum hepcidin concentrations. J Nutr Biochem. 2013;24:112–7.

Article  CAS  PubMed  Google Scholar 

Varghese J, James JV, Anand R, Narayanasamy M, Rebekah G, Ramakrishna B, et al. Development of insulin resistance preceded major changes in iron homeostasis in mice fed a high-fat diet. J Nutr Biochem. 2020;84:108441.

Article  CAS  PubMed  Google Scholar 

Abbas MA, Abraham D, Kushner JP, McClain DA. Anti-obesity and pro-diabetic effects of hemochromatosis. Obesity. 2014;22:2120–2.

Article  PubMed  Google Scholar 

Oexle H, Gnaiger E, Weiss G. Iron-dependent changes in cellular energy metabolism: influence on citric acid cycle and oxidative phosphorylation. Biochim Biophys Acta. 1999;1413:99–107.

Article  CAS  PubMed  Google Scholar 

Volani C, Doerrier C, Demetz E, Haschka D, Paglia G, Lavdas AA, et al. Dietary iron loading negatively affects liver mitochondrial function. Metallomics. 2017;9:1634–44.

Article  CAS  PubMed  Google Scholar 

Coffey R, Ganz T. Iron homeostasis: An anthropocentric perspective. J Biol Chem. 2017;292:12727–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Andriopoulos B Jr., Corradini E, Xia Y, Faasse SA, Chen S, Grgurevic L, et al. BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nat Genet. 2009;41:482–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Silvestri L, Nai A, Dulja A, Pagani A. Hepcidin and the BMP-SMAD pathway: An unexpected liaison. Vitam Horm. 2019;110:71–99.

Article  CAS  PubMed  Google Scholar 

Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Investig. 2004;113:1271–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ganz T, Nemeth E. Iron homeostasis in host defence and inflammation. Nat Rev Immunol. 2015;15:500–10.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arezes J, Foy N, McHugh K, Sawant A, Quinkert D, Terraube V, et al. Erythroferrone inhibits the induction of hepcidin by BMP6. Blood. 2018;132:1473–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kautz L, Jung G, Valore EV, Rivella S, Nemeth E, Ganz T. Identification of erythroferrone as an erythroid regulator of iron metabolism. Nat Genet. 2014;46:678–84.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wenzel BJ, Stults HB, Mayer J. Hypoferraemia in obese adolescents. Lancet. 1962;2:327–8.

Article  CAS  PubMed  Google Scholar 

Nead KG, Halterman JS, Kaczorowski JM, Auinger P, Weitzman M. Overweight children and adolescents: a risk group for iron deficiency. Pediatrics. 2004;114:104–8.

Article  PubMed  Google Scholar 

Cercamondi CI, Stoffel NU, Moretti D, Zoller T, Swinkels DW, Zeder C, et al. Iron homeostasis during anemia of inflammation: a prospective study of patients with tuberculosis. Blood. 2021;138:1293–303.

Article  CAS  PubMed  Google Scholar 

Tussing-Humphreys LM, Nemeth E, Fantuzzi G, Freels S, Holterman AX, Galvani C, et al. Decreased serum hepcidin and improved functional iron status 6 months after restrictive bariatric surgery. Obesity. 2010;18:2010–6.

Article  CAS  PubMed  Google Scholar 

Vaquero MP, Martinez-Suarez M, Garcia-Quismondo A, del Canizo FJ, Sanchez-Muniz FJ. Diabesity negatively affects transferrin saturation and iron status. The DICARIVA study. Diabetes Res Clin Pract. 2021;172:108653.

Article  Google Scholar 

Lefebvre P, Letois F, Sultan A, Nocca D, Mura T, Galtier F. Nutrient deficiencies in patients with obesity considering bariatric surgery: a cross-sectional study. Surg Obes Relat Dis. 2014;10:540–6.

Article  PubMed  Google Scholar 

Wells JC, Sawaya AL, Wibaek R, Mwangome M, Poullas MS, Yajnik CS, et al. The double burden of malnutrition: aetiological pathways and consequences for health. Lancet. 2020;395:75–88.

Article  PubMed  Google Scholar 

Chambers EC, Heshka S, Gallagher D, Wang J, Pi-Slinyer FX, Pierson RN. Serum iron and body fat distribution in a multiethnic cohort of adults living in New York City. J Am Diet Assoc. 2006;106:680–4.

Article  CAS  PubMed  Google Scholar 

Gillum RF. Association of serum ferritin and indices of body fat distribution and obesity in Mexican American men - the Third National Health and Nutrition Examination Survey. Int J Obesity. 2001;25:639–45.

Article  CAS  Google Scholar 

Iwasaki T, Nakajima A, Yoneda M, Yamada Y, Mukasa K, Fujita K, et al. Serum ferritin is associated with visceral fat area and subcutaneous fat area. Diabetes Care. 2005;28:2486–91.

Article  CAS  PubMed  Google Scholar 

Stoffel NU, El-Mallah C, Herter-Aeberli I, Bissani N, Wehbe N, Obeid O, et al. The effect of central obesity on inflammation, hepcidin, and iron metabolism in young women. Int J Obes. 2020;44:1291–300.

Article  CAS  Google Scholar 

Olefsky JM, Glass CK. Macrophages, inflammation, and insulin resistance. Annu Rev Physiol. 2010;72:219–46.

Article  CAS  PubMed  Google Scholar 

Wrighting DM, Andrews NC. Interleukin-6 induces hepcidin expression through STAT3. Blood. 2006;108:3204–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang Q, Jian J, Katz S, Abramson SB, Huang X. 17beta-Estradiol inhibits iron hormone hepcidin through an estrogen responsive element half-site. Endocrinology. 2012;153:3170–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kawai T, Autieri MV, Scalia R. Adipose tissue inflammation and metabolic dysfunction in obesity. Am J Physiol Cell Physiol. 2021;320:C375–91.

Article  CAS  PubMed  Google Scholar 

Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006;444:860–7.

Article  CAS  PubMed  Google Scholar 

Cepeda-Lopez AC, Allende-Labastida J, Melse-Boonstra A, Osendarp SJ, Herter-Aeberli I, Moretti D, et al. The effects of fat loss after bariatric surgery on inflammation, serum hepcidin, and iron absorption: a prospective 6-mo iron stable isotope study. Am J Clin Nutr. 2016;104:1030–8.

Article  CAS  PubMed  Google Scholar 

Moreno-Navarrete JM, Novelle MG, Catalan V, Ortega F, Moreno M, Gomez-Ambrosi J, et al. Insulin resistance modulates iron-related proteins in adipose tissue. Diabetes Care. 2014;37:1092–100.

Article  CAS  PubMed  Google Scholar 

Tajima S, Ikeda Y, Sawada K, Yamano N, Horinouchi Y, Kihira Y, et al. Iron reduction by deferoxamine leads to amelioration of adiposity via the regulation of oxidative stress and inflammation in obese and type 2 diabetes KKAy mice. Am J Physiol Endocrinol Metab. 2012;302:E77–86.

Article  CAS  PubMed  Google Scholar