Dooley, D. J., Taylor, C. P., Donevan, S. & Feltner, D. Ca2+ channel α2δ ligands: novel modulators of neurotransmission. Trends Pharmacol. Sci. 28, 75–82 (2007).
Article CAS PubMed Google Scholar
Taylor, C. P., Angelotti, T. & Fauman, E. Pharmacology and mechanism of action of pregabalin: the calcium channel α2-δ (α2-δ) subunit as a target for antiepileptic drug discovery. Epilepsy Res. 73, 137–150 (2007).
Article CAS PubMed Google Scholar
Field, M. J. et al. Identification of the α2-δ-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin. Proc. Natl Acad. Sci. USA 103, 17537–17542 (2006).
Article CAS PubMed PubMed Central Google Scholar
Domon, Y. et al. Binding characteristics and analgesic effects of Mirogabalin, a novel ligand for the α2δ subunit of voltage-gated calcium channels. J. Pharmacol. Exp. Ther. 365, 573–582 (2018).
Article CAS PubMed Google Scholar
Kato, J., Inoue, T., Yokoyama, M. & Kuroha, M. A review of a new voltage-gated Ca2+ channel α2δ ligand, mirogabalin, for the treatment of peripheral neuropathic pain. Expert Opin. Pharmacother. 22, 2311–2322 (2021).
Article CAS PubMed Google Scholar
Gee, N. S. et al. The novel anticonvulsant drug, gabapentin (Neurontin), binds to the α2δ subunit of a calcium channel. J. Biol. Chem. 271, 5768–5776 (1996).
Article CAS PubMed Google Scholar
Bauer, C. S. et al. The increased trafficking of the calcium channel subunit α2δ-1 to presynaptic terminals in neuropathic pain is inhibited by the α2δ ligand pregabalin. J. Neurosci. 29, 4076–4088 (2009).
Article CAS PubMed PubMed Central Google Scholar
Cassidy, J. S., Ferron, L., Kadurin, I., Pratt, W. S. & Dolphin, A. C. Functional exofacially tagged N-type calcium channels elucidate the interaction with auxiliary α2δ-1 subunits. Proc. Natl Acad. Sci. USA 111, 8979–8984 (2014).
Article CAS PubMed PubMed Central Google Scholar
Marais, E., Klugbauer, N. & Hofmann, F. Calcium channel α2δ subunits-structure and Gabapentin binding. Mol. Pharmacol. 59, 1243–1248 (2001).
Article CAS PubMed Google Scholar
Qin, N., Yagel, S., Momplaisir, M. L., Codd, E. E. & D’Andrea, M. R. Molecular cloning and characterization of the human voltage-gated calcium channel α2δ-4 subunit. Mol. Pharmacol. 62, 485–496 (2002).
Article CAS PubMed Google Scholar
Meyer, J. O. & Dolphin, A. C. Rab11-dependent recycling of calcium channels is mediated by auxiliary subunit α2δ-1 but not α2δ-3. Sci. Rep. 11, 10256 (2021).
Article CAS PubMed PubMed Central Google Scholar
Tran-Van-Minh, A. & Dolphin, A. C. The α2δ ligand gabapentin inhibits the Rab11-dependent recycling of the calcium channel subunit α2δ-2. J. Neurosci. 30, 12856–12867 (2010).
Article CAS PubMed PubMed Central Google Scholar
Chen, Z. et al. EMC holdase:CaV1.2/CaVβ3 complex and CaV1.2 channel structures reveal CaV assembly and drug binding mechanisms. Preprint at bioRxiv https://doi.org/10.1101/2022.10.03.510667 (2022).
Zamponi, G. W., Striessnig, J., Koschak, A. & Dolphin, A. C. The physiology, pathology and pharmacology of voltage-gated calcium channels and their future therapeutic potential. Pharm. Rev. 67, 821–870 (2015).
Article CAS PubMed PubMed Central Google Scholar
Nanou, E. & Catterall, W. A. Calcium channels, synaptic plasticity and neuropsychiatric disease. Neuron 98, 466–481 (2018).
Article CAS PubMed Google Scholar
Buraei, Z. & Yang, J. The β subunit of voltage-gated Ca2+ channels. Physiol. Rev. 90, 1461–1506 (2010).
Article CAS PubMed Google Scholar
Dolphin, A. C. Voltage-gated calcium channels and their auxiliary subunits: physiology and pathophysiology and pharmacology. J. Physiol. 594, 5369–5390 (2016).
Article CAS PubMed PubMed Central Google Scholar
Brown, J. P., Dissanayake, V. U., Briggs, A. R., Milic, M. R. & Gee, N. S. Isolation of the [3H]gabapentin-binding protein/α2δ Ca2+ channel subunit from porcine brain: development of a radioligand binding assay for α2δ subunits using [3H]leucine. Anal. Biochem. 255, 236–243 (1998).
Article CAS PubMed Google Scholar
Dolphin, A. C. Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond. Nat. Rev. Neurosci. 13, 542–555 (2012).
Article CAS PubMed Google Scholar
David, D. J., Donovan, C. M., Meder, W. P. & Whetzel, S. Z. Preferential action of gabapentin and pregabalin at P/Q-type voltage-sensitive calcium channels: inhibition of K+-evoked [3H]-norepinephrine release from rat neocortical slices. Synapse 45, 171–190 (2002).
Anantharaman, V. & Aravind, L. Cache—a signaling domain common to animal Ca2+-channel subunits and a class of prokaryotic chemotaxis receptors. Trends Biochem. Sci. 25, 535–537 (2000).
Article CAS PubMed Google Scholar
Jonikas, M. C. et al. Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum. Science 323, 1693–1697 (2009).
Article CAS PubMed PubMed Central Google Scholar
Christianson, J. C. et al. Defining human ERAD networks through an integrative mapping strategy. Nat. Cell Biol. 14, 93–105 (2011).
Article PubMed PubMed Central Google Scholar
Hegde, R. S. The function, structure, and origins of the ER membrane protein complex. Annu. Rev. Biochem. 91, 651–678 (2022).
Wu, J. et al. Structure of the voltage-gated calcium channel Cav1.1 at 3.6 Å resolution. Nature 537, 191–196 (2016).
Article CAS PubMed Google Scholar
Yao, X., Gao, S. & Yan, N. Structural basis for pore blockade of human voltage-gated calcium channel Cav1.3 by motion sickness drug cinnarizine. Cell Res. 32, 946–948 (2022).
Article CAS PubMed PubMed Central Google Scholar
Gao, S., Yao, X. & Yan, N. Structure of human Cav2.2 channel blocked by the painkiller ziconotide. Nature 596, 143–147 (2021).
Article CAS PubMed PubMed Central Google Scholar
Gumerov, V. M. et al. Amino acid sensor conserved from bacteria to humans. Proc. Natl Acad. Sci. USA 119, e2110415119 (2022).
Article CAS PubMed PubMed Central Google Scholar
Canti, C. et al. The metal-ion-dependent adhesion site in the von Willebrand factor-A domain of α2δ subunits is key to trafficking voltage-gated Ca2+ channels. Proc. Natl Acad. Sci. USA 102, 11230–11235 (2005).
Article CAS PubMed PubMed Central Google Scholar
Wang, M., Offord, J., Oxender, D. L. & Su, T. Z. Structural requirement of the calcium-channel subunit α2δ for gabapentin binding. Biochem. J. 342, 313–320 (1999).
Article CAS PubMed PubMed Central Google Scholar
Oyama, M., Watanabe, S., Iwai, T. & Tanabe, M. Mirogabalin activates the descending noradrenergic system by binding to the α2δ-1 subunit of voltage-gated Ca2+ channels to generate analgesic effects. J. Pharm. Sci. 146, 33–39 (2021).
Lotarski, S. et al. Anticonvulsant activity of pregabalin in the maximal electroshock-induced seizure assay in α2δ1 (R217A) and α2δ2 (R279A) mouse mutants. Epilepsy Res. 108, 833–842 (2014).
Article CAS PubMed Google Scholar
Lotarski, S. M. et al. Anxiolytic-like activity of pregabalin in the Vogel conflict test in α2δ-1 (R217A) and α2δ-2 (R279A) mouse mutants. J. Pharmacol. Exp. Ther. 338, 615–621 (2011).
Article CAS PubMed Google Scholar
Gavira, J. A. et al. How bacterial chemoreceptors evolve novel ligand specificities. mBio https://doi.org/10.1128/mBio.03066-19 (2020).
Page, K. M., Gumerov, V. M., Dahimene, S., Zhulin, I. B. & Dolphin, A. C. The importance of cache domains in α2δ proteins and the basis for their gabapentinoid selectivity. Channels (Austin) 17, 2167563 (2023).
Article PubMed PubMed Central Google Scholar
Dahimene, S. et al. The α2δ-like protein Cachd1 increases N-type calcium currents and cell surface expression and competes with α2δ-1. Cell Rep. 25, 1610–1621 (2018).
Article CAS PubMed PubMed Central Google Scholar
Wallace, A. C., Laskowski, R. A. & Thornton, J. M. LIGPLOT: a program to gene
留言 (0)