An Early, Reversible Cholesterolgenic Etiology of Diet-Induced Insulin Resistance

Akt

AKT serine/threonine kinase

ChIP

Chromatin immunoprecipitation

GFAT

Glutamine:fructose-6-phosphate amidotransferase

GlcNAc

N-acetyl glucosamine

GLUT4

Insulin-responsive glucose transporter

GTT

Glucose tolerance test

HBP

Hexosamine biosynthesis pathway

HMGCR

Hydroxy-3-methylglutaryl CoA reductase

HPRT

Hypoxanthine phosphoribosyl transferase

IPGTT

Intraperitoneal Glucose Tolerance Test

IPITT

Intraperitoneal Insulin Tolerance Test

MRI

Magnetic resonance imaging

Munc18

Mammalian homologue of UNC-18

OGT

O-linked GlcNAc transferase

PDPK1

3-Phosphoinositide dependent protein kinase 1

PI3K

Phosphatidylinositol 3-kinase

PIP2

Phosphatidylinositol 4,5-biphosphate

qPCR

Quantitative polymerase chain reaction

Ra

Endogenous glucose production

RER

Respiratory exchange ratio

SPA

Spontaneous physical activity

VCO2

Carbon dioxide production

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