Agarwal A, Mulgund A, Hamada A, Chyatte MR (2015) A unique view on male infertility around the globe. Reprod Biol Endocrinol 13:1–9. https://doi.org/10.1186/s12958-015-0032-1

Article  Google Scholar 

Akbari A, Pipitone GB, Anvar Z, Jaafarinia M, Ferrari M, Carrera P, Totonchi M (2019) ADCY10 frameshift variant leading to severe recessive asthenozoospermia and segregating with absorptive hypercalciuria. Hum Reprod 34:1155–1164. https://doi.org/10.1093/humrep/dez048

Article  CAS  PubMed  Google Scholar 

Arafa M, AlMalki A, AlBadr M, Burjaq H, Majzoub A, AlSaid S, Elbardisi H (2018) ICSI outcome in patients with high DNA fragmentation: Testicular versus ejaculated spermatozoa. Andrologia 50. https://doi.org/10.1111/and.12835

Bahler M, Rhoads A (2002) Calmodulin signaling via the IQ motif. Febs Lett 513:107–113. https://doi.org/10.1016/s0014-5793(01)03239-2

Article  CAS  PubMed  Google Scholar 

Ben KM, Coutton C, Zouari R, Karaouzene T, Rendu J, Bidart M, Yassine S, Pierre V, Delaroche J, Hennebicq S, Grunwald D, Escalier D, Pernet-Gallay K, Jouk PS, Thierry-Mieg N, Toure A, Arnoult C, Ray PF (2014) Mutations in DNAH1, which encodes an inner arm heavy chain dynein, lead to male infertility from multiple morphological abnormalities of the sperm flagella. Am J Hum Genet 94:95–104. https://doi.org/10.1016/j.ajhg.2013.11.017

Article  CAS  Google Scholar 

Cao W, Ijiri TW, Huang AP, Gerton GL (2011) Characterization of a novel tektin member, TEKT5, in mouse sperm. J Androl 32:55–69. https://doi.org/10.2164/jandrol.109.009456

Article  CAS  PubMed  Google Scholar 

Chen CC, Yang JH, Fu SL, Lin WJ, Lin CH (2021) Arginine Methylation of hnRNPK Inhibits the DDX3-hnRNPK Interaction to Play an Anti-Apoptosis Role in Osteosarcoma Cells. Int J Mol Sci. https://doi.org/10.3390/ijms22189764

Article  PubMed  PubMed Central  Google Scholar 

Fang P, Xu W, Li D, Zhao X, Dai J, Wang Z, Yan X, Qin M, Zhang Y, Xu C, Wang L, Qiao Z (2015) A novel acrosomal protein, IQCF1, involved in sperm capacitation and the acrosome reaction. Andrology 3:332–344. https://doi.org/10.1111/andr.296

Article  CAS  PubMed  Google Scholar 

Gao Y, Wu H, Xu Y, Shen Q, Xu C, Geng H, Lv M, Tan Q, Li K, Tang D, Song B, Zhou P, Wei Z, He X, Cao Y (2021) Novel biallelic mutations in SLC26A8 cause severe asthenozoospermia in humans owing to midpiece defects: Insights into a putative dominant genetic disease. Hum Mutat 43:434–443. https://doi.org/10.1002/humu.24322

Article  CAS  PubMed  Google Scholar 

Hagiuda J, Takasaki N, Oya M, Ishikawa H, Narimatsu H (2020) Mutation of GALNTL5 gene identified in patients diagnosed with asthenozoospermia. Hum Fertil (camb) 23:226–233. https://doi.org/10.1080/14647273.2018.1562239

Article  CAS  PubMed  Google Scholar 

Harris TP, Schimenti KJ, Munroe RJ, Schimenti JC, (2014) IQ motif-containing G (Iqcg) is required for mouse spermiogenesis. G3 (Bethesda) https://doi.org/10.1534/g3.113.009563

He X, Li W, Wu H, Lv M, Liu W, Liu C, Zhu F, Li C, Fang Y, Yang C, Cheng H, Zhang J, Tan J, Chen T, Tang D, Song B, Wang X, Zha X, Wang H, Wei Z, Yang S, Saiyin H, Zhou P, Jin L, Wang J, Zhang Z, Zhang F, Cao Y (2019) Novel homozygous CFAP69 mutations in humans and mice cause severe asthenoteratospermia with multiple morphological abnormalities of the sperm flagella. J Med Genet 56:96–103. https://doi.org/10.1136/jmedgenet-2018-105486

Article  CAS  PubMed  Google Scholar 

Hoogewijs D, Ebner B, Germani F, Hoffmann FG, Fabrizius A, Moens L, Burmester T, Dewilde S, Storz JF, Vinogradov SN, Hankeln T (2012) Androglobin: A chimeric globin in metazoans that is preferentially expressed in Mammalian testes. Mol Biol Evol 29:1105–1114. https://doi.org/10.1093/molbev/msr246

Article  CAS  PubMed  Google Scholar 

Houston BJ, Riera-Escamilla A, Wyrwoll MJ, Salas-Huetos A, Xavier MJ, Nagirnaja L, Friedrich C, Conrad DF, Aston KI, Krausz C, Tuttelmann F, O’Bryan MK, Veltman JA, Oud MS (2021) A systematic review of the validated monogenic causes of human male infertility: 2020 update and a discussion of emerging gene-disease relationships. Hum Reprod Update 28:15–29. https://doi.org/10.1093/humupd/dmab030

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang B, Lu YS, Li X, Zhu ZC, Li K, Liu JW, Zheng J, Hu ZL (2014) Androglobin knockdown inhibits growth of glioma cell lines. Int J Clin Exp Pathol 7:2179–2184

PubMed  PubMed Central  Google Scholar 

Joachimiak E, Osinka A, Farahat H, Swiderska B, Sitkiewicz E, Poprzeczko M, Fabczak H, Wloga D (2021) Composition and function of the C1b/C1f region in the ciliary central apparatus. Sci Rep 11:11760. https://doi.org/10.1038/s41598-021-90996-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Keppner A, Correia M, Santambrogio S, Koay TW, Maric D, Osterhof C, Winter DV, Clerc A, Stumpe M, Chalmel F, Dewilde S, Odermatt A, Kressler D, Hankeln T, Wenger RH, Hoogewijs D (2022) Androglobin, a chimeric mammalian globin, is required for male fertility. Elife. https://doi.org/10.7554/eLife.72374

Article  PubMed  PubMed Central  Google Scholar 

Koay TW, Osterhof C, Orlando I, Keppner A, Andre D, Yousefian S, Suarez AM, Correia M, Markworth R, Schodel J, Hankeln T, Hoogewijs D (2021) Androglobin gene expression patterns and FOXJ1-dependent regulation indicate its functional association with ciliogenesis. J Biol Chem. https://doi.org/10.1016/j.jbc.2021.100291

Article  PubMed  PubMed Central  Google Scholar 

Kyjovska ZO, Boisen AM, Jackson P, Wallin H, Vogel U, Hougaard KS (2013) Daily sperm production: application in studies of prenatal exposure to nanoparticles in mice. Reprod Toxicol 36:88–97. https://doi.org/10.1016/j.reprotox.2012.12.005

Article  CAS  PubMed  Google Scholar 

Leaver RB (2016) Male infertility: an overview of causes and treatment options. Br J Nurs 25: S35-S40. https://doi.org/10.12968/bjon.2016.25.18.S35

Li X, Yan X, Wang F, Yang Q, Luo X, Kong J, Ju S (2019) Down-regulated lncRNA SLC25A5-AS1 facilitates cell growth and inhibits apoptosis via miR-19a-3p/PTEN/PI3K/AKT signalling pathway in gastric cancer. J Cell Mol Med 23:2920–2932. https://doi.org/10.1111/jcmm.14200

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li DY, Yang XX, Tu CF, Wang WL, Meng LL, Lu GX, Tan YQ, Zhang QJ, Du J (2021) Sperm flagellar 2 (SPEF2) is essential for sperm flagellar assembly in humans. Asian J Androl 24:359. https://doi.org/10.4103/aja202154

Article  CAS  PubMed Central  Google Scholar 

Liu C, Miyata H, Gao Y, Sha Y, Tang S, Xu Z, Whitfield M, Patrat C, Wu H, Dulioust E, Tian S, Shimada K, Cong J, Noda T, Li H, Morohoshi A, Cazin C, Kherraf ZE, Arnoult C, Jin L, He X, Ray PF, Cao Y, Toure A, Zhang F, Ikawa M (2020) Bi-allelic DNAH8 Variants Lead to Multiple Morphological Abnormalities of the Sperm Flagella and Primary Male Infertility. Am J Hum Genet 107:330–341. https://doi.org/10.1016/j.ajhg.2020.06.004

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lores P, Coutton C, El KE, Stouvenel L, Givelet M, Thomas L, Rode B, Schmitt A, Louis B, Sakheli Z, Chaudhry M, Fernandez-Gonzales A, Mitsialis A, Dacheux D, Wolf JP, Papon JF, Gacon G, Escudier E, Arnoult C, Bonhivers M, Savinov SN, Amselem S, Ray PF, Dulioust E, Toure A (2018) Homozygous missense mutation L673P in adenylate kinase 7 (AK7) leads to primary male infertility and multiple morphological anomalies of the flagella but not to primary ciliary dyskinesia. Hum Mol Genet 27:1196–1211. https://doi.org/10.1093/hmg/ddy034

Article  CAS  PubMed  Google Scholar 

Lu C, Yang D, Lei C, Wang R, Guo T, Luo H (2021) Identification of two novel DNAAF2 variants in two consanguineous families with primary ciliary Dyskinesia. Pharmgenomics Pers Med 14:1415–1423. https://doi.org/10.2147/PGPM.S338981

Article  CAS  PubMed  PubMed Central  Google Scholar 

Manfrevola F, Chioccarelli T, Cobellis G, Fasano S, Ferraro B, Sellitto C, Marella G, Pierantoni R, Chianese R (2020) CircRNA role and circRNA-dependent network (ceRNET) in asthenozoospermia. Front Endocrinol (lausanne) 11:395. https://doi.org/10.3389/fendo.2020.00395

Article  PubMed  Google Scholar 

Matsuoka Y, Miyagawa Y, Tokuhiro K, Kitamura K, Iguchi N, Maekawa M, Takahashi T, Tsujimura A, Matsumiya K, Okuyama A, Nishimune Y, Tanaka H (2008) Isolation and characterization of the spermatid-specific Smrp1 gene encoding a novel manchette protein. Mol Reprod Dev 75:967–975. https://doi.org/10.1002/mrd.20835

Article  CAS  PubMed  Google Scholar 

Miki K, Willis WD, Brown PR, Goulding EH, Fulcher KD, Eddy EM (2002) Targeted disruption of the Akap4 gene causes defects in sperm flagellum and motility. Dev Biol 248:331–342. https://doi.org/10.1006/dbio.2002.0728

Article  CAS  PubMed  Google Scholar 

Okuda H, DeBoer K, O’Connor AE, Merriner DJ, Jamsai D, O’Bryan MK (2017) LRGUK1 is part of a multiprotein complex required for manchette function and male fertility. Faseb J 31:1141–1152. https://doi.org/10.1096/fj.201600909R

Article  CAS  PubMed  Google Scholar 

Platts AE, Dix DJ, Chemes HE, Thompson KE, Goodrich R, Rockett JC, Rawe VY, Quintana S, Diamond MP, Strader LF, Krawetz SA (2007) Success and failure in human spermatogenesis as revealed by teratozoospermic RNAs. Hum Mol Genet 16:763–773. https://doi.org/10.1093/hmg/ddm012

Article  CAS  PubMed  Google Scholar 

Roy A, Lin YN, Agno JE, DeMayo FJ, Matzuk MM (2007) Absence of tektin 4 causes asthenozoospermia and subfertility in male mice. Faseb J 21:1013–1025. https://doi.org/10.1096/fj.06-7035com

Article  CAS  PubMed  Google Scholar 

Roy A, Lin YN, Agno JE, DeMayo FJ, Matzuk MM (2009) Tektin 3 is required for progressive sperm motility in mice. Mol Reprod Dev 76:453–459. https://doi.org/10.1002/mrd.20957

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shahrokhi SZ, Salehi P, Alyasin A, Taghiyar S, Deemeh MR (2020) Asthenozoospermia: cellular and molecular contributing factors and treatment strategies. Andrologia. https://doi.org/10.1111/and.13463

Article  PubMed  Google Scholar 

Suganuma R, Yanagimachi R, Meistrich ML (2005) Decline in fertility of mouse sperm with abnormal chromatin during epididymal passage as revealed by ICSI. Hum Reprod 20:3101–3108. https://doi.org/10.1093/humrep/dei169

Article  CAS  PubMed  Google Scholar 

Sun XH, Zhu YY, Wang L, Liu HL, Ling Y, Li ZL, Sun LB (2017) The catsper channel and its roles in male fertility: a systematic review. Reprod Biol Endocrinol 15:1–12. https://doi.org/10.1186/s12958-017-0281-2

Article