Baumeister, S. H., Freeman, G. J., Dranoff, G. & Sharpe, A. H. Coinhibitory pathways in immunotherapy for cancer. Annu. Rev. Immunol. 34, 539–573 (2016).
Article CAS PubMed Google Scholar
Topalian, S. L., Drake, C. G. & Pardoll, D. M. Immune checkpoint blockade: a common denominator approach to cancer therapy. Cancer Cell 27, 450–461 (2015).
Article CAS PubMed PubMed Central Google Scholar
Sharma, P. & Allison, J. P. The future of immune checkpoint therapy. Science 348, 56–61 (2015).
Article CAS PubMed Google Scholar
Okazaki, T., Chikuma, S., Iwai, Y., Fagarasan, S. & Honjo, T. A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application. Nat. Immunol. 14, 1212–1218 (2013).
Article CAS PubMed Google Scholar
Rizvi, N. A. et al. Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial. Lancet Oncol. 16, 257–265 (2015).
Article CAS PubMed PubMed Central Google Scholar
Ansell, S. M. et al. PD-1 blockade with nivolumab in relapsed or refractory Hodgkin’s lymphoma. N. Engl. J. Med. 372, 311–319 (2015).
André, P. et al. Anti-NKG2A mAb is a checkpoint inhibitor that promotes anti-tumor immunity by unleashing both T and NK cells. Cell 175, 1731–1743.e1713 (2018).
Article PubMed PubMed Central Google Scholar
McWilliams, E. M. et al. Therapeutic CD94/NKG2A blockade improves natural killer cell dysfunction in chronic lymphocytic leukemia. Oncoimmunology 5, e1226720 (2016).
Article PubMed PubMed Central Google Scholar
Kamiya, T., Seow, S. V., Wong, D., Robinson, M. & Campana, D. Blocking expression of inhibitory receptor NKG2A overcomes tumor resistance to NK cells. J. Clin. Invest. 129, 2094–2106 (2019).
Article PubMed PubMed Central Google Scholar
Topalian, S. L. et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N. Engl. J. Med. 366, 2443–2454 (2012).
Article CAS PubMed PubMed Central Google Scholar
Hamid, O. et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N. Engl. J. Med. 369, 134–144 (2013).
Article CAS PubMed PubMed Central Google Scholar
Zou, W. Mechanistic insights into cancer immunity and immunotherapy. Cell. Mol. Immunol. 15, 419–420 (2018).
Article CAS PubMed PubMed Central Google Scholar
Barry, K. C. et al. A natural killer–dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments. Nat. Med. 24, 1178–1191 (2018).
Article CAS PubMed PubMed Central Google Scholar
Zheng, X. et al. Mitochondrial fragmentation limits NK cell-based tumor immunosurveillance. Nat. Immunol. 20, 1656–1667 (2019).
Article CAS PubMed Google Scholar
Ghesquière, B., Wong, B. W., Kuchnio, A. & Carmeliet, P. Metabolism of stromal and immune cells in health and disease. Nature 511, 167–176 (2014).
Morvan, M. G. & Lanier, L. L. NK cells and cancer: you can teach innate cells new tricks. Nat. Rev. Cancer 16, 7–19 (2016).
Article CAS PubMed Google Scholar
O’Brien, K. L. & Finlay, D. K. Immunometabolism and natural killer cell responses. Nat. Rev. Immunol. 19, 282–290 (2019).
Orange, J. S. Formation and function of the lytic NK-cell immunological synapse. Nat. Rev. Immunol. 8, 713–725 (2008).
Article CAS PubMed PubMed Central Google Scholar
Davis, D. M. et al. The human natural killer cell immune synapse. Proc. Natl Acad. Sci. USA 96, 15062–15067 (1999).
Article CAS PubMed PubMed Central Google Scholar
Williams, G. S. et al. Membranous structures transfer cell surface proteins across NK cell immune synapses. Traffic 8, 1190–1204 (2007).
Article CAS PubMed Google Scholar
McCann, F. E. et al. The size of the synaptic cleft and distinct distributions of filamentous actin, ezrin, CD43, and CD45 at activating and inhibitory human NK cell immune synapses. J. Immunol. 170, 2862–2870 (2003).
Article CAS PubMed Google Scholar
Mattaini, K. R., Sullivan, M. R. & Vander Heiden, M. G. The importance of serine metabolism in cancer. J. Cell Biol. 214, 249–257 (2016).
Article CAS PubMed PubMed Central Google Scholar
Herz, J. et al. Acid sphingomyelinase is a key regulator of cytotoxic granule secretion by primary T lymphocytes. Nat. Immunol. 10, 761–768 (2009).
Article CAS PubMed Google Scholar
Jung, Y. et al. Three-dimensional localization of T-cell receptors in relation to microvilli using a combination of superresolution microscopies. Proc. Natl Acad. Sci. USA 113, E5916–E5924 (2016).
Article CAS PubMed PubMed Central Google Scholar
Cai, E. et al. Visualizing dynamic microvillar search and stabilization during ligand detection by T cells. Science 356, eaal3118 (2017).
Article PubMed PubMed Central Google Scholar
Yi, J. C. & Samelson, L. E. Microvilli set the stage for T-cell activation. Proc. Natl Acad. Sci. USA 113, 11061–11062 (2016).
Article CAS PubMed PubMed Central Google Scholar
Kim, H.-R. et al. T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells. Nat. Commun. 9, 3630 (2018).
Article PubMed PubMed Central Google Scholar
Majstoravich, S. et al. Lymphocyte microvilli are dynamic, actin-dependent structures that do not require Wiskott-Aldrich syndrome protein (WASp) for their morphology. Blood 104, 1396–1403 (2004).
Article CAS PubMed Google Scholar
Pettmann, J., Santos, A. M., Dushek, O. & Davis, S. J. Membrane ultrastructure and T cell activation. Front. Immunol. 9, 2152 (2018).
Article PubMed PubMed Central Google Scholar
Razvag, Y., Neve-Oz, Y., Sajman, J., Reches, M. & Sherman, E. Nanoscale kinetic segregation of TCR and CD45 in engaged microvilli facilitates early T cell activation. Nat. Commun. 9, 732 (2018).
Article PubMed PubMed Central Google Scholar
Fisher, P. J., Bulur, P. A., Vuk-Pavlovic, S., Prendergast, F. G. & Dietz, A. B. Dendritic cell microvilli: a novel membrane structure associated with the multifocal synapse and T-cell clustering. Blood 112, 5037–5045 (2008).
Article CAS PubMed Google Scholar
Sivori, S. et al. Human NK cells: surface receptors, inhibitory checkpoints, and translational applications. Cell. Mol. Immunol. 16, 430–441 (2019).
Article CAS PubMed PubMed Central Google Scholar
Habif, G., Crinier, A., André, P., Vivier, E. & Narni-Mancinelli, E. Targeting natural killer cells in solid tumors. Cell. Mol. Immunol. 16, 415–422 (2019).
Article CAS PubMed PubMed Central Google Scholar
Kumari, S. et al. Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway. eLife 4, e04953 (2015).
Article PubMed PubMed Central Google Scholar
Zhu, H. et al. Single-neuron identification of chemical constituents, physiological changes, and metabolism using mass spectrometry. Proc. Natl Acad. Sci. USA 114, 2586–2591 (2017).
Article CAS PubMed PubMed Central Google Scholar
Zhu, H. et al. Moderate UV exposure enhances learning and memory by promoting a novel glutamate biosynthetic pathway in the brain. Cell 173, 1716–1727.e1717 (2018).
Article CAS PubMed Google Scholar
Zhuang,
留言 (0)