Current status and perspectives of interventional clinical trials for brain metastases: analysis of ClinicalTrials.gov

Sacks P, Rahman M. Epidemiology of brain metastases. Neurosurg Clin N Am. 2020;31:481–8.

Article  PubMed  Google Scholar 

Boire A, Brastianos PK, Garzia L, Valiente M. Brain metastasis. Nat Rev Cancer. 2020;20:4–11.

Article  CAS  PubMed  Google Scholar 

Lamba N, Wen PY, Aizer AA. Epidemiology of brain metastases and leptomeningeal disease. Neuro Oncol. 2021;23:1447–56.

Article  PubMed Central  PubMed  Google Scholar 

le Rhun E, Guckenberger M, Smits M, Dummer R, Bachelot T, Sahm F, et al. EANO–ESMO clinical practice guidelines for diagnosis, treatment and follow-up of patients with brain metastasis from solid tumours. Ann Oncol. 2021;32:1332–47.

Article  PubMed  Google Scholar 

Suh JH, Kotecha R, Chao ST, Ahluwalia MS, Sahgal A, Chang EL. Current approaches to the management of brain metastases. Nat Rev Clin Oncol. 2020;17:279–99.

Article  PubMed  Google Scholar 

Soffietti R, Ahluwalia M, Lin N, Rudà R. Management of brain metastases according to molecular subtypes. Nat Rev Neurol. 2020;16:557–74.

Article  CAS  PubMed  Google Scholar 

Galldiks N, Kocher M, Ceccon G, Werner J-M, Brunn A, Deckert M, et al. Imaging challenges of immunotherapy and targeted therapy in patients with brain metastases: response, progression, and pseudoprogression. Neuro Oncol. 2020;22:17–30.

Article  CAS  PubMed  Google Scholar 

Lau PKH. Brain metastases: lessons and challenges in the targeted therapy and immunotherapy era. J Thorac Dis. 2020;12:4527–30.

Article  PubMed Central  PubMed  Google Scholar 

Sun J, Carr MJ, Khushalani NI. Principles of targeted therapy for melanoma. Surg Clin North Am. 2020;100:175–88.

Article  PubMed  Google Scholar 

Loibl S, Poortmans P, Morrow M, Denkert C, Curigliano G. Breast cancer. Lancet. 2021;397:1750–69.

Article  CAS  PubMed  Google Scholar 

Hirsch FR, Scagliotti GV, Mulshine JL, Kwon R, Curran WJ, Wu Y-L, et al. Lung cancer: current therapies and new targeted treatments. Lancet. 2017;389:299–311.

Article  CAS  PubMed  Google Scholar 

Albittar AA, Alhalabi O, Glitza Oliva IC. Immunotherapy for Melanoma. Adv Exp Med Biol. 2020;1244:51–68.

Emens LA. Breast cancer immunotherapy: facts and hopes. Clin Cancer Res. 2018;24:511–20.

Article  CAS  PubMed  Google Scholar 

Doroshow DB, Sanmamed MF, Hastings K, Politi K, Rimm DL, Chen L, et al. Immunotherapy in non-small cell lung cancer: facts and hopes. Clin Cancer Res. 2019;25:4592–602.

Article  CAS  PubMed Central  PubMed  Google Scholar 

Vanneman M, Dranoff G. Combining immunotherapy and targeted therapies in cancer treatment. Nat Rev Cancer. 2012;12:237–51.

Article  CAS  PubMed Central  PubMed  Google Scholar 

di Giacomo AM, Valente M, Cerase A, Lofiego MF, Piazzini F, Calabrò L, et al. Immunotherapy of brain metastases: breaking a “dogma.” J Exp Clin Cancer Res. 2019;38:419.

Article  PubMed Central  PubMed  Google Scholar 

Petrelli F, de Stefani A, Trevisan F, Parati C, Inno A, Merelli B, et al. Combination of radiotherapy and immunotherapy for brain metastases: a systematic review and meta-analysis. Crit Rev Oncol Hematol. 2019;144: 102830.

Article  PubMed  Google Scholar 

Tallet AV, Dhermain F, le Rhun E, Noël G, Kirova YM. Combined irradiation and targeted therapy or immune checkpoint blockade in brain metastases: toxicities and efficacy. Ann Oncol. 2017;28:2962–76.

Article  CAS  PubMed  Google Scholar 

Koo J, Roh TH, Lee SR, Heo J, Oh Y-T, Kim S-H. Whole-brain radiotherapy vs. localized radiotherapy after resection of brain metastases in the era of targeted therapy: a retrospective study. Cancers (Basel). 2021;13:4711.

Article  CAS  PubMed  Google Scholar 

Rubino S, Oliver DE, Tran ND, Vogelbaum MA, Forsyth PA, Yu H-HM, et al. Improving brain metastases outcomes through therapeutic synergy between stereotactic radiosurgery and targeted cancer therapies. Front Oncol. 2022;12:657.

Article  Google Scholar 

Califf RM. Characteristics of clinical trials registered in ClinicalTrials.gov. JAMA. 2012;307:1838.

Article  CAS  PubMed  Google Scholar 

Becker JE, Ross JS. Reporting discrepancies between the ClinicalTrials.gov results database and peer-reviewed publications. Ann Intern Med. 2014;161:760.

Article  PubMed  Google Scholar 

Tse T, Williams RJ, Zarin DA. Update on registration of clinical trials in ClinicalTrials.gov. Chest. 2009;136:304–5.

Article  PubMed Central  PubMed  Google Scholar 

Gillen JE, Tse T, Ide NC, McCray AT. Design, implementation and management of a web-based data entry system for ClinicalTrials.gov. Stud Health Technol Inform. 2004;107:1466–70.

PubMed  Google Scholar 

Wishart DS. DrugBank: a comprehensive resource for in silico drug discovery and exploration. Nucleic Acids Res. 2006;34:D668–72.

Article  CAS  PubMed  Google Scholar 

Gondi V, Meyer J, Shih HA. Advances in radiotherapy for brain metastases. Neurooncol Adv. 2021;3:v26-34.

PubMed Central  PubMed  Google Scholar 

Nieder C, Andratschke NH, Geinitz H, Grosu AL. Diagnosis-specific graded prognostic assessment score is valid in patients with brain metastases treated in routine clinical practice in two European countries. Med Sci Monit. 2012;18:CR450–5.

Article  PubMed Central  PubMed  Google Scholar 

Schödel P, Jünger ST, Wittersheim M, Reinhardt HC, Schmidt N, Goldbrunner R, et al. Surgical resection of symptomatic brain metastases improves the clinical status and facilitates further treatment. Cancer Med. 2020;9:7503–10.

Article  PubMed Central  PubMed  Google Scholar 

Chao J-H, Phillips R, Nickson JJ. Roentgen-ray therapy of cerebral metastases. Cancer. 1954;7:682–9.

Article  CAS  PubMed  Google Scholar 

Giaj Levra N, Sicignano G, Fiorentino A, Fersino S, Ricchetti F, Mazzola R, et al. Whole brain radiotherapy with hippocampal avoidance and simultaneous integrated boost for brain metastases: a dosimetric volumetric-modulated arc therapy study. Radiol Med. 2016;121:60–9.

Article  PubMed  Google Scholar 

https://clinicaltrials.gov/ct2/show/NCT04804644.

https://clinicaltrials.gov/ct2/show/NCT04277403.

https://clinicaltrials.gov/ct2/show/NCT05045950.

https://clinicaltrials.gov/ct2/show/NCT04801342.

https://clinicaltrials.gov/ct2/show/NCT03550391.

Mathis NJ, Wijetunga NA, Imber BS, Pike LRG, Yang JT. Recent advances and applications of radiation therapy for brain metastases. Curr Oncol Rep. 2022;24:335–42.

Article  CAS  PubMed  Google Scholar 

Zindler JD, Bruynzeel AME, Eekers DBP, Hurkmans CW, Swinnen A, Lambin P. Whole brain radiotherapy versus stereotactic radiosurgery for 4–10 brain metastases: a phase III randomised multicentre trial. BMC Cancer. 2017;17:500.

Article  PubMed Central  PubMed  Google Scholar 

Ruggieri R, Naccarato S, Mazzola R, Ricchetti F, Corradini S, Fiorentino A, et al. Linac-based radiosurgery for multiple brain metastases: comparison between two mono-isocenter techniques with multiple non-coplanar arcs. Radiother Oncol. 2019;132:70–8.

Article  PubMed  Google Scholar 

https://clinicaltrials.gov/ct2/show/NCT04422639.

https://clinicaltrials.gov/ct2/show/NCT04365374.

https://clinicaltrials.gov/ct2/show/NCT05124236.

https://clinicaltrials.gov/ct2/show/NCT03075072.

https://clinicaltrials.gov/ct2/show/NCT03769103.

https://clinicaltrials.gov/ct2/show/NCT02736513.

https://clinicaltrials.gov/ct2/show/NCT05104281.

https://clinicaltrials.gov/ct2/show/NCT02971501.

https://www.clinicaltrials.gov/ct2/show/NCT03497767.

https://clinicaltrials.gov/ct2/show/NCT03257124.

https://clinicaltrials.gov/ct2/show/NCT04233021.

https://clinicaltrials.gov/ct2/show/NCT04639271.

https://clinicaltrials.gov/ct2/show/NCT03691051.

https://clinicaltrials.gov/ct2/show/NCT03933982.

https://clinicaltrials.gov/ct2/show/NCT04582968.

https://clinicaltrials.gov/ct2/show/NCT05042791.

Jerusalem G, Park YH, Hurvitz SA, Modi S, Andre F et al. Trastuzumab Deruxtecan in HER2-positive metastatic breast cancer patients with brain metastases: a DESTINY-Breast01 subgroup analysis. Cancer Discov. 2022;12:2754–62.

https://clinicaltrials.gov/ct2/show/NCT04752059.

https://clinicaltrials.gov/ct2/show/NCT04739761.

https://clinicaltrials.gov/ct2/show/NCT04420598.

https://clinicaltrials.gov/ct2/show/NCT04538742.

Forsyth PA, Smalley KSM, Sondak VK. BRAF-MEK inhibition in melanoma brain metastases: a new hope. Lancet Oncol. 2017;18:836–7.

Article  PubMed  Google Scholar 

Davies MA, Saiag P, Robert C, Grob J-J, Flaherty KT, Arance A, et al. Dabrafenib plus trametinib in patients with BRAFV600-mutant melanoma brain metastases (COMBI-MB): a multicentre, multicohort, open-label, phase 2 trial. Lancet Oncol. 2017;18:863–73.

Article  CAS  PubMed Central  PubMed 

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