Comparing gene expression in deep infiltrating endometriosis with adenomyosis uteri: evidence for dysregulation of oncogene pathways

Giudice LC. Clinical practice. Endometriosis. N Engl J Med. 2010;362(25):2389–98.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Meuleman C, Vandenabeele B, Fieuws S, Spiessens C, Timmerman D, D’Hooghe T. High prevalence of endometriosis in infertile women with normal ovulation and normospermic partners. Fertil Steril. 2009;92(1):68–74.

Article  PubMed  Google Scholar 

Chapron C, Fauconnier A, Vieira M, Barakat H, Dousset B, Pansini V et al. Anatomical distribution of deeply infiltrating endometriosis: surgical implications and proposition for a classification.Human Reproduction. 2003;18:157–61.

Devlieger R, D’Hooghe T, Timmerman D. Uterine adenomyosis in the infertility clinic. Hum Reprod Update. 2003;9(2):139–47.

Article  PubMed  Google Scholar 

Garcia-Solares J, Donnez J, Donnez O, Dolmans MM. Pathogenesis of uterine adenomyosis: invagination or metaplasia? Fertil Steril. 2018;109(3):371–9.

Article  PubMed  Google Scholar 

Yeniel O, Cirpan T, Ulukus M, Ozbal A, Gundem G, Ozsener S, et al. Adenomyosis: prevalence, risk factors, symptoms and clinical findings. Clin Exp Obstet Gynecol. 2007;34(3):163–7.

CAS  PubMed  Google Scholar 

Cornillie FJ, Oosterlynck D, Lauweryns JM, Koninckx PR. Deeply infiltrating pelvic endometriosis: histology and clinical significance. Fertil Steril. 1990;53(6):978–83.

Article  CAS  PubMed  Google Scholar 

Chapron C, Tosti C, Marcellin L, Bourdon M, Lafay-Pillet MC, Millischer AE, et al. Relationship between the magnetic resonance imaging appearance of adenomyosis and endometriosis phenotypes. Hum Reprod. 2017;32(7):1393–401.

Article  PubMed  Google Scholar 

Vannuccini S, Clifton VL, Fraser IS, Taylor HS, Critchley H, Giudice LC, et al. Infertility and reproductive disorders: impact of hormonal and inflammatory mechanisms on pregnancy outcome. Hum Reprod Update. 2016;22(1):104–15.

Article  CAS  PubMed  Google Scholar 

Hashimoto A, Iriyama T, Sayama S, Nakayama T, Komatsu A, Miyauchi A, et al. Adenomyosis and adverse perinatal outcomes: increased risk of second trimester miscarriage, preeclampsia, and placental malposition. J Matern Fetal Neonatal Med. 2018;31(3):364–9.

Article  PubMed  Google Scholar 

Inoue S, Hirota Y, Ueno T, Fukui Y, Yoshida E, Hayashi T, et al. Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations. Nat Commun. 2019;10(1):5785.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Parazzini F, Vercellini P, Panazza S, Chatenoud L, Oldani S, Crosignani PG. Risk factors for adenomyosis. Hum Reprod. 1997;12(6):1275–9.

Article  CAS  PubMed  Google Scholar 

Vercellini P, Vigano P, Somigliana E, Daguati R, Abbiati A, Fedele L. Adenomyosis: epidemiological factors. Best Pract Res Clin Obstet Gynaecol. 2006;20(4):465–77.

Article  PubMed  Google Scholar 

Templeman C, Marshall SF, Ursin G, Horn-Ross PL, Clarke CA, Allen M, et al. Adenomyosis and endometriosis in the California Teachers Study. Fertil Steril. 2008;90(2):415–24.

Article  PubMed  Google Scholar 

Anglesio MS, Papadopoulos N, Ayhan A, Nazeran TM, Noe M, Horlings HM, et al. Cancer-Associated mutations in endometriosis without Cancer. N Engl J Med. 2017;376(19):1835–48.

Article  PubMed  PubMed Central  Google Scholar 

Gordts S, Koninckx P, Brosens I. Pathogenesis of deep endometriosis. Fertil Steril. 2017;108(6):872–85. e1.

Article  PubMed  Google Scholar 

Suda K, Nakaoka H, Yoshihara K, Ishiguro T, Tamura R, Mori Y, et al. Clonal expansion and diversification of Cancer-Associated mutations in endometriosis and normal endometrium. Cell Rep. 2018;24(7):1777–89.

Article  CAS  PubMed  Google Scholar 

Moore L, Leongamornlert D, Coorens THH, Sanders MA, Ellis P, Dentro SC, et al. mutational Landsc normal Hum endometrial epithelium. 2020;580(7805):640–6.

CAS  Google Scholar 

Koninckx PR, Ussia A, Adamyan L, Wattiez A, Gomel V, Martin DC. Pathogenesis of endometriosis: the genetic/epigenetic theory. Fertil Steril. 2019;111(2):327–40.

Article  CAS  PubMed  Google Scholar 

Cesano A. nCounter((R)) PanCancer Immune Profiling Panel (NanoString Technologies, Inc., Seattle, WA). J Immunother Cancer. 2015;3:42.

Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 2002;3(7):RESEARCH0034.

Article  PubMed  PubMed Central  Google Scholar 

Smyth GK. Limma: Linear Models for microarray data. In: Gentleman R, Carey V, Dudoit S, Irizarry R, Huber W, editors. Bioinformatics and Computational Biology solutions using R and Bioconductor. Statistics for Biology and Health. Berlin, Heidelberg, New York: Springer; 2005. pp. 397–420.

Google Scholar 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, et al. Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43(7):e47.

Article  PubMed  PubMed Central  Google Scholar 

Benjamini Y, Hochberg Y. Controlling the false Discovery Rate - a practical and powerful Approach to multiple testing. J R Stat Soc B. 1995;57(1):289–300.

Google Scholar 

Huang da W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009;4(1):44–57.

Article  PubMed  Google Scholar 

Huang da W, Sherman BT, Lempicki RA. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 2009;37(1):1–13.

Article  PubMed  Google Scholar 

Fresno C, Fernandez EA. RDAVIDWebService: a versatile R interface to DAVID. Bioinformatics. 2013;29(21):2810–1.

Article  CAS  PubMed  Google Scholar 

R Core Team. R: A language and environment for statistical computing. Date of access: 20.05.2020. Available from: https://www.R-project.org.

McKinnon BD, Kocbek V, Nirgianakis K, Bersinger NA, Mueller MD. Kinase signalling pathways in endometriosis: potential targets for non-hormonal therapeutics. Hum Reprod Update. 2016;22(3):382–403.

Article  CAS  PubMed  Google Scholar 

Matsuzaki S, Canis M, Mage G. Use of laser capture microdissection in studying hormone-dependent diseases: endometriosis. Methods Mol Biol. 2009;590:295–306.

Article  CAS  PubMed  Google Scholar 

Gymnopoulos M, Elsliger M-A, Vogt PK. Rare cancer-specific mutations in PIK3CA show gain of function. Proceedings of the National Academy of Sciences. 2007;104.

Bulun SE, Yildiz S, Adli M, Wei J-J. Adenomyosis pathogenesis: insights from next-generation sequencing.Human Reproduction Update. 2021;27:1086–97.

Yin X, Pavone ME, Lu Z, Wei J, Kim JJ. Increased Activation of the PI3K/AKT Pathway Compromises Decidualization of Stromal Cells from Endometriosis.The Journal of Clinical Endocrinology \& Metabolism. 2012;97:E35–E43.

Guo J, Gao J, Yu X, Luo H, Xiong X, Huang O. Expression of DJ-1 and mTOR in Eutopic and Ectopic Endometria of Patients with Endometriosis and Adenomyosis.Gynecologic and Obstetric Investigation. 2015;79:195–200.

Madanes D, Bilotas MA, Bastón JI, Singla JJ, Meresman GF, Barañao RI et al. PI3K/AKT pathway is altered in the endometriosis patient’s endometrium and presents differences according to severity stage. Gynecol Endocrinol. 2020;36:436–40.

Janku F, Yap TA, Meric-Bernstam F. Targeting the PI3K pathway in cancer: are we making headway?Nature Reviews Clinical Oncology. 2018;15:273–91.

Méar L, Com E, Fathallah K, Guillot L, Lavigne R, Guével B et al. The Eutopic Endometrium Proteome in Endometriosis Reveals Candidate Markers and Molecular Mechanisms of Physiopathology.Diagnostics. 2022;12:419.

Tuluhong D, Chen T, Wang J, Zeng H, Li H, Dunzhu W, et al. FZD2 promotes TGF-beta-induced epithelial-to-mesenchymal transition in breast cancer via activating notch signaling pathway. Cancer Cell Int. 2021;21(1):199.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gujral TS, Chan M, Peshkin L, Sorger PK, Kirschner MW, MacBeath G. A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis. Cell. 2014;159(4):844–56.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kay N, Huang CY, Shiu LY, Yu YC, Chang Y, Suen JL, et al. The Effects of Anti-TGF-beta1 on epithelial-mesenchymal transition in the pathogenesis of adenomyosis. Reprod Sci. 2020;27(9):1698–706.

Article  CAS  PubMed  Google Scholar 

Bian Y, Chang X, Liao Y, Wang J, Li Y, Wang K, et al. Promotion of epithelial-mesenchymal transition by Frizzled2 is involved in the metastasis of endometrial cancer. Oncol Rep. 2016;36(2):803–10.

Article  CAS  PubMed  Google Scholar 

Calderwood SK, Gong J. Heat shock proteins promote Cancer: it’s a Protection Racket. Trends Biochem Sci. 2016;41(4):311–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alberti G, Vergilio G, Paladino L, Barone R, Cappello F, Conway de Macario E et al. The Chaperone System in Breast Cancer: Roles and Therapeutic Prospects of the Molecular Chaperones Hsp27, Hsp60, Hsp70, and Hsp90.Int J Mol Sci. 2022;23(14).

Li P, Miao C, Liang C, Shao P, Wang Z, Li J. Silencing CAPN2 expression inhibited castration-resistant prostate Cancer cells Proliferation and Invasion via AKT/mTOR Signal Pathway. Biomed Res Int. 2017;2017:2593674.

PubMed  PubMed Central  Google Scholar 

Chen B, Tang J, Guo YS, Li Y, Chen ZN, Jiang JL. Calpains are required for invasive and metastatic potentials of human HCC cells. Cell Biol Int. 2013;37(7):643–52.

Article  CAS  PubMed  Google Scholar 

Quattrone F, Sanchez AM, Pannese M, Hemmerle T, Vigano P, Candiani M, et al. The targeted delivery of interleukin 4 inhibits development of endometriotic lesions in a mouse model. Reprod Sci. 2015;22(9):1143–52.

Article  CAS  PubMed  Google Scholar 

Wang X, Wu P, Zeng C, Zhu J, Zhou Y, Lu Y et al. Long Intergenic Non-Protein Coding RNA 02381 Promotes the Proliferation and Invasion of Ovarian Endometrial Stromal Cells through the miR-27b-3p/CTNNB1 Axis.Genes (Basel). 2022;13(3).

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