Steroidal saponin SSPH I induces ferroptosis in HepG2 cells via regulating iron metabolism

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. https://doi.org/10.3322/caac.21492 (Epub 2018/09/13; PubMed PMID: 30207593).

Samant H, Amiri HS, Zibari GB. Addressing the worldwide hepatocellular carcinoma: epidemiology, prevention and management. J Gastrointest Oncol. 2021;12(Suppl 2):S361–S73. https://doi.org/10.21037/jgo.2020.02.08 (Epub 2021/08/24; PubMed PMID: 34422400; PubMed Central PMCID: PMCPMC8343080).

Yang JD, Hainaut P, Gores GJ, Amadou A, Plymoth A, Roberts LR. A global view of hepatocellular carcinoma: trends, risk, prevention and management. Nat Rev Gastroenterol Hepatol. 2019;16(10):589–604. https://doi.org/10.1038/s41575-019-0186-y (Epub 2019/08/24; PubMed PMID: 31439937; PubMed Central PMCID: PMCPMC6813818).

Luo L, Yao X, Xiang J, Huang F, Luo H. Identification of ferroptosis-related genes for overall survival prediction in hepatocellular carcinoma. Sci Rep. 2022;12(1):10007. https://doi.org/10.1038/s41598-022-14554-7 (Epub 2022/06/16; PubMed PMID: 35705729; PubMed Central PMCID: PMCPMC9200861).

Werth EG, Rajbhandari P, Stockwell BR, Brown LM. Time course of changes in sorafenib-treated hepatocellular carcinoma cells suggests involvement of phospho-regulated signaling in ferroptosis induction. Proteomics. 2020;20(10):e2000006. https://doi.org/10.1002/pmic.202000006 (Epub 2020/04/27; PubMed PMID: 32336023; PubMed Central PMCID: PMCPMC7305944).

Iseda N, Itoh S, Toshida K, Tomiyama T, Morinaga A, Shimokawa M, et al. Ferroptosis is induced by lenvatinib through fibroblast growth factor receptor-4 inhibition in hepatocellular carcinoma. Cancer Sci. 2022;113(7):2272–2287. https://doi.org/10.1111/cas.15378 (Epub 2022/04/26; PubMed PMID: 35466502; PubMed Central PMCID: PMCPMC9277415).

He Y, Fang D, Liang T, Pang H, Nong Y, Tang L, et al. Atractylodin may induce ferroptosis of human hepatocellular carcinoma cells. Ann Transl Med. 2021;9(20):1535. https://doi.org/10.21037/atm-21-4386 (Epub 2021/11/19; PubMed PMID: 34790741; PubMed Central PMCID: PMCPMC8576678).

Lin PL, Tang HH, Wu SY, Shaw NS, Su CL. Saponin formosanin C-induced ferritinophagy and ferroptosis in human hepatocellular carcinoma cells. Antioxidants (Basel). 2020;9(8). https://doi.org/10.3390/antiox9080682 (Epub 2020/08/06; PubMed PMID: 32751249; PubMed Central PMCID: PMCPMC7463707).

Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014;156(1–2):317–31. https://doi.org/10.1016/j.cell.2013.12.010 (Epub 2014/01/21; PubMed PMID: 24439385; PubMed Central PMCID: PMCPMC4076414).

Ma S, Henson ES, Chen Y, Gibson SB. Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells. Cell Death Dis. 2016;7:e2307. https://doi.org/10.1038/cddis.2016.208 (Epub 2016/07/22; PubMed PMID: 27441659; PubMed Central PMCID: PMCPMC4973350).

Ma S, Dielschneider RF, Henson ES, Xiao W, Choquette TR, Blankstein AR, et al. Ferroptosis and autophagy induced cell death occur independently after siramesine and lapatinib treatment in breast cancer cells. PLoS One. 2017;12(8):e0182921. https://doi.org/10.1371/journal.pone.0182921 (Epub 2017/08/23; PubMed PMID: 28827805; PubMed Central PMCID: PMCPMC5565111).

Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149(5):1060–1072. https://doi.org/10.1016/j.cell.2012.03.042 (Epub 2012/05/29; PubMed PMID: 22632970; PubMed Central PMCID: PMCPMC3367386).

Bin D. Chinese modern Yao medicine. Nanning: Guangxi Science and Technology Press; 2009.

Google Scholar 

Zhou JL, Huang XY, Qiu HC, Gan RZ, Zhou H, Zhu HQ, et al. SSPH I, a Novel anti-cancer saponin, inhibits autophagy and induces apoptosis via ROS accumulation and ERK1/2 signaling pathway in hepatocellular carcinoma cells. Onco Targets Ther. 2020;13:5979–5991. https://doi.org/10.2147/OTT.S253234 (Epub 2020/07/02; PubMed PMID: 32606806; PubMed Central PMCID: PMCPMC7320904).

Olson B. Assays for determination of protein concentration. Curr Protoc Pharmacol. 2016;73:A 3A 1–A 3A 32. https://doi.org/10.1002/cpph.3 (Epub 2016/06/02; PubMed PMID: 27248579).

Zhou Y, Yang J, Chen C, Li Z, Chen Y, Zhang X, et al. Polyphyllin III-induced ferroptosis in MDA-MB-231 triple-negative breast cancer cells can be protected against by KLF4-mediated upregulation of xCT. Front Pharmacol. 2021;12:670224. https://doi.org/10.3389/fphar.2021.670224 (Epub 2021/05/28; PubMed PMID: 34040532; PubMed Central PMCID: PMCPMC8141818).

Alakkal A, Thayyullathil F, Pallichankandy S, Subburayan K, Cheratta AR, Galadari S. Sanguinarine induces H(2)O(2)-dependent apoptosis and ferroptosis in human cervical cancer. Biomedicines. 2022;10(8). https://doi.org/10.3390/biomedicines10081795 (Epub 2022/07/28; PubMed PMID: 35892694; PubMed Central PMCID: PMCPMC9331761).

Su LJ, Zhang JH, Gomez H, Murugan R, Hong X, Xu D, et al. Reactive oxygen species-induced lipid peroxidation in apoptosis, autophagy, and ferroptosis. Oxid Med Cell Longev. 2019;2019:5080843. https://doi.org/10.1155/2019/5080843 (Epub 2019/11/19; PubMed PMID: 31737171; PubMed Central PMCID: PMCPMC6815535).

Zhang S, Xin W, Anderson GJ, Li R, Gao L, Chen S, et al. Double-edge sword roles of iron in driving energy production versus instigating ferroptosis. Cell Death Dis. 2022;13(1):40. https://doi.org/10.1038/s41419-021-04490-1 (Epub 2022/01/12; PubMed PMID: 35013137; PubMed Central PMCID: PMCPMC8748693).

Miotto G, Rossetto M, Di Paolo ML, Orian L, Venerando R, Roveri A, et al. Insight into the mechanism of ferroptosis inhibition by ferrostatin-1. Redox Biol. 2020;28:101328. https://doi.org/10.1016/j.redox.2019.101328 (Epub 2019/10/02; PubMed PMID: 31574461; PubMed Central PMCID: PMCPMC6812032).

Hongyu Z, Shen T, Shang C, Luo Y, Liu L, Yan J, Li Y, Huang S. Ciclopirox induces autophagy through reactive oxygen species-mediated activation of JNK signaling pathway. Oncotarget. 2014;5(20):10140–10150.

Singh M, Kapoor A, Bhatnagar A. Oxidative and reductive metabolism of lipid-peroxidation derived carbonyls. Chem Biol Interact. 2015;234:261–273. https://doi.org/10.1016/j.cbi.2014.12.028 (Epub 2015/01/07; PubMed PMID: 25559856; PubMed Central PMCID: PMCPMC4414726).

Koppula P, Zhuang L, Gan B. Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy. Protein Cell. 2021;12(8):599–620. https://doi.org/10.1007/s13238-020-00789-5 (Epub 2020/10/02; PubMed PMID: 33000412; PubMed Central PMCID: PMCPMC8310547).

Saito Y, Soga T. Amino acid transporters as emerging therapeutic targets in cancer. Cancer Sci. 2021;112(8):2958–2965. https://doi.org/10.1111/cas.15006 (Epub 2021/06/07; PubMed PMID: 34091991; PubMed Central PMCID: PMCPMC8353895).

Sun YW, Qiu HC, Ou MC, Chen RL, Liang G. Saponins isolated from Schizocapsa plantaginea inhibit human hepatocellular carcinoma cell growth in vivo and in vitro via mitogen-activated protein kinase signaling. Chin J Nat Med. 2018;16(1):29–40. https://doi.org/10.1016/S1875-5364(18)30027-X (Epub 2018/02/10; PubMed PMID: 29425588).

Du K, Oh SH, Dutta RK, Sun T, Yang WH, Chi JT, et al. Inhibiting xCT/SLC7A11 induces ferroptosis of myofibroblastic hepatic stellate cells but exacerbates chronic liver injury. Liver Int. 2021;41(9):2214–2227. https://doi.org/10.1111/liv.14945 (Epub 2021/05/16; PubMed PMID: 33991158; PubMed Central PMCID: PMCPMC8594404).

Feng H, Liu Y, Gan Y, Li M, Liu R, Liang Z, et al. AdipoR1 regulates ionizing radiation-induced ferroptosis in HCC cells through Nrf2/xCT pathway. Oxid Med Cell Longev. 2022;2022:8091464. https://doi.org/10.1155/2022/8091464 (Epub 2022/06/24; PubMed PMID: 35733794; PubMed Central PMCID: PMCPMC9208988).

Feng H, Schorpp K, Jin J, Yozwiak CE, Hoffstrom BG, Decker AM, et al. Transferrin receptor is a specific ferroptosis marker. Cell Rep. 2020;30(10):3411–3423 e7. https://doi.org/10.1016/j.celrep.2020.02.049 (Epub 2020/03/12; PubMed PMID: 32160546; PubMed Central PMCID: PMCPMC7172030).

Jin Y, Huynh DTN, Myung CS, Heo KS. Ginsenoside Rh1 prevents migration and invasion through mitochondrial ROS-mediated inhibition of STAT3/NF-kappaB signaling in MDA-MB-231 Cells. Int J Mol Sci. 2021;22(19). https://doi.org/10.3390/ijms221910458 (Epub 2021/10/14; PubMed PMID: 34638797; PubMed Central PMCID: PMCPMC8508665).

Huang Q, Li J, Ma M, Lv M, Hu R, Sun J, et al. High‑throughput screening identification of a small‑molecule compound that induces ferroptosis and attenuates the invasion and migration of hepatocellular carcinoma cells by targeting the STAT3/GPX4 axis. Int J Oncol. 2023;62(3). https://doi.org/10.3892/ijo.2023.5490 (Epub 2023/02/25; PubMed PMID: 36825585; PubMed Central PMCID: PMCPMC9946807).

Chen J, Zhao F, Yang H, Wen J, Tang Y, Wan F, et al. Gentian violet induces apoptosis and ferroptosis via modulating p53 and MDM2 in hepatocellular carcinoma. Am J Cancer Res. 2022;12(7):3357–72.

CAS  PubMed  PubMed Central  Google Scholar 

Wang Q, Bin C, Xue Q, Gao Q, Huang A, Wang K, et al. GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis. Cell Death Dis. 2021;12(5):426. https://doi.org/10.1038/s41419-021-03718-4 (Epub 2021/05/02; PubMed PMID: 33931597; PubMed Central PMCID: PMCPMC8087704).

Huang W, Chen K, Lu Y, Zhang D, Cheng Y, Li L, et al. ABCC5 facilitates the acquired resistance of sorafenib through the inhibition of SLC7A11-induced ferroptosis in hepatocellular carcinoma. Neoplasia. 2021;23(12):1227–1239. https://doi.org/10.1016/j.neo.2021.11.002 (Epub 2021/11/13; PubMed PMID: 34768109; PubMed Central PMCID: PMCPMC8591347).

Zheng J, Sato M, Mishima E, Sato H, Proneth B, Conrad M. Sorafenib fails to trigger ferroptosis across a wide range of cancer cell lines. Cell Death Dis. 2021;12(7):698. https://doi.org/10.1038/s41419-021-03998-w (Epub 2021/07/15; PubMed PMID: 34257282; PubMed Central PMCID: PMCPMC8277867).

Yamada N, Karasawa T, Kimura H, Watanabe S, Komada T, Kamata R, et al. Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure. Cell Death Dis. 2020;11(2):144. https://doi.org/10.1038/s41419-020-2334-2 (Epub 2020/02/26; PubMed PMID: 32094346; PubMed Central PMCID: PMCPMC7039960).

Jiang H, Zhang X, Yang W, Li M, Wang G, Luo Q. Ferrostatin-1 ameliorates liver dysfunction via reducing iron in thioacetamide-induced acute liver injury in Mice. Front Pharmacol. 2022;13:869794. https://doi.org/10.3389/fphar.2022.869794 (Epub 2022/05/03; PubMed PMID: 35496274; PubMed Central PMCID: PMCPMC9039014).

Eberhard Y, McDermott SP, Wang X, Gronda M, Venugopal A, Wood TE, et al. Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells. Blood. 2009;114(14):3064–3073. https://doi.org/10.1182/blood-2009-03-209965 (Epub 2009/07/11; PubMed PMID: 19589922).

Wu J, Liu H, Zhang G, Gu L, Zhang Y, Gao J, et al. Antileukemia effect of ciclopirox olamine is mediated by downregulation of intracellular ferritin and inhibition beta-Catenin-c-Myc signaling pathway in glucocorticoid resistant T-ALL Cell Lines. PLoS One. 2016;11(8):e0161509. https://doi.org/10.1371/journal.pone.0161509 (Epub 2016/08/24; PubMed PMID: 27551974; PubMed Central PMCID: PMCPMC4995032).

Derek C. K. Chan IG, Lori L. Burrows. Forging new antibiotic combinations under iron-limiting conditions. Antimicrob Agents Chemother. 2020. https://doi.org/10.1128/AAC.01909-19.

Kang R, Kroemer G, Tang D. The tumor suppressor protein p53 and the ferroptosis network. Free Radic Biol Med. 2019;133:162–168. https://doi.org/10.1016/j.freeradbiomed.2018.05.074 (Epub 2018/05/26; PubMed PMID: 29800655; PubMed Central PMCID: PMCPMC6251771).

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