Allgöwer C, Kretz A-L, von Karstedt S et al (2020) Friend or Foe: S100 Proteins in Cancer. Cancers 12:2037. https://doi.org/10.3390/cancers12082037

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Y, Li J, Xiao J-K et al (2021) The lncRNA NEAT1 promotes the epithelial-mesenchymal transition and metastasis of osteosarcoma cells by sponging miR-483 to upregulate STAT3 expression. Cancer Cell Int 21:90. https://doi.org/10.1186/s12935-021-01780-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheng G, Xue Y-Y, Fang F et al (2021) Promotion of Ros-mediated Bax/Cyt-c apoptosis by polyphyllin II leads to suppress growth and aggression of glioma cells. Transl Cancer Res 10:3894–3905. https://doi.org/10.21037/tcr-21-966

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dong N (2020) Long Noncoding RNA NEAT1 Regulates TGF- β 2-Induced Epithelial-Mesenchymal Transition of Lens Epithelial Cells through the miR-34a/Snail1 and miR-204/Zeb1 Pathways. BioMed Res Int 2020:1–19. https://doi.org/10.1155/2020/8352579

Article  CAS  Google Scholar 

Dong P, Xiong Y, Yue J et al (2018) Long Non-coding RNA NEAT1: A Novel Target for Diagnosis and Therapy in Human Tumors. Front Genet 9:471. https://doi.org/10.3389/fgene.2018.00471

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dongre A, Weinberg RA (2019) New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer. Nat Rev Mol Cell Biol 20:69–84. https://doi.org/10.1038/s41580-018-0080-4

Article  CAS  PubMed  Google Scholar 

Finley LWS (2019) Metabolic signal curbs cancer-cell migration. Nature 571:39–40. https://doi.org/10.1038/d41586-019-01934-9

Article  CAS  PubMed  Google Scholar 

Gershenwald JE, Guy GP (2016) Stemming the Rising Incidence of Melanoma: Calling Prevention to Action. JNCI J Natl Cancer Inst 108: https://doi.org/10.1093/jnci/djv381

Guo Y, Liu Z, Li K et al (2018) Paris Polyphylla -Derived Saponins Inhibit Growth of Bladder Cancer Cells by Inducing Mutant P53 Degradation While Up-Regulating CDKN1A Expression. Curr Urol 11:131–138. https://doi.org/10.1159/000447207

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kalluri R, Weinberg RA (2009) The basics of epithelial-mesenchymal transition. J Clin Invest 119:1420–1428. https://doi.org/10.1172/JCI39104

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Z, Wei D, Yang C et al (2016) Overexpression of long noncoding RNA, NEAT1 promotes cell proliferation, invasion and migration in endometrial endometrioid adenocarcinoma. Biomed Pharmacother 84:244–251. https://doi.org/10.1016/j.biopha.2016.09.008

Article  CAS  PubMed  Google Scholar 

Li K, Yao T, Zhang Y et al (2021) NEAT1 as a competing endogenous RNA in tumorigenesis of various cancers: Role, mechanism and therapeutic potential. Int J Biol Sci 17:3428–3440. https://doi.org/10.7150/ijbs.62728

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin K, Baritaki S, Militello L et al (2010) The Role of B-RAF Mutations in Melanoma and the Induction of EMT via Dysregulation of the NF- B/Snail/RKIP/PTEN Circuit. Genes Cancer 1:409–420. https://doi.org/10.1177/1947601910373795

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luan L, Hu Q, Wang Y et al (2021) Knockdown of lncRNA NEAT1 expression inhibits cell migration, invasion and EMT by regulating the miR-24-3p/LRG1 axis in retinoblastoma cells. Exp Ther Med 21:367. https://doi.org/10.3892/etm.2021.9798

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nakamura M, Tokura Y (2011) Epithelial–mesenchymal transition in the skin. J Dermatol Sci 61:7–13. https://doi.org/10.1016/j.jdermsci.2010.11.015

Article  CAS  PubMed  Google Scholar 

Niu W, Xu L, Li J et al (2020) Polyphyllin II inhibits human bladder cancer migration and invasion by regulating EMT-associated factors and MMPs. Oncol Lett 20:2928–2936. https://doi.org/10.3892/ol.2020.11839

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pastushenko I, Blanpain C (2019) EMT Transition States during Tumor Progression and Metastasis. Trends Cell Biol 29:212–226. https://doi.org/10.1016/j.tcb.2018.12.001

Article  CAS  PubMed  Google Scholar 

Pedri D, Karras P, Landeloos E et al (2022) Epithelial-to-mesenchymal-like transition events in melanoma. FEBS J 289:1352–1368. https://doi.org/10.1111/febs.16021

Article  CAS  PubMed  Google Scholar 

Qin X-J, Ni W, Chen C-X, Liu H-Y (2018) Seeing the light: Shifting from wild rhizomes to extraction of active ingredients from above-ground parts of Paris polyphylla var. yunnanensis. J Ethnopharmacol 224:134–139. https://doi.org/10.1016/j.jep.2018.05.028

Article  CAS  PubMed  Google Scholar 

Ribatti D, Tamma R, Annese T (2020) Epithelial-Mesenchymal Transition in Cancer: A Historical Overview. Transl Oncol 13:100773. https://doi.org/10.1016/j.tranon.2020.100773

Article  PubMed  PubMed Central  Google Scholar 

Shen S, Xu Z, Feng S et al (2018) Structural elucidation and antiaging activity of polysaccharide from Paris polyphylla leaves. Int J Biol Macromol 107:1613–1619. https://doi.org/10.1016/j.ijbiomac.2017.10.026

Article  CAS  PubMed  Google Scholar 

Sinha S, Singh SK, Jangde N et al (2021) p32 promotes melanoma progression and metastasis by targeting EMT markers, Akt/PKB pathway, and tumor microenvironment. Cell Death Dis 12:1012. https://doi.org/10.1038/s41419-021-04311-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stemmler MP, Eccles RL, Brabletz S, Brabletz T (2019) Non-redundant functions of EMT transcription factors. Nat Cell Biol 21:102–112. https://doi.org/10.1038/s41556-018-0196-y

Article  CAS  PubMed  Google Scholar 

Sung H, Ferlay J, Siegel RL et al (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin 71:209–249. https://doi.org/10.3322/caac.21660

Article  PubMed  Google Scholar 

Turner N, Ware O, Bosenberg M (2018) Genetics of metastasis: melanoma and other cancers. Clin Exp Metastasis 35:379–391. https://doi.org/10.1007/s10585-018-9893-y

Article  CAS  PubMed  Google Scholar 

Wang Y-H, Shi M, Niu H-M et al (2018) Substituting one Paris for another? In vitro cytotoxic and in vivo antitumor activities of Paris forrestii, a substitute of Paris polyphylla var. yunnanensis. J Ethnopharmacol 218:45–50. https://doi.org/10.1016/j.jep.2018.02.022

Article  CAS  PubMed  Google Scholar 

Wang SJ, Li WW, Wen CJ, Diao YL, Zhao TL (2020) MicroRNA‑214 promotes the EMT process in melanoma by downregulating CADM1 expression. Mol Med Rep 22(5):3795–3803. https://doi.org/10.3892/mmr.2020.11446

Xia Y, Zhou Y, Han H et al (2019) lncRNA NEAT1 facilitates melanoma cell proliferation, migration, and invasion via regulating miR-495-3p and E2F3. J Cell Physiol 234:19592–19601. https://doi.org/10.1002/jcp.28559

Article  CAS  PubMed  Google Scholar 

Yang J, Antin P, Berx G et al (2020) Guidelines and definitions for research on epithelial–mesenchymal transition. Nat Rev Mol Cell Biol 21:341–352. https://doi.org/10.1038/s41580-020-0237-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang J, Wang P, Cui Y (2021) Long noncoding RNA NEAT1 inhibits the acetylation of PTEN through the miR-524–5p /HDAC1 axis to promote the proliferation and invasion of laryngeal cancer cells. Aging 13:24850–24865. https://doi.org/10.18632/aging.203719

Article  CAS  PubMed  PubMed Central  Google Scholar