Alteration of the tumor microenvironment by pharmacological inhibition of EZH2 in hepatocellular carcinoma

Keywords

Hepatocellular carcinoma

Enhancer of zeste homolog 2

Tumor microenvironment

UNC1999

Myeloid-derived suppressor cells

Chemokines

AbbreviationsEZH2

enhancer of zeste homolog 2

HCC

hepatocellular carcinoma

H3K27me3

trimethylation of lysine 27 of histone H3

MDSCs

myeloid-derived suppressor cells

NOD/SCID

nonobese diabetic/severe combined immunodeficient

RT-PCR

reverse transcription-polymerase chain reaction

TAMs

tumor-associated macrophages

TILs

tumor-infiltrating lymphocytes

TME

tumor microenvironment

TNF-α

tumor necrosis factor-α

Data availability

Data will be made available on request.

© 2023 Elsevier B.V. All rights reserved.

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