Organization WH. World Health Organization definition of pallitive care [Internet]. 2022 [cited 2021 Oct 12]. Available from: https://www.who.int/health-topics/palliative-care

Rao VB, Belanger E, Egan PC, Leblanc TW, Olszewski AJ. Early palliative care services and end-of-life care in medicare beneficiaries with hematologic malignancies: a population-based retrospective cohort study. J Palliat Med. 2021;24(1):63–70.

Article  PubMed  Google Scholar 

Quill TE, Abernethy AP. Generalist plus specialist palliative care — creating a more sustainable model — NEJM. N Engl J Med [Internet]. 2013;1175–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23465068%5Cnhttp://www.nejm.org/doi/full/https://doi.org/10.1056/NEJMp1215620

LeBlanc TW, Roeland EJ, El-Jawahri A. Early palliative care for patients with hematologic malignancies: is it really so difficult to achieve? Curr Hematol Malig Rep. 2017;12(4):300–8.

Article  PubMed  Google Scholar 

Bakitas M, Lyons K, Hegel MT, et al. Effects of a palliative care intervention on clinical outcomes in patients with advanced cancer: the project enable ii randomized controlled trial. JAMA [Internet]. 2009;302(7):741–9. https://doi.org/10.1001/jama.2009.1198.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Temel JS, Greer JA, Muzikansky A, Gallagher ER, Admane S, Jackson VA, et al. Early palliative care for patients with metastatic non–small-cell lung cancer. N Engl J Med [Internet]. 2010;363(8):733–42. https://doi.org/10.1056/NEJMoa1000678.

Article  CAS  PubMed  Google Scholar 

Bakitas MA, Tosteson TD, Li Z, Lyons KD, Hull JG, Li Z, et al. Early versus delayed initiation of concurrent palliative oncology care: patient outcomes in the ENABLE III randomized controlled trial. J Clin Oncol. 2015;33(13):1438–45.

Article  PubMed  PubMed Central  Google Scholar 

Dionne-Odom JN, Azuero A, Lyons KD, Hull JG, Tosteson T, Li Z, et al. Benefits of early versus delayed palliative care to informal family caregivers of patients with advanced cancer: outcomes from the ENABLE III randomized controlled trial. J Clin Oncol [Internet]. 2015;33(13):1446–52. https://doi.org/10.1200/JCO.2014.58.7824.

Article  PubMed  Google Scholar 

Fulton JJ, LeBlanc TW, Cutson TM, Starr KNP, Kamal A, Ramos K et al. 2019 Integrated outpatient palliative care for patients with advanced cancer: a systematic review and meta-analysis Palliat Med 33 2 123 134 Important systematic review which discusses the integration of palliative care into standard hematologic malignancy care

Zimmermann C, Riechelmann R, Krzyzanowska M, Rodin G, Tannock I. Effectiveness of specialized palliative care: a systematic review. JAMA [Internet]. 2008;299(14):1698–709. https://doi.org/10.1001/jama.299.14.1698.

Article  CAS  PubMed  Google Scholar 

Kavalieratos D, Corbelli J, Zhang D, Dionne-Odom JN, Ernecoff NC, Hanmer J, et al. Association between palliative care and patient and caregiver outcomes: a systematic review and meta-analysis. JAMA [Internet]. 2016;316(20):2104–14. https://doi.org/10.1001/jama.2016.16840.

Article  PubMed  Google Scholar 

Levy MH, Back A, Benedetti C, Billings JA, Block S, Boston B, et al. Palliative Care. J Natl Compr Cancer Netw J Natl Compr Canc Netw [Internet]. 2009;7(4):436–73. Available from: https://jnccn.org/view/journals/jnccn/7/4/article-p436.xml

Jordan K, Aapro M, Kaasa S, Ripamonti CI, Scotté F, Strasser F, et al. European Society for Medical Oncology (ESMO) position paper on supportive and palliative care. Ann Oncol [Internet]. 2018;29(1):36–43. https://doi.org/10.1093/annonc/mdx757.

Article  CAS  PubMed  Google Scholar 

Society ON. Oncology Nursing Society. Palliative Care

Ferrell BR, Temel JS, Temin S, Alesi ER, Balboni TA, Basch EM, et al. Integration of palliative care into standard oncology care: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol [Internet]. 2016;JCO.2016.70.1474. Available from: http://ascopubs.org/doi/abs/https://doi.org/10.1200/JCO.2016.70.1474

Manitta V, Zordan R, Cole-Sinclair M, Nandurkar H, Philip J. The symptom burden of patients with hematological malignancy: a cross-sectional observational study. J Pain Symptom Manage [Internet]. 2011;42(3):432–42. https://doi.org/10.1016/j.jpainsymman.2010.12.008.

Article  PubMed  Google Scholar 

Fadul NA, El OB, Dalal S, Poulter VA, Bruera E. Comparison of symptom burden among patients referred to palliative care with hematologic malignancies versus those with solid tumors. J Palliat Med [Internet]. 2008;11(3):422–7. https://doi.org/10.1089/jpm.2007.0184.

Article  PubMed  Google Scholar 

Hochman MJ, Yu Y, Wolf SP, Samsa GP, Kamal AH, LeBlanc TW. Comparing the palliative care needs of patients with hematologic and solid malignancies. J Pain Symptom Manage [Internet]. 2018;55(1):82-88.e1. https://doi.org/10.1016/j.jpainsymman.2017.08.030.

Article  PubMed  Google Scholar 

El-Jawahri A, Nelson AM, Gray TF, Lee SJ, LeBlanc TW. Palliative and end-of-life care for patients with hematologic malignancies. J Clin Oncol. 2020;38(9):944–53.

Article  PubMed  PubMed Central  Google Scholar 

Bergerot CD, Clark KL, Nonino A, Waliany S, Buso MM, Loscalzo M. Course of distress, anxiety, and depression in hematological cancer patients: association between gender and grade of neoplasm. Palliat Support Care [Internet] 2015 2013/11/04;13(2):115–23. Available from: https://www.cambridge.org/core/article/course-of-distress-anxiety-and-depression-in-hematological-cancer-patients-association-between-gender-and-grade-of-neoplasm/CF918569D7E6E4E35B8A99A65396CA4F

Detmar SB, Aaronson NK, Wever LDV, Muller M, Schornagel JH. How are you feeling? Who wants to know? Patients’ and oncologists’ preferences for discussing health-related quality-of-life issues. J Clin Oncol [Internet]. 2000;18(18):3295–301. https://doi.org/10.1200/JCO.2000.18.18.3295.

Article  CAS  PubMed  Google Scholar 

Pollak KI, Arnold RM, Jeffreys AS, Alexander SC, Olsen MK, Abernethy AP, et al. Oncologist communication about emotion during visits with patients with advanced cancer. J Clin Oncol [Internet]. 2007;25(36):5748–52. https://doi.org/10.1200/JCO.2007.12.4180.

Article  PubMed  Google Scholar 

Temel JS, Greer JA, Admane S, Solis J, Cashavelly BJ, Doherty S, et al. Code status documentation in the outpatient electronic medical records of patients with metastatic cancer. J Gen Intern Med [Internet]. 2010;25(2):150–3. https://doi.org/10.1007/s11606-009-1161-z.

Article  PubMed  Google Scholar 

Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69:7–34.

Article  PubMed  Google Scholar 

Chino F, Kamal AH, Chino J, LeBlanc TW. Disparities in place of death for patients with hematological malignancies, 1999 to 2015. Blood Adv [Internet]. 2019;3(3):333–8. https://doi.org/10.1182/bloodadvances.2018023051.

Article  PubMed  Google Scholar 

Egan PC, LeBlanc TW, Olszewski AJ. End-of-life care quality outcomes among Medicare beneficiaries with hematologic malignancies. Blood Adv [Internet]. 2020;4(15):3606–14. https://doi.org/10.1182/bloodadvances.2020001767.

Article  PubMed  Google Scholar 

Lowe JR, Yu Y, Wolf S, Samsa G, LeBlanc TW. A cohort study of patient-reported outcomes and healthcare utilization in acute myeloid leukemia patients receiving active cancer therapy in the last six months of life. J Palliat Med [Internet]. 2018;21(5):592–7. https://doi.org/10.1089/jpm.2017.0463.

Article  PubMed  Google Scholar 

Epstein AS, Goldberg GR, Meier DE. Palliative care and hematologic oncology: the promise of collaboration. Blood Rev [Internet]. 2012.26(6):233–9. Available from: https://www.sciencedirect.com/science/article/pii/S0268960X12000495

Wang R, Zeidan AM, Halene S, Xu X, Davidoff AJ, Huntington SF, et al. Health care use by older adults with acute myeloid leukemia at the end of life. J Clin Oncol [Internet]. 2017;35(30):3417–24. https://doi.org/10.1200/JCO.2017.72.7149.

Article  PubMed  Google Scholar 

LeBlanc TW. Advance care planning and palliative care specialists in malignant hematology and stem-cell transplantation: on why it takes a village. J Oncol Pract [Internet]. 2017;14(1):3–5. https://doi.org/10.1200/JOP.2017.026930.

Article  PubMed  Google Scholar 

LeBlanc TW, Egan PC, Olszewski AJ. Transfusion dependence, use of hospice services, and quality of end-of-life care in leukemia. Blood [Internet]. 2018;132(7):717–26. https://doi.org/10.1182/blood-2018-03-842575.

Article  CAS  PubMed  Google Scholar 

Oreofe O. Odejide, Ling Li, Angel M. Cronin, Anays Murillo, Paul G. Richardson, Kenneth C. Anderson, et al. Meaningful changes in end-of-life care among patients with myeloma. Haematologica [Internet]. 2018.103(8 SE-Articles):1380–9. Available from: https://haematologica.org/article/view/8560

Schulz-Kindermann F, Mehnert A, Scherwath A, Schirmer L, Schleimer B, Zander AR, et al. Cognitive function in the acute course of allogeneic hematopoietic stem cell transplantation for hematological malignancies. Bone Marrow Transplant [Internet]. 2007;39(12):789–99. https://doi.org/10.1038/sj.bmt.1705663.

Article  CAS  PubMed  Google Scholar 

Tzelepis F, Paul CL, Sanson-Fisher RW, Campbell HS, Bradstock K, Carey ML, et al. Unmet supportive care needs of haematological cancer survivors: rural versus urban residents. Ann Hematol [Internet]. 2018;97(7):1283–92. https://doi.org/10.1007/s00277-018-3285-x.

Article  CAS  PubMed  Google Scholar 

Damlaj M, El Fakih R, Hashmi SK. Evolution of survivorship in lymphoma, myeloma and leukemia: metamorphosis of the field into long term follow-up care. Blood Rev [Internet]. 2019;33:63–73. Available from: https://www.sciencedirect.com/science/article/pii/S0268960X18300353

LeBlanc TW, Roeland EJ, El-Jawahri A. Early palliative care for patients with hematologic malignancies: is it really so difficult to achieve? Curr Hematol Malig Rep [Internet]. 2017;12(4):300–8. https://doi.org/10.1007/s11899-017-0392-z.

Article  PubMed  Google Scholar 

Kayastha N, LeBlanc TW. Why are we failing to do what works? Musings on outpatient palliative care integration in cancer care. JCO Oncol Pract [Internet]. 2021;18(4):255–7. https://doi.org/10.1200/OP.21.00794.

Article  PubMed  Google Scholar 

Kayastha N, LeBlanc TW. Palliative care for patients with hematologic malignancies: are we meeting patients’ needs early enough? Expert Rev Hematol [Internet]. 2022;15(9):813–20. https://doi.org/10.1080/17474086.2022.2121696.

Article  CAS  PubMed  Google Scholar 

Kayastha N, LeBlanc TW. When to integrate palliative care in the trajectory of cancer care. Curr Treat Options Oncol. 2020;21(5).

LeBlanc TW, El-Jawahri A. Hemato-oncology and palliative care teams: is it time for an integrated approach to patient care? Curr Opin Support Palliat Care [Internet]. 2018;12(4). Available from: https://journals.lww.com/co-supportiveandpalliativecare/Fulltext/2018/12000/Hemato_oncology_and_palliative_care_teams__is_it.23.aspx

Gatta B, LeBlanc TW. Palliative care in hematologic malignancies: a multidisciplinary approach. Expert Rev Hematol [Internet]. 2020;13(3):223–31. https://doi.org/10.1080/17474086.2020.1728248.

Article  CAS  PubMed  Google Scholar 

Prod’homme C, Jacquemin D, Touzet L, Aubry R, Daneault S, Knoops L. Barriers to end-of-life discussions among hematologists: a qualitative study. Palliat Med [Internet]. 2018;32(5):1021–9. https://doi.org/10.1177/0269216318759862.

Article  PubMed  Google Scholar 

Resick JM, Sefcik C, Arnold RM, LeBlanc TW, Bakitas M, Rosenzweig MQ, et al. Primary palliative care for patients with advanced hematologic malignancies: a pilot trial of the SHARE intervention. J Palliat Med [Internet]. 2020;24(6):820–9. https://doi.org/10.1089/jpm.2020.0407.

Article  Google Scholar 

El-Jawahri A, LeBlanc TW, Burns LJ, Denzen E, Meyer C, Mau L-W, et al. What do transplant physicians think about palliative care? A national survey study. Cancer [Internet]. 2018;124(23):4556–66. https://doi.org/10.1002/cncr.31709.

Article  PubMed  Google Scholar 

LeBlanc TW, Erba HP. Shifting paradigms in the treatment of older adults with AML. Semin Hematol [Internet]. 2019;56(2):110–7. Available from: https://www.sciencedirect.com/science/article/pii/S003719631930006X

LeBlanc TW, Marron JM, Ganai S, McGinnis MM, Spence RA, Tenner L, et al. Prognostication and communication in oncology. J Oncol Pract. 2019;15(7):208–15.