Zhou K, Gaullier G, Luger K. Nucleosome structure and dynamics are coming of age. Nat Struct Mol Biol. 2018;26:3–13.

Article  PubMed  PubMed Central  Google Scholar 

Martire S, Banaszynski LA. The roles of histone variants in fine-tuning chromatin organization and function. Nat Rev Mol Cell Biol. 2020;21:522–41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Weber CM, Henikoff S. Histone variants: dynamic punctuation in transcription. Genes Dev. 2014;28:672–82.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Talbert PB, Ahmad K, Almouzni G, Ausió J, Berger F, Bhalla PL, et al. A unified phylogeny-based nomenclature for histone variants. Epigenetics Chromatin. 2012;5:7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goldberg AD, Banaszynski LA, Noh K-M, Lewis PW, Elsaesser SJ, Stadler S, et al. Distinct factors control histone variant H3.3 localization at specific genomic regions. Cell. 2010;140:678–91.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mito Y, Henikoff JG, Henikoff S. Genome-scale profiling of histone H3.3 replacement patterns. Nat Genet. 2005;37:1090–7.

Article  CAS  PubMed  Google Scholar 

Wirbelauer C, Bell O, Schübeler D. Variant histone H3.3 is deposited at sites of nucleosomal displacement throughout transcribed genes while active histone modifications show a promoter-proximal bias. Genes Dev. 2005;19:1761–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lewis PW, Elsaesser SJ, Noh K-M, Stadler SC, Allis CD. Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres. Proc Natl Acad Sci USA. 2010;107:14075–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu G, Broniscer A, McEachron TA, Lu C, Paugh BS, Becksfort J, et al. Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas. Nat Genet. 2012;44:251–3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schwartzentruber J, Korshunov A, Liu XY, Jones DTW, Pfaff E, Jacob K, et al. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature. 2012;482(7384):226–31.

Article  CAS  PubMed  Google Scholar 

Behjati S, Tarpey PS, Presneau N, Scheipl S, Pillay N, Van Loo P, et al. Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone. Nat Genetics. 2013;45:1479–82.

Article  CAS  PubMed  Google Scholar 

Cook AJL, Gurard-Levin ZA, Vassias I, Almouzni G. A specific function for the histone Chaperone NASP to fine-tune a reservoir of soluble H3–H4 in the histone supply chain. Mol Cell. 2011;44:918–27.

Article  CAS  PubMed  Google Scholar 

Alvarez F, Muñoz F, Schilcher P, Imhof A, Almouzni G, Loyola A. Sequential establishment of marks on soluble histones H3 and H4. J Biol Chem. 2011;286:17714–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Campos EI, Fillingham J, Li G, Zheng H, Voigt P, Kuo W-HW, et al. The program for processing newly synthesized histones H3.1 and H4. Nat Struct Mol Biol. 2010;17:1343–51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grover P, Asa JS, Campos EI. H3–H4 histone chaperone pathways. Annu Rev Genet. 2018;52:109–30.

Article  CAS  PubMed  Google Scholar 

Pardal AJ, Fernandes-Duarte F, Bowman AJ. The histone chaperoning pathway: from ribosome to nucleosome. Essays Biochem. 2019;63:29–43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Malay AD, Umehara T, Matsubara-Malay K, Padmanabhan B, Yokoyama S. Crystal structures of fission yeast histone chaperone Asf1 complexed with the Hip1 B-domain or the Cac2 C terminus. J Biol Chem. 2008;283:14022–31.

Article  CAS  PubMed  Google Scholar 

Panne D, Sauer PV, Gu Y, Liu WH, Mattiroli F, Luger K, et al. Mechanistic insights into histone deposition and nucleosome assembly by the chromatin assembly factor-1. Nucleic Acids Res. 2018;46:9907–17.

Article  PubMed  PubMed Central  Google Scholar 

Kaufman PD, Kobayashi R, Stillman B. Ultraviolet radiation sensitivity and reduction of telomeric silencing in Saccharomyces cerevisiae cells lacking chromatin assembly factor-I. Genes Dev. 1997;11:345–57.

Article  CAS  PubMed  Google Scholar 

Balaji S, Iyer LM, Aravind L. HPC2 and ubinuclein define a novel family of histone chaperones conserved throughout eukaryotes. Mol Biosyst. 2009;5:269–75.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rai TS, Puri A, McBryan T, Hoffman J, Tang Y, Pchelintsev NA, et al. Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex. Mol Cell Biol. 2011;31:4107–18.

Article  PubMed  PubMed Central  Google Scholar 

Lin CJ, Koh FM, Wong P, Conti M, Ramalho-Santos M. Hira-mediated H3.3 incorporation is required for DNA replication and ribosomal RNA transcription in the mouse zygote. Dev Cell. 2014;30:268–79.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Formosa T, Ruone S, Adams MD, Olsen AE, Eriksson P, Yu Y, et al. Defects in SPT16 or POB3 (yFACT) in Saccharomyces cerevisiae cause dependence on the Hir/Hpc pathway: polymerase passage may degrade chromatin structure. Genetics. 2002;162:1557–71.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tang Y, Poustovoitov MV, Zhao K, Garfinkel M, Canutescu A, Dunbrack R, et al. Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly. Nat Struct Mol Biol. 2006;13:921–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sakai A, Schwartz BE, Goldstein S, Ahmad K. Transcriptional and developmental functions of the H3.3 histone variant in Drosophila. Curr Biol. 2009;19:1816–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Piazzesi A, Papić D, Bertan F, Salomoni P, Nicotera P, Bano D. Replication-independent histone variant H3.3 controls animal lifespan through the regulation of pro-longevity transcriptional programs. Cell Rep. 2016;17:987.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wollmann H, Stroud H, Yelagandula R, Tarutani Y, Jiang D, Jing L, et al. The histone H3 variant H3.3 regulates gene body DNA methylation in Arabidopsis thaliana. Genome Biol. 2017;18:1.

Article  Google Scholar 

Szenker E, Ray-Gallet D, Almouzni G. The double face of the histone variant H3.3. Cell Res. 2011;21:421–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Orias E, Cervantes MD, Hamilton EP. Tetrahymena thermophila, a unicellular eukaryote with separate germline and somatic genomes. Res Microbiol. 2011;162:578–86.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martindale DW, Allis CD, Bruns PJ. Conjugation in Tetrahymena thermophila. A temporal analysis of cytological stages. Exp Cell Res. 1982;140:227–36.

Article  CAS  PubMed  Google Scholar 

Yao M-CC, Choi J, Yokoyama S, Austerberry CF, Yao C-HH. DNA elimination in Tetrahymena: a developmental process involving extensive breakage and rejoining of DNA at defined sites. Cell. 1984;36:433–40.

Article  CAS  PubMed  Google Scholar 

Mochizuki K, Gorovsky MA. Small RNAs in genome rearrangement in Tetrahymena. Curr Opin Genet Dev. 2004;14:181–7.

Article  CAS  PubMed  Google Scholar 

Mochizuki K, Fine NA, Fujisawa T, Gorovsky MA. Analysis of a piwi-related gene implicates small RNAs in genome rearrangement in tetrahymena. Cell. 2002;110:689–99.

Article  CAS  PubMed  Google Scholar 

Saettone A, Nabeel-Shah S, Garg J, Lambert J-P, Pearlman RE, Fillingham J. Functional proteomics of nuclear proteins in Tetrahymena thermophila: a review. Genes (Basel). 2019;10:333.

Article  CAS  PubMed