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Luo Z, Xu W, Ma S, et al. Moderate Autophagy Inhibits Vascular Smooth Muscle Cell Senescence to Stabilize Progressed Atherosclerotic Plaque via the mTORC1/ULK1/ATG13 Signal Pathway. Oxid Med Cell Longev 2017; 2017: 3018190.
[11] Chen Q, Haddad GG. Role of trehalose phosphate synthase and trehalose during hypoxia: from flies to mammals. J Exp Biol 2004; 207: 3125−3129. doi: 10.1242/jeb.01133 [12] Chen X, Li M, Li L, Xu S, et al. Trehalose, sucrose and raffinose are novel activators of autophagy in human keratinocytes through an mTOR-independent pathway. Sci Rep 2016; 6: 28423. doi: 10.1038/srep28423 [13] Yaribeygi H, Yaribeygi A, Sathyapalan T, Sahebkar A. Molecular mechanisms of trehalose in modulating glucose homeostasis in diabetes. Diabetes Metab Syndr 2019; 13: 2214−2218. doi: 10.1016/j.dsx.2019.05.023 [14] Pyo R, Lee JK, Shipley JM, et al. Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms. J Clin Invest 2000; 105: 1641−1649. doi: 10.1172/JCI8931 [15] Li G, Qin L, Wang L, et al. Inhibition of the mTOR pathway in abdominal aortic aneurysm: implications of smooth muscle cell contractile phenotype, inflammation, and aneurysm expansion. Am J Physiol Heart Circ Physiol 2017; 312: H1110−H1119. doi: 10.1152/ajpheart.00677.2016 [16] Busch A, Chernogubova E, Jin H, et al. Four surgical modifications to the classic elastase perfusion aneurysm model enable haemodynamic alterations and extended elastase perfusion. Eur J Vasc Endovasc Surg 2018; 56: 102−109. doi: 10.1016/j.ejvs.2018.03.018 [17] Henderson EL, Geng YJ, Sukhova GK, et al. Death of smooth muscle cells and expression of mediators of apoptosis by T lymphocytes in human abdominal aortic aneurysms. Circulation 1999; 99: 96−104. doi: 10.1161/01.CIR.99.1.96 [18] Clement M, Chappell J, Raffort J, et al. Vascular smooth muscle cell plasticity and autophagy in dissecting aortic aneurysms. Arterioscler Thromb Vasc Biol 2019; 39: 1149−1159. doi: 10.1161/ATVBAHA.118.311727 [19] Wang L, Liu S, Pan B, et al. The role of autophagy in abdominal aortic aneurysm: protective but dysfunctional. Cell Cycle 2020; 19: 2749−2759. doi: 10.1080/15384101.2020.1823731 [20] Zheng YH, Tian C, Meng Y, et al. Osteopontin stimulates autophagy via integrin/CD44 and p38 MAPK signaling pathways in vascular smooth muscle cells. J Cell Physiol 2012; 227: 127−135. doi: 10.1002/jcp.22709 [21] Lawrence DM, Singh RS, Franklin DP, et al. Rapamycin suppresses experimental aortic aneurysm growth. J Vasc Surg 2004; 40: 334−338. doi: 10.1016/j.jvs.2004.05.020 [22] Wang Z, Guo J, Han X, et al. Metformin represses the pathophysiology of AAA by suppressing the activation of PI3K/AKT/mTOR/autophagy pathway in ApoE(-/-) mice. Cell Biosci 2019; 9: 68. doi: 10.1186/s13578-019-0332-9 [23] Yoon YS, Cho ED, Jung Ahn W, et al. Is trehalose an autophagic inducer? Unraveling the roles of non-reducing disaccharides on autophagic flux and alpha-synuclein aggregation. Cell Death Dis 2017; 8: e3091. doi: 10.1038/cddis.2017.501 [24] Echigo R, Shimohata N, Karatsu K, et al. Trehalose treatment suppresses inflammation, oxidative stress, and vasospasm induced by experimental subarachnoid hemorrhage. J Transl Med 2012; 10: 80. doi: 10.1186/1479-5876-10-80 [25] Sarkar S, Davies JE, Huang Z, et al. Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. J Biol Chem 2007; 282: 5641−5652. doi: 10.1074/jbc.M609532200 [26] Zhang X, Chen S, Song L, et al. MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis. Autophagy 2014; 10: 588−602. doi: 10.4161/auto.27710 [27]DeBosch BJ, Heitmeier MR, Mayer AL, et al. Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis. Sci Signal 2016; 9: ra21.
[28] Sciarretta S, Yee D, Nagarajan N, et al. Trehalose-induced activation of autophagy improves cardiac remodeling after myocardial infarction. J Am Coll Cardiol 2018; 71: 1999−2010. doi: 10.1016/j.jacc.2018.02.066 [29] Sergin I, Evans TD, Zhang X, et al. Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis. Nat Commun 2017; 8: 15750. doi: 10.1038/ncomms15750
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