Frösen, J. & Joutel, A. Smooth muscle cells of intracranial vessels: from development to disease. Cardiovasc. Res. 114, 501–512 (2018).

Article  PubMed  Google Scholar 

Kooi, E. M. W. & Richter, A. E. Cerebral autoregulation in sick infants: current insights. Clin. Perinatol. 47, 449–467 (2020).

Article  PubMed  Google Scholar 

Tan, C. O. Defining the characteristic relationship between arterial pressure and cerebral flow. J. Appl. Physiol. (1985) 113, 1194–1200 (2012).

Article  PubMed  Google Scholar 

Willie, C. K., Tzeng, Y. C., Fisher, J. A. & Ainslie, P. N. Integrative regulation of human brain blood flow. J. Physiol. 592, 841–859 (2014).

Article  CAS  PubMed Central  PubMed  Google Scholar 

Pierce, W. J. & Harder, D. R. In Neurophysiological Basis of Cerebral Blood Flow Control an Introduction (eds Mraovitch, S. & Sercombe, R.) 153–158 (John Libbey, 1996).

Lindauer, U., Vogt, J., Schuh-Hofer, S., Dreier, J. P. & Dirnagl, U. Cerebrovascular vasodilation to extraluminal acidosis occurs via combined activation of ATP-sensitive and Ca2+-activated potassium channels. J. Cereb. Blood Flow. Metab. 23, 1227–1238 (2003).

Article  CAS  PubMed  Google Scholar 

Vutskits, L. Cerebral blood flow in the neonate. Paediatr. Anaesth. 24, 22–29 (2014).

Article  PubMed  Google Scholar 

Kaiser, J. R., Gauss, C. H. & Williams, D. K. The effects of hypercapnia on cerebral autoregulation in ventilated very low birth weight infants. Pediatr. Res. 58, 931–935 (2005).

Article  PubMed Central  PubMed  Google Scholar 

Pryds, O., Greisen, G. & Friis-Hansen, B. Compensatory increase of CBF in preterm infants during hypoglycaemia. Acta Paediatr. Scand. 77, 632–637 (1988).

Article  CAS  PubMed  Google Scholar 

Skov, L. & Pryds, O. Capillary recruitment for preservation of cerebral glucose influx in hypoglycemic, preterm newborns: evidence for a glucose sensor? Pediatrics 90, 193–195 (1992).

Article  CAS  PubMed  Google Scholar 

Mattersberger, C., Schmölzer, G. M., Urlesberger, B. & Pichler, G. Blood glucose and lactate levels and cerebral oxygenation in preterm and term neonates-a systematic qualitative review of the literature. Front. Pediatr. 8, 361 (2020).

Article  PubMed Central  PubMed  Google Scholar 

von Siebenthal, K. et al. Variability of cerebral hemoglobin concentration in very preterm infants during the first 6 h of life. Adv. Exp. Med. Biol. 566, 91–97 (2005).

Article  Google Scholar 

Zhang, G., Cai, S. & Li, J. Hyperglycaemia is negatively associated with systemic and cerebral oxygen transport in neonates after the norwood procedure. Cardiol. Young. 22, 49–56 (2012).

Article  PubMed  Google Scholar 

Matterberger, C. et al. Blood glucose and cerebral tissue oxygenation immediately after birth – an observational study. J. Pediatr. 200, 19–23 (2018).

Article  CAS  PubMed  Google Scholar 

Goadsby, P. J. Autonomic nervous system control of the cerebral circulation. Handb. Clin. Neurol. 117, 193–201 (2013).

Article  PubMed  Google Scholar 

Pryds, O. Control of cerebral circulation in the high-risk neonate. Ann. Neurol. 30, 321–329 (1991).

Article  CAS  PubMed  Google Scholar 

Toda, N., Shimizu, I., Okamura, T. & Miyazaki, M. Age-dependent change in the response of isolated beagle cerebral arteries to vasoactive agents. J. Cardiovasc. Pharm. 8, 681–688 (1986).

CAS  Google Scholar 

Bevan, R. et al. Responsiveness of human infant cerebral arteries to sympathetic nerve stimulation and vasoactive agents. Pediatr. Res. 44, 730–739 (1998).

Article  CAS  PubMed  Google Scholar 

Hendrikx, D. et al. Measurement of neurovascular coupling in neonates. Front. Physiol. 10, 65 (2019).

Article  PubMed Central  PubMed  Google Scholar 

Sakatani, K., Chen, S., Lichty, W., Zuo, H. & Wang, Y. P. Cerebral blood oxygenation changes induced by auditory stimulation in newborn infants measured by near infrared spectroscopy. Early Hum. Dev. 55, 229–236 (1999).

Article  CAS  PubMed  Google Scholar 

Kusaka, T. et al. Noninvasive optical imaging in the visual cortex in young infants. Hum. Brain Mapp. 22, 122–132 (2004).

Article  PubMed Central  PubMed  Google Scholar 

Meek, J. H. et al. Regional hemodynamic responses to visual stimulation in awake infants. Pediatr. Res. 43, 840–843 (1998).

Article  CAS  PubMed  Google Scholar 

Karen, T. et al. Hemodynamic response to visual stimulation in newborn infants using functional near-infrared spectroscopy. Hum. Brain Mapp. 29, 453–460 (2008).

Article  PubMed  Google Scholar 

Zaramella, P. et al. Brain auditory activation measured by near-infrared spectroscopy (NIRS) in neonates. Pediatr. Res. 49, 213–219 (2001).

Article  CAS  PubMed  Google Scholar 

Kozberg, M. & Hillman, E. Neurovascular coupling and energy metabolism in the developing brain. Prog. Brain Res. 225, 213–242 (2016).

Article  CAS  PubMed Central  PubMed  Google Scholar 

Inocencio, I. M. et al. Cerebral haemodynamic response to somatosensory stimulation in preterm lambs and 7-10-day old lambs born at term: direct synchrotron microangiography assessment. J. Cereb. Blood Flow. Metab. 42, 315–328 (2022).

Article  CAS  PubMed  Google Scholar 

Fantini, S., Sassaroli, A., Tgavalekos, K. T. & Kornbluth, J. Cerebral blood flow and autoregulation: current measurement techniques and prospects for noninvasive optical methods. Neurophotonics 3, 031411 (2016).

Article  PubMed Central  PubMed  Google Scholar 

Weindling, A. M. & Kissack, C. M. Blood pressure and tissue oxygenation in the newborn baby at risk of brain damage. Biol. Neonate 79, 241–245 (2001).

Article  CAS  PubMed  Google Scholar 

Greisen, G. Autoregulation of cerebral blood flow in newborn babies. Early Hum. Dev. 81, 423–428 (2005).

Article  PubMed  Google Scholar 

Bellapart, J. & Fraser, J. F. Transcranial Doppler assessment of cerebral autoregulation. Ultrasound Med. Biol. 35, 883–893 (2009).

Article  PubMed  Google Scholar 

Boylan, G. B., Young, K., Panerai, R. B., Rennie, J. M. & Evans, D. H. Dynamic cerebral autoregulation in sick newborn infants. Pediatr. Res. 48, 12–17 (2000).

Article  CAS  PubMed  Google Scholar 

Boylan, G. B. et al. Cerebral blood flow velocity during neonatal seizures. Arch. Dis. Child Fetal Neonatal Ed. 80, F105–F110 (1999).

Article  CAS  PubMed Central  PubMed  Google Scholar 

Panerai, R. B., Kelsall, A. W., Rennie, J. M. & Evans, D. H. Cerebral autoregulation dynamics in premature newborns. Stroke 26, 74–80 (1995).

Article  CAS  PubMed  Google Scholar 

Pellicer, A. & Bravo, M. C. Near-infrared spectroscopy: a methodology-focused review. Semin. Fetal Neonatal Med. 16, 42–49 (2011).

Article  PubMed  Google Scholar 

Wyatt, J. S. et al. Quantitation of cerebral blood volume in human infants by near-infrared spectroscopy. J. Appl. Physiol. (1985) 68, 1086–1091 (1990).

Article  CAS  PubMed  Google Scholar 

Lee, J. K. et al. Cerebrovascular reactivity measured by near-infrared spectroscopy. Stroke 40, 1820–1826 (2009).

Article  PubMed  Google Scholar 

Pryds, O., Greisen, G., Skov, L. L. & Friis-Hansen, B. Carbon dioxide-related changes in cerebral blood volume and cerebral blood flow in mechanically ventilated preterm neonates: comparison of near infrared spectrophotometry and 133Xenon clearance. Pediatr. Res. 27, 445–449 (1990).

Article  CAS  PubMed  Google Scholar 

Brew, N., Walker, D. & Wong, F. Y. Cerebral vascular regulation and brain injury in preterm infants. Am. J. Physiol. Regul. Integr. Comp. Physiol. 306, R773–R786 (2014).

Article  CAS  PubMed  Google Scholar 

Zhang, R., Zuckerman, J. H., Giller, C. A. & Levine, B. D. Transfer function analysis of dynamic cerebral autoregulation in humans. Am. J. Physiol. 274, H233–H241 (1998).

CAS  PubMed  Google Scholar 

Claassen, J. A., Meel-van den Abeelen, A. S., Simpson, D. M. & Panerai, R. B., International Cerebral Autoregulation Research Network (CARNet). Transfer function analysis of dynamic cerebral autoregulation: a white paper from the International Cerebral Autoregulation Research Network. J. Cereb. Blood Flow. Metab. 36, 665–680 (2016).

Article  PubMed Central  PubMed