Liquid-liquid phase separation: Galectin-3 in nuclear speckles and ribonucleoprotein complexes

Keywords

Intrinsically disordered domains

Liquid phase condensation

Membrane-less organelles

nuclear bodies

AbbreviationsCRD

carbohydrate recognition domain

DSC

differential scanning calorimetry

GST

glutathione S-transferase

hnRNP

heterogeneous nuclear ribonucleoprotein complex

IDR

intrinsically disordered region

LLPS

liquid-liquid phase separation

NOESY

nuclear Overhauser effect spectroscopy

NTD

N-terminal domain of galectin-3

PML

promyelocytic leukemia body

PONDR

Predictor of Naturally Disordered Regions

PSF

polypyrimidine tract binding protein-associated splicing factor

SMN

Survival of Motor Neuron protein

snRNP

small nuclear ribonucleoprotein complex

SR

Ser-, Arg-rich family of splicing factors

TFII-I

general transcription factor-I for RNA polymerase II

Data availability

This is a review article; all the data have been published and cited.

© 2023 The Authors. Published by Elsevier Inc.

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