Developing novel antibacterial materials and therapeutic strategy to combat multidrug-resistant bacteria are currently very active research area. Photoactivation nano-antibacterial agents have attracted more and more interest because of their multimodal antibacterial effect and no drug resistance. In this study, a novel visible light-activated antibacterial composite (BODIPY- ZIF-90) is synthetized by grafting boron dipyrromethene (BODIPY) photosensitizer on ZIF-90 via simple aldehyde and amine condensation reaction. BODIPY-ZIF-90 is uniform rhombic dodecahedron structure with diameters 110 nm and micropore volume of 0.03 cm3/g. Compared with individual ZIF-90 and BODIPY photosensitizer, BODIPY-ZIF-90 exhibit strong synergistic visible light-induced (LED 7W) antibiotic property and MIC is about 5 µg /mL to the E. coli and S. aureus. BODIPY photosensitizer broaden light absorption region of the composite, simultaneously high porosity of ZIF-90 inhibits BODIPY aggregation. The synergetic effect between BODIPY photosensitizer and ZIF-90 improves ROS generation and accelerates the Zn ions release, which are favorable for light-activated antibacterial activity of BODIPY-ZIF-90. Our work not only provides a feasible strategy to build light-responsive antibacterial nanoplatform, but introduce a simple fabrication method for stimuli-responsive porous materials.

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