What fungal CNS infections can teach us about neuroimmunology and CNS-specific immunity

ElsevierVolume 67, May 2023, 101751Seminars in ImmunologyAuthor links open overlay panelAbstract

Immunity to fungal infections of the central nervous system (CNS) is one of the most poorly understood subjects within the field of medical mycology. Yet, the majority of deaths from invasive fungal infections are caused by brain-tropic fungi. In recent years, there have been several significant discoveries in the regulation of neuroinflammation and the role of the immune system in tissue homeostasis within the CNS. In this review, I highlight five important advances in the neuroimmunology field over the last decade and discuss how we should capitalise on these discoveries to better understand the pathogenesis of fungal CNS infections. In addition, the latest insights into fungal invasion tactics, microglia-astrocyte crosstalk and regulation of antifungal adaptive immune responses are summarised in the context of our contemporary understanding of CNS-specific immunity.

Keywords

Cryptococcus

Card9

Microglia

Candida

Astrocyte

Meninges

Blood-brain-barrier

© 2023 The Author(s). Published by Elsevier Ltd.

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