Anxiety Sensitivity and Intolerance of Uncertainty: Transdiagnostic Risk Factors for Anxiety as Targets to Reduce Risk of Suicide

Hedegaard H. Suicide Mortality in the United States, 1999–2019. National Center for Health Statistics. 2021. https://doi.org/10.15620/cdc:101761.

Stone DM, Jones CM, Mack KA. Changes in suicide rates — United States, 2018–2019. Morb Mortal Wkly Rep. 2021;70(8):261–8. https://doi.org/10.15585/mmwr.mm7008a1.

Article  Google Scholar 

Ilgen MA, Bohnert ASB, Ignacio RV, et al. Psychiatric diagnoses and risk of suicide in veterans. Arch Gen Psychiatry. 2010;67(11):1152. https://doi.org/10.1001/archgenpsychiatry.2010.129.

Article  PubMed  Google Scholar 

Khan A, Leventhal RM, Khan S, Brown WA. Suicide risk in patients with anxiety disorders: a meta-analysis of the FDA database. J Affect Disord. 2002;68(2):183–90. https://doi.org/10.1016/S0165-0327(01)00354-8.

Article  PubMed  Google Scholar 

Sareen J, Cox BJ, Afifi TO, et al. Anxiety disorders and risk for suicidal ideation and suicide attempts: a population-based longitudinal study of adults. Arch Gen Psychiatry. 2005;62(11):1249–57. https://doi.org/10.1001/archpsyc.62.11.1249.

Article  PubMed  Google Scholar 

Sareen J. Anxiety disorders and risk for suicide: why such controversy? Depress Anxiety. 2011;28(11):941–5. https://doi.org/10.1002/da.20906.

Article  PubMed  Google Scholar 

• Franklin JC, Ribeiro JD, Fox KR, et al. Risk factors for suicidal thoughts and behaviors: a meta-analysis of 50 years of research. Psychol Bull. 2017;143(2):187–232. https://doi.org/10.1037/bul0000084This meta-regression article explores clusters of risk factors as predictors of suicidal thoughts and behavior longitudinally. Anxiety is grouped in the internalizing disorders cluster. Across studies, internalizing disorders as a category was a small but significant predictor of suicidal ideation, suicide attempt, and suicide death.

• Moitra M, Santomauro D, Degenhardt L, et al. Estimating the risk of suicide associated with mental disorders: a systematic review and meta-regression analysis. J Psychiatr Res. 2021;137:242–249. https://doi.org/10.1016/j.jpsychires.2021.02.053This meta-regression examined mental health disorders as longitudinal predictors of suicide risk in studies published between 2010 and 2019. Anxiety disorders demonstrated a significant risk ratio association with suicide risk.

• De La Vega D, Giner L, Courtet P. Suicidality in subjects with anxiety or obsessive-compulsive and related disorders: recent advances. Curr Psychiatry Rep. 2018;20(4):26. https://doi.org/10.1007/s11920-018-0885-zThis review article presented on recent research demonstrating that anxiety disorders increase suicide risk. The authors highlight that more research is needed to determine the role of comorbidities in explaining the association between anxiety disorders and suicide.

American Psychiatric Association. Diagnostic and stastical manual. 5th ed. American Psychiatric Association.

Bomyea J, Lang AJ, Golinelli D, et al. Trauma exposure in anxious primary care patients. J Psychopathol Behav Assess. 2013;35(2):254–63. https://doi.org/10.1007/s10862-012-9327-0.

Article  CAS  PubMed  Google Scholar 

Foldes-Busque G, Fleet R, Poitras J, Chauny JM, Diodati JG, Marchand A. Suicidality and panic in emergency department patients with unexplained chest pain. Gen Hosp Psychiatry. 2012;34(2):178–84. https://doi.org/10.1016/j.genhosppsych.2011.12.005.

Article  PubMed  Google Scholar 

Huang MF, Yen CF, Lung FW. Moderators and mediators among panic, agoraphobia symptoms, and suicidal ideation in patients with panic disorder. Compr Psychiatry. 2010;51(3):243–9. https://doi.org/10.1016/j.comppsych.2009.07.005.

Article  PubMed  Google Scholar 

Lim SW, Ko EM, Shin DW, Shin YC, Oh KS. Clinical symptoms associated with suicidality in patients with panic disorder. Psychopathology. 2015;48(3):137–44. https://doi.org/10.1159/000368904.

Article  PubMed  Google Scholar 

Gilmour H. Threshold and subthreshold Generalized Anxiety Disorder (GAD) and suicide ideation. Health Rep. 2016;27(82):11.

PubMed  Google Scholar 

Bryan CJ, Rudd MD, Wertenberger E. Reasons for suicide attempts in a clinical sample of active duty soldiers. J Affect Disord. 2013;144(1–2):148–52. https://doi.org/10.1016/j.jad.2012.06.030.

Article  PubMed  Google Scholar 

Bryan CJ, Rudd MD. The importance of temporal dynamics in the transition from suicidal thought to behavior. Clin Psychol Sci Pract. 2016;23(1):21–5. https://doi.org/10.1111/cpsp.12135.

Article  Google Scholar 

Shneidman ES. Commentary: Suicide as psychache. J Nerv Ment Dis: Published online; 1993.

Google Scholar 

• Bryan CJ, Rudd MD, Wertenberger E. Individual and environmental contingencies associated with multiple suicide attempts among U.S. military personnel. Psychiatry Res. 2016;242:88–93. https://doi.org/10.1016/j.psychres.2016.05.028This empirical article presented data from interviews conducted with 134 active duty military servicemembers immediately after a suicide attempt who had (n = 65) and had not (n = 69) attempted suicide again. Results indicated that servicemembers who attempted suicide again were more likely to be young during their first attempt, to not be hospitalized or have received treatment after the first attempt, and who experienced emotional and psychological relief immediately after their first attempt.

Bryan CJ, May AM, Harris J. Examining emotion relief motives as a facilitator of the transition from suicidal thought to first suicide attempt among active duty soldiers. Psychol Serv. 2019;16(2):293–301. https://doi.org/10.1037/ser0000234.

Article  PubMed  Google Scholar 

Grove JL, Smith TW, Carlson SE, et al. Prospective association between suicide cognitions and emotional responses to a laboratory stressor: the mediating role of nightly subjective sleep quality. J Affect Disord. 2020;265:77–84. https://doi.org/10.1016/j.jad.2020.01.060.

Article  PubMed  Google Scholar 

Allan NP, Norr AM, Boffa JW, Durmaz D, Raines AM, Schmidt NB. Examining the unique relations between anxiety sensitivity factors and suicidal ideation and past suicide attempts. Psychiatry Res. 2015;228(3):441–7. https://doi.org/10.1016/j.psychres.2015.05.066.

Article  PubMed  Google Scholar 

Nock MK, Hwang I, Sampson NA, Kessler RC. Mental disorders, comorbidity and suicidal behavior: results from the National Comorbidity Survey Replication. Mol Psychiatry. 2010;15(8):868–76. https://doi.org/10.1038/mp.2009.29.

Article  CAS  PubMed  Google Scholar 

• Klonsky ED, Saffer BY, Bryan CJ. Ideation-to-action theories of suicide: a conceptual and empirical update. Curr Opin Psychol. 2018;22:38–43. https://doi.org/10.1016/j.copsyc.2017.07.020This article reviews ideation-to-action theories of suicide. Similarities and differences between these models are discussed.

Klonsky ED, Dixon-Luinenburg T, May AM. The critical distinction between suicidal ideation and suicide attempts. World Psychiatry. 2021;20(3):439–41. https://doi.org/10.1002/wps.20909.

Article  PubMed  PubMed Central  Google Scholar 

Rudd MD. Fluid vulnerability theory: a cognitive approach to understanding the process of acute and chronic suicide risk. In: Ellis TE, editor. Cognition and suicide: theory, research, and therapy. American Psychological Association. 2006;355–368.

Berenbaum H. Classification and psychopathology research. J Abnorm Psychol. 2013;122(3):894–901. https://doi.org/10.1037/a0033096.

Article  PubMed  Google Scholar 

Lilienfeld SO. The Research Domain Criteria (RDoC): an analysis of methodological and conceptual challenges. Behav Res Ther. 2014;62:129–39. https://doi.org/10.1016/j.brat.2014.07.019.

Article  PubMed  Google Scholar 

Patrick CJ, Hajcak G. RDoC: translating promise into progress: RDoC: translating promise into progress. Psychophysiology. 2016;53(3):415–24. https://doi.org/10.1111/psyp.12612.

Article  PubMed  Google Scholar 

Cuthbert BN, Kozak MJ. Constructing constructs for psychopathology: the NIMH research domain criteria. J Abnorm Psychol. 2013;122(3):928–37. https://doi.org/10.1037/a0034028.

Article  PubMed  Google Scholar 

Insel T, Cuthbert B, Garvey M, et al. Research Domain Criteria (RDoC): toward a new classification framework for research on mental disorders. Am J Psychiatry. 2010;167(7):748–51. https://doi.org/10.1176/appi.ajp.2010.09091379.

Article  PubMed  Google Scholar 

Kozak MJ, Cuthbert BN. The NIMH research domain criteria initiative: background, issues, and pragmatics: NIMH Research Domain Criteria initiative. Psychophysiology. 2016;53(3):286–97. https://doi.org/10.1111/psyp.12518.

Article  PubMed  Google Scholar 

• Glenn CR, Kleiman EM, Cha CB, Deming CA, Franklin JC, Nock MK. Understanding suicide risk within the Research Domain Criteria (RDoC) framework: a meta-analytic review. Depress Anxiety. 2018;35(1):65–88. https://doi.org/10.1002/da.22686This meta-analytic review examines research exploring risk factors for suicide through the RDoC lens.

• Stewart JG, Polanco-Roman L, Duarte CS, Auerbach RP. Neurocognitive processes implicated in adolescent suicidal thoughts and behaviors: applying an RDoC framework for conceptualizing risk. Curr Behav Neurosci Rep. 2019;6(4):188–196. https://doi.org/10.1007/s40473-019-00194-1This review article explores the RDoC criteria as a framework for neurocognitive deficits in adolescents at-risk for suicide.

Barlow DH. Unraveling the mysteries of anxiety and its disorders from the perspective of emotion theory. Am Psychol. 2000;55(11):1247.

Article  CAS  PubMed  Google Scholar 

Davis M, Walker DL, Miles L, Grillon C. Phasic vs sustained fear in rats and humans: role of the extended amygdala in fear vs anxiety. Neuropsychopharmacology. 2010;35(1):105–35. https://doi.org/10.1038/npp.2009.109.

Article  PubMed  Google Scholar 

Grillon C, Levenson J, Pine DS. A single dose of the selective serotonin reuptake inhibitor citalopram exacerbates anxiety in humans: a fear-potentiated startle study. Neuropsychopharmacology. 2007;32(1):225–31. https://doi.org/10.1038/sj.npp.1301204.

Article  CAS  PubMed  Google Scholar 

Yaseen ZS, Chartrand H, Mojtabai R, Bolton J, Galynker II. Fear of dying in panic attacks predicts suicide attempt in comorbid depressive illness: prospective evidence from the national epidemiological survey on alcohol and related conditions. Depress Anxiety. 2013;30(10):930–9. https://doi.org/10.1002/da.22039.

Article  PubMed  Google Scholar 

Poletti S, Radaelli D, Cucchi M, et al. Neural correlates of anxiety sensitivity in panic disorder: a functional magnetic resonance imaging study. Psychiatry Res Neuroimaging. 2015;233(2):95–101. https://doi.org/10.1016/j.pscychresns.2015.05.013.

Article  Google Scholar 

Yang Y, Lueken U, Wittmann A, et al. Neural correlates of individual differences in anxiety sensitivity: an fMRI study using semantic priming. Soc Cogn Affect Neurosci. 2016;11(8):1245–54. https://doi.org/10.1093/scan/nsw024.

Article  PubMed  PubMed Central  Google Scholar 

Shankman SA, Gorka SM, Nelson BD, Fitzgerald DA, Phan KL, O’Daly O. Anterior insula responds to temporally unpredictable aversiveness: an fMRI study. NeuroReport. 2014;25(8):596–600. https://doi.org/10.1097/WNR.0000000000000144.

Article  PubMed  PubMed Central  Google Scholar 

Simmons A, Matthews SC, Paulus MP, Stein MB. Intolerance of uncertainty correlates with insula activation during affective ambiguity. Neurosci Lett. 2008;430(2):92–7. https://doi.org/10.1016/j.neulet.2007.10.030.

Article  CAS  PubMed  Google Scholar 

Ballard ED, Farmer CA, Gerner J, Bloomfield-Clagett B, Park LT, Zarate CA. Prospective association of psychological pain and hopelessness with suicidal thoughts. J Affect Disord. 2022;308:243–8. https://doi.org/10.1016/j.jad.2022.04.033.

Article  PubMed  Google Scholar 

Gilbert K, Perino MT, Myers MJ, Sylvester CM. Overcontrol and neural response to errors in pediatric anxiety disorders. J Anxiety Disord. 2020;72:102224. https://doi.org/10.1016/j.janxdis.2020.102224

• Schmaal L, van Harmelen AL, Chatzi V, et al. Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies. Mol Psychiatry. 2020;25(2):408–427. https://doi.org/10.1038/s41380-019-0587-xThis review article provided a synthesis of findings from imaging studies on suicidal thoughts and behaviors. Neural regions that account for emotion and impulse regulation as well as connections between these regions appear to be most commonly supported.

Reiss S, Peterson RA, Gursky DM, McNally RJ. Anxiety sensitivity, anxiety frequency and the prediction of fearfulness. Behav Res Ther. 1986;24(1):1–8. https://doi.org/10.1016/0005-7967(86)90143-9.

Article  CAS  PubMed  Google Scholar 

Allan NP, Capron DW, Raines AM, Schmidt NB. Unique relations among anxiety sensitivity factors and anxiety, depression, and suicidal ideation. J Anxiety Disord. 2014;28(2):266–75. https://doi.org/10.1016/j.janxdis.2013.12.004.

Article  PubMed  Google Scholar 

Taylor S, Zvolensky MJ, Cox BJ, et al. Robust dimensions of anxiety sensitivity: development and initial validation of the anxiety sensitivity index—3. Psychol Assess. 2014;19:176–88.

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