Cai B, Song XQ, Cai JP, Zhang S. HOTAIR: a cancer-related long non-coding RNA. Neoplasma. 2014;61(4):379–91.

Article  CAS  PubMed  Google Scholar 

Liu XH, Sun M, Nie FQ, Ge YB, Zhang EB, Yin DD, Kong R, Xia R, Lu KH, Li JH, et al. Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging mir-331-3p in gastric cancer. Mol Cancer. 2014;13:92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Biswas S, Feng B, Chen S, Liu J, Aref-Eshghi E, Gonder J, Ngo V, Sadikovic B, Chakrabarti S. The long non-coding RNA HOTAIR is a critical epigenetic mediator of angiogenesis in diabetic retinopathy. Invest Ophthalmol Vis Sci. 2021;62(3):20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Botti G, Collina F, Scognamiglio G, Aquino G, Cerrone M, Liguori G, Gigantino V, Malzone MG, Cantile M. LncRNA HOTAIR polymorphisms association with cancer susceptibility in different tumor types. Curr Drug Targets. 2018;19(10):1220–26.

Article  CAS  PubMed  Google Scholar 

Miao Z, Ding J, Chen B, Yang Y, Chen Y. HOTAIR overexpression correlated with worse survival in patients with solid tumors. Minerva Med. 2016;107(6):392–400.

PubMed  Google Scholar 

Weng SL, Wu WJ, Hsiao YH, Yang SF, Hsu CF, Wang PH. Significant association of long non-coding RNAs HOTAIR genetic polymorphisms with cancer recurrence and patient survival in patients with uterine cervical cancer. Int J Med Sci. 2018;15(12):1312–19.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Yi K, Liu X, Tan Y, Jin W, Li Y, Zhou J, Wang H, Kang C. HOTAIR up-regulation activates NF-κB to induce immunoescape in gliomas. Front Immunol. 2021;12:785463.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hui Z, Xianglin M. Association of HOTAIR expression with PI3K/Akt pathway activation in adenocarcinoma of esophagogastric junction. Open Med (Wars). 2016;11(1):36–40.

Article  CAS  PubMed  Google Scholar 

Wei Z, Chen L, Meng L, Han W, Huang L, Xu A. LncRNA HOTAIR promotes the growth and metastasis of gastric cancer by sponging mir-1277-5p and upregulating COL5A1. Gastric Cancer. 2020;23(6):1018–32.

Article  CAS  PubMed  Google Scholar 

Zhang JX, Han L, Bao ZS, Wang YY, Chen LY, Yan W, Yu SZ, Pu PY, Liu N, You YP, et al. HOTAIR, a cell cycle-associated long noncoding RNA and a strong predictor of survival, is preferentially expressed in classical and mesenchymal glioma. Neuro Oncol. 2013;15(12):1595–603.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou X, Chen J, Tang W. The molecular mechanism of HOTAIR in tumorigenesis, metastasis, and drug resistance. Acta Biochim Biophys Sin. 2014;46(12):1011–15.

Article  CAS  PubMed  Google Scholar 

Jing L, Yuan W, Ruofan D, Jinjin Y, Haifeng Q. HOTAIR enhanced aggressive biological behaviors and induced radio-resistance via inhibiting p21 in cervical cancer. Tumour Biol. 2015;36(5):3611–19.

Article  PubMed  Google Scholar 

Li T, Liu N, Gao Y, Quan Z, Hao Y, Yu C, Li L, Yuan M, Niu L, Luo C, Wu X. Long noncoding RNA HOTAIR regulates the invasion and metastasis of prostate cancer by targeting hepaCAM. Br J Cancer. 2021;124(1):247–58.

Article  CAS  PubMed  Google Scholar 

Fu WM, Lu YF, Hu BG, Liang WC, Zhu X, Yang HD, Li G, Zhang JF. Long noncoding RNA HOTAIR mediated angiogenesis in nasopharyngeal carcinoma by direct and indirect signaling pathways. Oncotarget. 2016;7(4):4712–23.

Article  PubMed  Google Scholar 

Price RL, Bhan A, Mandal SS. HOTAIR beyond repression: in protein degradation, inflammation, DNA damage response, and cell signaling. DNA Repair (Amst). 2021;105:103141.

Article  CAS  PubMed  Google Scholar 

Ni SY, Xu WT, Liao GY, Wang YL, Li J. LncRNA HOTAIR promotes LPS-induced inflammation and apoptosis of cardiomyocytes via Lin28-mediated PDCD4 stability. Inflammation. 2021;44(4):1452–63.

Article  CAS  PubMed  Google Scholar 

Chen J, Hou S-F, Tang F-J, Liu D-S, Chen Z-Z, Zhang H-L, Wang S-H. HOTAIR/Sp1/miR-199a critically regulates cancer stemness and malignant progression of cutaneous squamous cell carcinoma. Oncogene. 2022;41(1):99–111.

Article  CAS  PubMed  Google Scholar 

Wang B-r, Chu D-x, Cheng M-y, Jin Y. Luo H-g, Li N. Progress of HOTAIR-microRNA in hepatocellular carcinoma. Hered Cancer Clin Pract. 2022;20(1):1–10.

Article  Google Scholar 

Delhaye L, De Bruycker E, Volders P-J, Fijalkowska D, De Sutter D, Degroeve S, Martens L, Mestdagh P, Eyckerman S. Orthogonal proteomics methods to unravel the HOTAIR interactome. Sci Rep. 2022;12(1):1–11.

Article  Google Scholar 

Bossaghzadeh F, Hajjari M, Sheikhi A, Salahshourifar I, Irani S. HOTAIR induces the downregulation of miR-200 family members in gastric cancer cell lines. Iran Biomed J. 2022;26(1):77.

PubMed  Google Scholar 

Yao J, Ma R, Wang C, Zhao G. LncRNA-HOTAIR inhibits H9c2 apoptosis after acute myocardial infarction via miR-206/FN1 axis. Biochem Genet. 2022;60:1781–92.

Angelopoulou E, Paudel YN, Piperi C. Critical role of HOX transcript antisense intergenic RNA (HOTAIR) in gliomas. J Mol Med (Berl). 2020;98(11):1525–46.

Article  CAS  PubMed  Google Scholar 

Yang L, Peng X, Li Y, Zhang X, Ma Y, Wu C, Fan Q, Wei S, Li H, Liu J. Long non-coding RNA HOTAIR promotes exosome secretion by regulating RAB35 and SNAP23 in hepatocellular carcinoma. Mol Cancer. 2019;18(1):1–12.

Article  PubMed  PubMed Central  Google Scholar 

Zhang J, Qiu W-q, Zhu H, Liu H, Sun J-h, Chen Y, Shen H, Qian C-l. Shen Z-y. HOTAIR contributes to the carcinogenesis of gastric cancer via modulating cellular and exosomal miRNAs level. Cell Death Dis. 2020;11(9):780.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang L, Peng X, Li Y, Zhang X, Ma Y, Wu C, Fan Q, Wei S, Li H, Liu J. Long non-coding RNA HOTAIR promotes exosome secretion by regulating RAB35 and SNAP23 in hepatocellular carcinoma. Mol Cancer. 2019;18(1):78.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hajjari M, Salavaty A. HOTAIR: an oncogenic long non-coding RNA in different cancers. Cancer Biol Med. 2015;12(1):1–9.

CAS  PubMed  PubMed Central  Google Scholar 

Shi Y, Huang Q, Kong X, Zhao R, Chen X, Zhai Y, Xiong L. Current knowledge of long non-coding RNA HOTAIR in breast cancer progression and its application. Life (Basel). 2021;11(6):483.

Aranza-Martínez A, Sánchez-Pérez J, Brito-Elias L, López-Camarillo C, de Cantú D, Pérez-Plasencia C, López-Urrutia E. Non-coding RNAs Associated with Radioresistance in Triple-Negative breast Cancer. Front Oncol. 2021;11:752270.

Article  PubMed  PubMed Central  Google Scholar 

Pawłowska E, Szczepanska J, Blasiak J. The long noncoding RNA HOTAIR in breast cancer: does autophagy play a role? Int J Mol Sci. 2017;18(11):2317.

Bhan A, Hussain I, Ansari KI, Bobzean SA, Perrotti LI, Mandal SS. Bisphenol-A and diethylstilbestrol exposure induces the expression of breast cancer associated long noncoding RNA HOTAIR in vitro and in vivo. J Steroid Biochem Mol Biol. 2014;141:160–70.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang G, Zhang S, Gao F, Liu Z, Lu M, Peng S, Zhang T, Zhang F. Osteopontin enhances the expression of HOTAIR in cancer cells via IRF1. Biochim Biophys Acta. 2014;1839(9):837–48.

Article  CAS  PubMed  Google Scholar 

Mozdarani H, Ezzatizadeh V, Rahbar Parvaneh R. The emerging role of the long non-coding RNA HOTAIR in breast cancer development and treatment. J Transl Med. 2020;18(1):152.

Article  CAS  PubMed  PubMed Central  Google Scholar 

He H, Wei Z, Du F, Meng C, Zheng D, Lai Y, Yao H, Zhou H, Wang N, Luo XG, et al. Transcription of HOTAIR is regulated by RhoC-MRTF-A-SRF signaling pathway in human breast cancer cells. Cell Signal. 2017;31:87–95.

Article  CAS  PubMed  Google Scholar 

Milevskiy MJ, Al-Ejeh F, Saunus JM, Northwood KS, Bailey PJ, Betts JA, McCart Reed AE, Nephew KP, Stone A, Gee JM, et al. Long-range regulators of the lncRNA HOTAIR enhance its prognostic potential in breast cancer. Hum Mol Genet. 2016;25(15):3269–83.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tokgun PE, Tokgun O, Kurt S, Tomatir AG, Akca H. MYC-driven regulation of long non-coding RNA profiles in breast cancer cells. Gene. 2019;714:143955.

Article  CAS  PubMed  Google Scholar 

Li Y, Wang Z, Shi H, Li H, Li L, Fang R, Cai X, Liu B, Zhang X, Ye L. HBXIP and LSD1 scaffolded by lncRNA HOTAIR mediate transcriptional activation by c-Myc. Cancer Res. 2016;76(2):293–304.

Article  CAS  PubMed  Google Scholar 

Sun S, Wu Y, Guo W, Yu F, Kong L, Ren Y, Wang Y, Yao X, Jing C, Zhang C, et al. STAT3/HOTAIR signaling axis regulates HNSCC growth in an EZH2-dependent manner. Clin Cancer Res. 2018;24(11):2665–77.

Article  CAS  PubMed  Google Scholar