Jahromi MM, Eisenbarth GS. Cellular and molecular pathogenesis of type 1A diabetes. Cell Mol Life Sci. 2007;64:865–72.

Article  CAS  PubMed  Google Scholar 

Hyman SJ, Shreffler WG, Rapaport R. Type 1 diabetes, autoimmune thyroid disease, and chronic urticaria. Pediatr Diabetes. 2008;9:508–11.

Article  PubMed  Google Scholar 

Danne T, Lange K, Kordonouri O. New developments in the treatment of type 1 diabetes in children. Arch Dis Child. 2007;92:1015–9.

Article  PubMed  PubMed Central  Google Scholar 

Otto-Buczkowska E, Jarosz-Chobot P, Tucholski K. New developments in the treatment and monitoring of type 1 diabetes mellitus. Endokrynol Pol. 2008;59:246–53.

PubMed  Google Scholar 

Gaglia JL, Shapiro AM, Weir GC. Islet transplantation: progress and challenge. Arch Med Res. 2005;36:273–80.

Article  CAS  PubMed  Google Scholar 

Rickels MR, Fuller C, Dalton-Bakes C, Markmann E, Palanjian M, Cullison K, et al. Teff, restoration of glucose counterregulation by islet transplantation in long-standing type 1 diabetes. Diabetes. 2015;64:1713–8.

Article  CAS  PubMed  Google Scholar 

Robertson RP. Islet transplantation for type 1 diabetes, 2015: what have we learned from alloislet and autoislet successes? Diabetes Care. 2015;38:1030–5.

Article  PubMed  PubMed Central  Google Scholar 

Fu Z, Zhen W, Yuskavage J, Liu D. Epigallocatechin gallate delays the onset of type 1 diabetes in spontaneous non-obese diabetic mice. Br J Nutr. 2011;105:1218–25.

Article  CAS  PubMed  Google Scholar 

Zhao Y, Lin B, Darflinger R, Zhang Y, Holterman MJ, Skidgel RA. Human cord blood stem cell-modulated regulatory T lymphocytes reverse the autoimmune-caused type 1 diabetes in nonobese diabetic (NOD) mice. PLoS One. 2009;4:e4226.

Article  PubMed  PubMed Central  Google Scholar 

Moassesfar S, Masharani U, Frassetto LA, Szot GL, Tavakol M, Stock PG, et al. A comparative analysis of the safety, efficacy, and cost of islet versus pancreas transplantation in nonuremic patients with type 1 diabetes. Am J Transplant. 2016;16:518–26.

Article  CAS  PubMed  Google Scholar 

Zhao L, Xiao Y, Xiao N. Effect of lentinan combined with docetaxel and cisplatin on the proliferation and apoptosis of BGC823 cells. Tumour Biol. 2013;34:1531–6.

Article  CAS  PubMed  Google Scholar 

Konno N, Nakade K, Nishitani Y, Mizuno M, Sakamoto Y. Lentinan degradation in the Lentinula edodes fruiting body during postharvest preservation is reduced by downregulation of the exo-beta-1,3-glucanase EXG2. J Agric Food Chem. 2014;62:8153–7.

Article  CAS  PubMed  Google Scholar 

Bisen PS, Baghel RK, Sanodiya BS, Thakur GS, Prasad GB. Lentinus edodes: a macrofungus with pharmacological activities. Curr Med Chem. 2010;17:2419–30.

Article  CAS  PubMed  Google Scholar 

Yang BK, Kim DH, Jeong SC, Das S, Choi YS, Shin JS, et al. Hypoglycemic effect of a Lentinus edodes exo-polymer produced from a submerged mycelial culture. Biosci Biotechnol Biochem. 2002;66:937–42.

Article  CAS  PubMed  Google Scholar 

Yamac M, Kanbak G, Zeytinoglu M, Bayramoglu G, Senturk H, Uyanoglu M. Hypoglycemic effect of Lentinus strigosus (Schwein.) Fr. crude exopolysaccharide in streptozotocin-induced diabetic rats. J Med Food. 2008;11:513–7.

Article  CAS  PubMed  Google Scholar 

Nishitani Y, Zhang L, Yoshida M, Azuma T, Kanazawa K, Hashimoto T, et al. Intestinal anti-inflammatory activity of lentinan: influence on IL-8 and TNFR1 expression in intestinal epithelial cells. PLoS One. 2013;8:e62441.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wan K. Effects of lentinan of peripheral blood mononuclear cell expression of interleukin-2 receptor in patients with chronic hepatitis B in vivo and in vitro. Hunan Yi Ke Da Xue Xue Bao. 1998;23:90–92.

CAS  PubMed  Google Scholar 

Bao L, Wang Y, Ma R, Ren X, Cheng R, B A. Apoptosis-inducing effects of lentinan on the proliferation of human bladder cancer T24 cells. Pak J Pharm Sci. 2015;28:1595–1600.

CAS  PubMed  Google Scholar 

Sun M, Zhao W, Xie Q, Zhan Y, Wu B. Lentinan reduces tumor progression by enhancing gemcitabine chemotherapy in urothelial bladder cancer. Surg Oncol. 2015;24:28–34.

Article  PubMed  Google Scholar 

Ina K, Kataoka T, Ando T. The use of lentinan for treating gastric cancer. Anticancer Agents Med Chem. 2013;13:681–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ng ML, Yap AT. Inhibition of human colon carcinoma development by lentinan from shiitake mushrooms (Lentinus edodes). J Alter Complement Med. 2002;8:581–9.

Article  Google Scholar 

Liu Y, Zhao J, Zhao Y, Zong S, Tian Y, Chen S, et al. Therapeutic effects of lentinan on inflammatory bowel disease and colitis-associated cancer. J Cell Mol Med. 2019;23:750–60.

Article  CAS  PubMed  Google Scholar 

Kasagi S, Zhang P, Che L, Abbatiello B, Maruyama T, Nakatsukasa H, et al. In vivo-generated antigen-specific regulatory T cells treat autoimmunity without compromising antibacterial immune response. Sci Transl Med. 2014;6:241ra278.

Article  Google Scholar 

Lyons AB. Analysing cell division in vivo and in vitro using flow cytometric measurement of CFSE dye dilution. J Immunol Methods. 2000;243:147–54.

Article  CAS  PubMed  Google Scholar 

Karumuthil-Melethil S, Perez N, Li R, Vasu C. Induction of innate immune response through TLR2 and dectin 1 prevents type 1 diabetes. J Immunol. 2008;181:8323–34.

Article  CAS  PubMed  Google Scholar 

Karumuthil-Melethil S, Gudi R, Johnson BM, Perez N, Vasu C. Fungal beta-glucan, a Dectin-1 ligand, promotes protection from type 1 diabetes by inducing regulatory innate immune response. J Immunol. 2014;193:3308–21.

Article  CAS  PubMed  Google Scholar 

Anderson MS, Bluestone JA. The NOD mouse: a model of immune dysregulation. Annu Rev Immunol. 2005;23:447–85.

Article  CAS  PubMed  Google Scholar 

Akirav EM, Lebastchi J, Galvan EM, Henegariu O, Akirav M, Ablamunits V, et al. Detection of beta cell death in diabetes using differentially methylated circulating DNA. Proc Natl Acad Sci USA. 2011;108:19018–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Salomon B, Lenschow DJ, Rhee L, Ashourian N, Singh B, Sharpe A, et al. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity. 2000;12:431–40.

Article  CAS  PubMed  Google Scholar 

Chanput W, Reitsma M, Kleinjans L, Mes JJ, Savelkoul HF, Wichers HJ. beta-Glucans are involved in immune-modulation of THP-1 macrophages. Mol Nutr Food Res. 2012;56:822–33.

Article  CAS  PubMed  Google Scholar 

Murphy EA, Davis JM, Carmichael MD. Immune modulating effects of beta-glucan. Curr Opin Clin Nutr Metab Care. 2010;13:656–61.

Article  CAS  PubMed  Google Scholar 

Chan GC, Chan WK, Sze DM. The effects of beta-glucan on human immune and cancer cells. J Hematol Oncol. 2009;2:25.

Article  PubMed  PubMed Central  Google Scholar 

Ren L, Perera C, Hemar Y. Antitumor activity of mushroom polysaccharides: a review. Food Funct. 2012;3:1118–30.

Article  CAS  PubMed  Google Scholar 

Yoshida K, Kikutani H. Genetic and immunological basis of autoimmune diabetes in the NOD mouse. Rev Immunogenet. 2000;2:140–6.

CAS  PubMed  Google Scholar 

Pearson JA, Wong FS, Wen L. The importance of the non obese diabetic (NOD) mouse model in autoimmune diabetes. J Autoimmun. 2016;66:76–88.

Article  CAS  PubMed  Google Scholar 

Sakaguchi S. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol. 2005;6:345–52.

Article  CAS  PubMed  Google Scholar 

Sakaguchi S, Setoguchi R, Yagi H, Nomura T. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in self-tolerance and autoimmune disease. Curr Top Microbiol Immunol. 2006;305:51–66.

CAS  PubMed  Google Scholar 

Walker LS, von Herrath M. CD4 T cell differentiation in type 1 diabetes. Clin Exp Immunol. 2016;183:16–29.

Article  CAS  PubMed  Google Scholar