*State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine

†Department of Pathology, Sun Yat-sen University Cancer Center

§Guangdong No. 2 Provincial People’s Hospital, Guangzhou, Guangdong

‡Department of Pathology, Peking University Shenzhen Hospital

∥Department of Pathology, Shenzhen People’s Hospital, Shenzhen, Guangdong, China

Y.L., X.Y., and L.T. contributed equally to this study.

This project was supported by the National Natural Science Foundation of China (No. 81802729, 82273046).

Y.H.: conceived and designed the experiments and provided supervision. Y.L.: performed and analyzed the results and wrote the manuscript. X.Y.: performed immunohistochemical staining, in situ hybridization (ISH) and double staining. L.T.: collected the information of the cases. W.Z., M.Z., S.L., L.W., Y.L., Z.Z, and J.Y.: provided constructive suggestions for this work. All authors read and approved the final manuscript.

Conflicts of Interest and Source of Funding: The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article.

Correspondence: Yuhua Huang, MD, PhD, Department of Pathology, Sun Yat-sen University Cancer Center, No. 651 Dongfeng East Road, Guangzhou, Guangdong 510060, China (e-mail: [email protected]).

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