Moreau R, Jalan R, Gines P, et al. CANONIC Study Investigators of the EASL–CLIF Consortium. Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis. Gastroenterology. 2013;144:1426–1437
Zaccherini G, Weiss E, Moreau R. Acute-on-chronic liver failure: definitions, pathophysiology and principles of treatment. JHEP Rep. 2021;3: 100176
Laleman W, Claria J, Van der Merwe S, et al. Systemic inflammation and acute-on-chronic liver failure: too much not enough. Can J Gastroenterol Hepatol. 2018;2018:1027152
Article PubMed PubMed Central Google Scholar
Zhang GL, Xie DY, Lin BL, et al. Imbalance of interleukin-17-producing CD4 T cells/regulatory T cells axis occurs in remission stage of patients with hepatitis B virus-related acute-on-chronic liver failure. J Gastroenterol Hepatol. 2013;28:513–521
Article CAS PubMed Google Scholar
Li Q, Wang J, Lu M, et al. Acute-on-chronic liver failure from chronic-hepatitis-B, who is the behind scenes. Front Microbiol. 2020;11: 583423
Article PubMed PubMed Central Google Scholar
Zhou X, Li Y, Ji Y, et al. PD-1 involvement in peripheral blood CD8+ T lymphocyte dysfunction in patients with acute-on-chronic liver failure. J Clin Transl Hepatol. 2021;9:283–290
PubMed PubMed Central Google Scholar
Wang L, Rubinstein R, Lines JL, et al. VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses. J Exp Med. 2011;208:577–592
Article CAS PubMed PubMed Central Google Scholar
Flies DB, Wang S, Xu H, et al. Cutting edge: a monoclonal antibody specific for the programmed death-1 homolog prevents graft-versus-host disease in mouse models. J Immunol. 2011;187:1537–1541
Article CAS PubMed Google Scholar
Kunishige T, Taniguchi H, Ohno T, et al. VISTA is crucial for corneal allograft survival and maintenance of immune privilege. Invest Ophthalmol Vis Sci. 2019;60:4958–4965
Article CAS PubMed Google Scholar
Flies DB, Han X, Higuchi T, et al. Coinhibitory receptor PD-1H preferentially suppresses CD4(+) T cell-mediated immunity. J Clin Invest. 2014;124:1966–1975
Article CAS PubMed PubMed Central Google Scholar
Wang L, Le Mercier I, Putra J, et al. Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity. Proc Natl Acad Sci U S A. 2014;111:14846–14851
Article CAS PubMed PubMed Central Google Scholar
Derakhshani A, Asadzadeh Z, Baradaran B, et al. The expression pattern of VISTA in the PBMCs of relapsing-remitting multiple sclerosis patients: a single-cell RNA sequencing-based study. Biomed Pharmacother. 2022;148: 112725
Article CAS PubMed Google Scholar
Hid Cadena R, Reitsema RD, Huitema MG, et al. Decreased expression of negative immune checkpoint VISTA by CD4+ T Cells Facilitates T Helper 1, T Helper 17, and T follicular helper lineage differentiation in GCA. Front Immunol. 2019;10:1638
Article PubMed PubMed Central Google Scholar
Ceeraz S, Sergent PA, Plummer SF, et al. VISTA deficiency accelerates the development of fatal murine lupus nephritis. Arthritis Rheumatol. 2017;69:814–825
Article CAS PubMed PubMed Central Google Scholar
Sarin SK, Choudhury A, Sharma MK, et al. APASL ACLF Research Consortium (AARC) for APASL ACLF working party. Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update. Hepatol Int. 2019;13:353–390
Kamath PS, Kim WR. The model for end-stage liver disease (MELD). Hepatology. 2007;4:797–805
Biggins SW, Kim WR, Terrault NA, et al. Evidence-based incorporation of serum sodium concentration into MELD. Gastroenterology. 2006;130:1652–1660
Jalan R, Saliba F, Pavesi M, et al. CANONIC study investigators of the EASL-CLIF Consortium. Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure. J Hepatol. 2014;61:1038–1047
Sarin SK, Choudhury A. Acute-on-chronic liver failure: terminology, mechanisms and management. Nat Rev Gastroenterol Hepatol. 2016;13:131–149
Article CAS PubMed Google Scholar
Wang LY, Meng QH, Zou ZQ, et al. Increased frequency of circulating Th17 cells in acute-on-chronic hepatitis B liver failure. Dig Dis Sci. 2012;57:667–674
Article CAS PubMed Google Scholar
Xu C, Lu Y, Zheng X, et al. TLR2 expression in peripheral CD4+ T cells promotes Th17 response and is associated with disease aggravation of hepatitis B virus-related acute-on-chronic liver failure. Front Immunol. 2017;8:1609
Article PubMed PubMed Central Google Scholar
Harris TJ, Grosso JF, Yen HR, et al. Cutting edge: an in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity. J Immunol. 2007;179:4313–4317
Article CAS PubMed Google Scholar
Xiang X, Feng D, Hwang S, et al. Interleukin-22 ameliorates acute-on-chronic liver failure by reprogramming impaired regeneration pathways in mice. J Hepatol. 2020;72:736–745
Article CAS PubMed Google Scholar
Triantafyllou E, Woollard KJ, McPhail MJW, et al. The role of monocytes and macrophages in acute and acute-on-chronic liver failure. Front Immunol. 2018;9:2948
Article CAS PubMed PubMed Central Google Scholar
Bharaj P, Chahar HS, Alozie OK, et al. Characterization of programmed death-1 homologue-1 (PD-1H) expression and function in normal and HIV infected individuals. PLoS ONE. 2014;9: e109103
Article PubMed PubMed Central Google Scholar
Rogers BM, Smith L, Dezso Z, et al. VISTA is an activating receptor in human monocytes. J Exp Med. 2021;218: e20201601
Article CAS PubMed PubMed Central Google Scholar
Bharaj P, Ye C, Petersen S, et al. Gene array analysis of PD-1H overexpressing monocytes reveals a pro-inflammatory profile. Heliyon. 2018;4: e00545
Article PubMed PubMed Central Google Scholar
ElTanbouly MA, Zhao Y, Schaafsma E, et al. VISTA: a target to manage the innate cytokine storm. Front Immunol. 2021;11: 595950
Article PubMed PubMed Central Google Scholar
ElTanbouly MA, Zhao Y, Nowak E, et al. VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance. Science. 2020;367:eaay0524
Article CAS PubMed PubMed Central Google Scholar
Seto WK, Lai CL, Yuen MF. Acute-on-chronic liver failure in chronic hepatitis B. J Gastroenterol Hepatol. 2012;27:662–669
Xu W, Hiếu T, Malarkannan S, et al. The structure, expression, and multifaceted role of immune-checkpoint protein VISTA as a critical regulator of anti-tumor immunity, autoimmunity, and inflammation. Cell Mol Immunol. 2018;15:438–446
Article CAS PubMed PubMed Central Google Scholar
Li N, Xu W, Yuan Y, et al. Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis. Sci Rep. 2017;7:1485
Article PubMed PubMed Central Google Scholar
Zhang M, Zhou L, Xu Y, et al. A STAT3 palmitoylation cycle promotes T17 differentiation and colitis. Nature. 2020;586:434–439
Article CAS PubMed PubMed Central Google Scholar
Nautiyal N, Maheshwari D, Tripathi DM, et al. Establishment of a murine model of acute-on-chronic liver failure with multi-organ dysfunction. Hepatol Int. 2021;15:1389–1401
Flies DB, Higuchi T, Chen L. Mechanistic assessment of PD-1H coinhibitory receptor-induced T cell tolerance to allogeneic antigens. J Immunol. 2015;194:5294–5304
Article CAS PubMed Google Scholar
Delaney B, Strom SC, Collins S, et al. Carbon tetrachloride suppresses T-cell-dependent immune responses by induction of transforming growth factor-beta 1. Toxicol Appl Pharmacol. 1994;126:98–107
Article CAS PubMed Google Scholar
Radaeva S, Sun R, Pan HN, et al. Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Hepatology. 2004;39:1332–1342
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