Blocking prokineticin receptors attenuates synovitis and joint destruction in collagen-induced arthritis

Emery P, Buch M (2002) Treating rheumatoid arthritis with tumour necrosis factor alpha blockade. BMJ 324:312–313. https://doi.org/10.1136/bmj.324.7333.312

Article  PubMed  PubMed Central  Google Scholar 

Scott DL, Wolfe F, Huizinga TW (2010) Rheumatoid arthritis. Lancet 376:1094–1108. https://doi.org/10.1016/s0140-6736(10)60826-4

Article  PubMed  Google Scholar 

Andersson MLE, Svensson B, Bergman S (2013) Chronic widespread pain in patients with rheumatoid arthritis and the relation between pain and disease activity measures over the first 5 years. J Rheumatol 40:1977–1985. https://doi.org/10.3899/jrheum.130493

Article  PubMed  Google Scholar 

Shelef MA (2019) New relationships for old autoantibodies in rheumatoid arthritis. Arthritis Rheumatol 71:1396–1399. https://doi.org/10.1002/art.40879

Article  PubMed  PubMed Central  Google Scholar 

Elemam NM, Hannawi S, Maghazachi AA (2020) Role of chemokines and chemokine receptors in rheumatoid arthritis. Immunotargets Ther 9:43–56. https://doi.org/10.2147/itt.S243636

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kondo N, Kuroda T, Kobayashi D (2021) Cytokine networks in the pathogenesis of rheumatoid arthritis. Int J Mol Sci 22(20):10922. https://doi.org/10.3390/ijms222010922

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fang Q, Zhou C, Nandakumar KS (2020) Molecular and cellular pathways contributing to joint damage in rheumatoid arthritis. Mediators Inflamm 2020:3830212. https://doi.org/10.1155/2020/3830212

Article  CAS  PubMed  PubMed Central  Google Scholar 

Negri L, Lattanzi R (2011) Bv8-prokineticins and their receptors: modulators of pain. Curr Pharma Biotechnol 12:1720–1727. https://doi.org/10.2174/138920111798357410

Negri L, Ferrara N (2018) The prokineticins: neuromodulators and mediators of inflammation

Negri L, Maftei D (2018) Targeting the prokineticin system to control chronic pain and inflammation. Curr Med Chem 25:3883–3894. https://doi.org/10.2174/0929867324666170713102514

Maftei D, Vellani V, Artico M, Giacomoni C, Severini C, Lattanzi R (2020) Abnormal pain sensation in mice lacking the prokineticin receptor PKR2: interaction of PKR2 with transient receptor potential TRPV1 and TRPA1. Neurosci 427:16–28. https://doi.org/10.1016/j.neuroscience.2019.12.003

Martucci C, Franchi S, Giannini E, Tian H, Melchiorri P, Negri L, Sacerdote P (2006) Bv8, the amphibian homologue of the mammalian prokineticins, induces a proinflammatory phenotype of mouse macrophages. Br J Pharmacol 147:225–234. https://doi.org/10.1038/sj.bjp.0706467

Article  CAS  PubMed  Google Scholar 

Franchi S, Giannini E, Lattuada D, Lattanzi R, Tian H, Melchiorri P, Negri L, Panerai AE, Sacerdote P (2008) The prokineticin receptor agonist Bv8 decreases IL-10 and IL-4 production in mice splenocytes by activating prokineticin receptor-1. BMC Immunol 9:60. https://doi.org/10.1186/1471-2172-9-60

Article  CAS  PubMed  PubMed Central  Google Scholar 

Severini C, Lattanzi R, Maftei D, Marconi V, Ciotti MT, Petrocchi Passeri P, Florenzano F, Del Duca E, Caioli S, Zona C et al (2015) Bv8/prokineticin 2 is involved in Aβ-induced neurotoxicity. Sci Rep 5:15301. https://doi.org/10.1038/srep15301

Article  CAS  PubMed  PubMed Central  Google Scholar 

Caioli S, Severini C, Ciotti T, Florenzano F, Pimpinella D, Petrocchi Passeri P, Balboni G, Polisca P, Lattanzi R, Nisticò R et al (2017) Prokineticin system modulation as a new target to counteract the amyloid beta toxicity induced by glutamatergic alterations in an in vitro model of Alzheimer’s disease. Neuropharmacology 116:82–97. https://doi.org/10.1016/j.neuropharm.2016.12.012

Article  CAS  PubMed  Google Scholar 

Lattanzi R, Maftei D, Petrella C, Pieri M, Sancesario G, Schirinzi T, Bernardini S, Barbato C, Ralli M, Greco A et al (2019a) Involvement of the chemokine prokineticin-2 (PROK2) in Alzheimer’s disease: from animal models to the human pathology. Cells 8. https://doi.org/10.3390/cells8111430

Lattanzi R, Maftei D, Fullone MR, Miele R (2019) Identification and characterization of prokineticin receptor 2 splicing variant and its modulation in an animal model of Alzheimer’s disease. Neuropeptides 73:49–56. https://doi.org/10.1016/j.npep.2018.11.006

Article  CAS  PubMed  Google Scholar 

Maftei D, Ratano P, Fusco I, Marconi V, Squillace S, Negri L, Severini C, Balboni G, Steardo L, Bronzuoli MR et al (2019) The prokineticin receptor antagonist PC1 rescues memory impairment induced by β amyloid administration through the modulation of prokineticin system. Neuropharmacol 158:107739. https://doi.org/10.1016/j.neuropharm.2019.107739

Schirinzi T, Maftei D, Pieri M, Bernardini S, Mercuri NB, Lattanzi R, Severini C (2021) Increase of prokineticin-2 in serum of patients with Parkinson’s disease. Mov Disord 36:1031–1033. https://doi.org/10.1002/mds.28458

Article  CAS  PubMed  Google Scholar 

Lattanzi R, Miele R (2021) Versatile role of prokineticins and prokineticin receptors in neuroinflammation. Biomedicines 9:1648. https://doi.org/10.3390/biomedicines9111648

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheng MY, Leslie FM, Zhou QY (2006) Expression of prokineticins and their receptors in the adult mouse brain. J Comp Neurol 498:796–809. https://doi.org/10.1002/cne.21087

Article  CAS  PubMed  PubMed Central  Google Scholar 

Negri L, Lattanzi R, Giannini E, Melchiorri P (2006) Modulators of pain: Bv8 and prokineticins. Curr Neuropharmacol 4:207–215. https://doi.org/10.2174/157015906778019518

Article  CAS  PubMed  PubMed Central  Google Scholar 

Giannini E, Lattanzi R, Nicotra A, Campese AF, Grazioli P, Screpanti I, Balboni G, Salvadori S, Sacerdote P, Negri L (2009) The chemokine Bv8/prokineticin 2 is up-regulated in inflammatory granulocytes and modulates inflammatory pain. Proc Natl Acad Sci U S A 106:14646–14651. https://doi.org/10.1073/pnas.0903720106

Article  PubMed  PubMed Central  Google Scholar 

Kurosaka D, Noda K, Yoshida K, Furuya K, Ukichi T, Takahashi E, Yanagimachi M, Kingetsu I, Saito S, Yamada A (2009) Elevation of Bombina variegata peptide 8 in mice with collagen-induced arthritis. BMC Musculoskelet Disord 10:45. https://doi.org/10.1186/1471-2474-10-45

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ito H, Noda K, Yoshida K, Otani K, Yoshiga M, Oto Y, Saito S, Kurosaka D (2016) Prokineticin 2 antagonist, PKRA7 suppresses arthritis in mice with collagen-induced arthritis. BMC Musculoskelet Disord 17:387. https://doi.org/10.1186/s12891-016-1243-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Noda K, Dufner B, Ito H, Yoshida K, Balboni G, Straub RH (2021) Differential inflammation-mediated function of prokineticin 2 in the synovial fibroblasts of patients with rheumatoid arthritis compared with osteoarthritis. Sci Rep 11:18399. https://doi.org/10.1038/s41598-021-97809-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Balboni G, Lazzari I, Trapella C, Negri L, Lattanzi R, Giannini E, Nicotra A, Melchiorri P, Visentin S, Nuccio CD, Salvadori S (2008) Triazine compounds as antagonists at Bv8-prokineticin receptors. J Med Chem 51:7635–7639. https://doi.org/10.1021/jm800854e

Article  CAS  PubMed  Google Scholar 

Maftei D, Marconi V, Florenzano F, Giancotti LA, Castelli M, Moretti S, Borsani E, Rodella LF, Balboni G, Luongo L et al (2014) Controlling the activation of the Bv8/prokineticin system reduces neuroinflammation and abolishes thermal and tactile hyperalgesia in neuropathic animals. Br J Pharmacol 171:4850–4865. https://doi.org/10.1111/bph.12793

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lattanzi R, Maftei D, Marconi V, Florenzano F, Franchi S, Borsani E, Rodella LF, Balboni G, Salvadori S, Sacerdote P et al (2015) Prokineticin 2 upregulation in the peripheral nervous system has a major role in triggering and maintaining neuropathic pain in the chronic constriction injury model. Biomed Res Int 2015:301292. https://doi.org/10.1155/2015/301292

Guida F, Lattanzi R, Boccella S, Maftei D, Romano R, Marconi V, Balboni G, Salvadori S, Scafuro MA, de Novellis V et al (2015) PC1, a non-peptide PKR1-preferring antagonist, reduces pain behavior and spinal neuronal sensitization in neuropathic mice. Pharmacol Res 91:36–46. https://doi.org/10.1016/j.phrs.2014.11.004

Article  CAS  PubMed  Google Scholar 

Castelli M, Amodeo G, Negri L, Lattanzi R, Maftei D, Gotti C, Pistillo F, Onnis V, Congu C, Panerai AE et al (2016) Antagonism of the prokineticin system prevents and reverses allodynia and inflammation in a mouse model of diabetes. PLoS One 11:e0146259. https://doi.org/10.1371/journal.pone.0146259

Moschetti G, Amodeo G, Maftei D, Lattanzi R, Procacci P, Sartori P, Balboni G, Onnis V, Conte V, Panerai A et al (2019) Targeting prokineticin system counteracts hypersensitivity, neuroinflammation, and tissue damage in a mouse model of bortezomib-induced peripheral neuropathy. J Neuroinflammation 16:89. https://doi.org/10.1186/s12974-019-1461-0

Article  PubMed  PubMed Central  Google Scholar 

Impellizzeri D, Siracusa R, Cordaro M, Peritore AF, Gugliandolo E, D'amico R, Fusco R, Crupi R, Rizzarelli E, Cuzzocrea S et al (2020) Protective effect of a new hyaluronic acid -carnosine conjugate on the modulation of the inflammatory response in mice subjected to collagen-induced arthritis. Biomed Pharmacother 125:110023. https://doi.org/10.1016/j.biopha.2020.110023

Szabó C, Virág L, Cuzzocrea S, Scott GS, Hake P, O’Connor MP, Zingarelli B, Salzman A, Kun E (1998) Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly(ADP-ribose) synthase. Proc Natl Acad Sci U S A 95(7):3867–3872. https://doi.org/10.1073/pnas.95.7.3867

Article  PubMed  PubMed Central  Google Scholar 

Negri L, Lattanzi R, Tabacco F, Scolaro B, Rocchi R (1998) Glycodermorphins: opioid peptides with potent and prolonged analgesic activity and enhanced blood-brain barrier penetration. Br J Pharmacol 124:1516–1522. https://doi.org/10.1038/sj.bjp.0701971

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hargreaves K, Dubner R, Brown F, Flores C, Joris J (1988) A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32:77–88. https://doi.org/10.1016/0304-3959(88)90026-7

Article  CAS  PubMed  Google Scholar 

Impellizzeri D, Esposito E, Di Paola R, Ahmad A, Campolo M, Peli A, Morittu VM, Britti D, Cuzzocrea S (2013) Palmitoylethanolamide and luteolin ameliorate development of arthritis caused by injection of collagen type II in mice. Arthritis Res Ther 15:4055. https://doi.org/10.1186/ar4382

Article  CAS  Google Scholar 

Luczaj W, Jarocka-Karpinska I, Sierakowski S, Andrisic L, Zarkovic N, Skrzydlewska E (2014) Lipid peroxidation in rheumatoid arthritis; consequences and monitoring. Free Radic Biol Med 75(Suppl 1):S49. https://doi.org/10.1016/j.freeradbiomed.2014.10.816

Article  PubMed  Google Scholar 

Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351–358. https://doi.org/10.1016/0003-2697(79)90738-3

Article  CAS  PubMed 

留言 (0)

沒有登入
gif