Bibliometric Analysis of Acupuncture Therapy for Cancer Pain Over the Past 10 Years

Introduction

Cancer pain, one of the most common symptoms in cancer patients, can be caused by cancer itself, including bone metastasis and cancer infiltrating soft tissues or pressing on nerves, and can also be induced by cancer treatment–related effects, including chemotherapy, surgery, or radiation. It is estimated that the annual incidence of cancer will rise to 19.3 million by 2025.1 A meta-analysis revealed that the prevalence rates of cancer pain were 55% among patients undergoing cancer treatment, 66.4% among patients with advanced disease, and 39.3% among patients after curative treatment.2 Unrelieved cancer pain contributes to the poor quality of life of cancer patients, followed by common symptoms including fatigue, sleep disturbance, and emotional distress, such as anxiety and depression.3 The main approaches to manage cancer pain recommended by the World Health Organization (WHO) consist of pharmacologic and radiotherapeutic approaches;4 of these, the appropriate application of opioids plays a vital role in alleviating pain for patients with cancer pain. However, side effects such as bowel dysfunction, nausea, vomiting, respiratory depression and neurotoxicity with the overuse of opioids5 and the possibility of tumor growth accelerated by opioids pose critical challenges to pain management in cancer patients.6 Therefore, the application of supplementary treatment for cancer pain has broad application prospects.

Complementary therapies correspond to growing demand in patients with cancer pain,7 and complementary therapies for the treatment of cancer pain include acupuncture, dietary supplements, massage, guided imagery and cryotherapy.8 Acupuncture, as a nonpharmacologic intervention, has been widely used to relieve many different types of pain based on traditional Chinese medicine theories,9 such as lowback pain, knee osteoarthritis pain, headache pain, myofascial pain, other pain syndromes, etc.10 Many clinical trials have confirmed that acupuncture is effective in treating cancer pain.11–13 A systematic review and meta-analysis showed that acupuncture not only reduces cancer pain but also decreases the use of analgesics with moderate certainty of evidence.14 Acupuncture achieved curative effects in alleviating cancer pain, as verified by clinical studies, and several clinical guidelines suggest the use of acupuncture for managing cancer pain.15,16 Acupuncture has received increasing attention in this field. It is essential to investigate the current status, hotspots and research trends of acupuncture treatment for cancer pain through a quantitative analysis of the literature.

Bibliometric analysis, as a method of quantitatively analyzing publications using mathematics and statistics, can explore research advances, hot topics and potential problems in a specific field to promote future research and clinical application. In this study, CiteSpace was used to analyze the literature through multiple perspectives of journals, countries, institutions, authors, keywords, and references to obtain the current research hotspots and trends in the use of acupuncture treatment for cancer pain during the last decade.

Methods Data Sources and Search Strategy

All articles in this study were abstracted from the SCI-EXPANDED database in the Web of Science Core Collection through the Chengdu University of Traditional Chinese Medicine Library website from 2012–01-01 to 2022–08-20. The search was completed on August 21, 2022, and was restricted to English language articles but without limitations regarding the country of publication. The data search strategy included the topics “cancer”, “pain” and “acupuncture therapy”. The specific search strategy and results are shown in Table 1. Finally, we retrieved 655 papers. Of these, letters (19), meeting abstracts (19), book chapters (1), and articles not related to the search topic (314) were excluded. As a result, 302 records were included for further visualization and analysis.

Table 1 The Topic Search Query

Data Analysis

This study utilized CiteSpace 6.1. R3, a bibliometric software package, to organize and visualize the data from the included studies. The main results are presented in the form of a map, which consists of citation tree rings and lines. The citation tree rings indicate the frequency of appearance and citation frequency of the analyzed data. The lines between nodes represent the co-occurrence or citation relationships among the elements. The variation in color with node and line indicates different times.17,18 The greater the thickness of the node and line is, the greater the intensity of occurrence. Nodes with a larger centrality, especially represented by purple on the node ring, indicate the importance of nodes in a network.19

First, we clarified the annual output counts, prolific journals, countries (regions) and institutions to present the general information of the included papers. Then, CiteSpace showed the individual contributions of and cooperation between authors and cited authors. Furthermore, co-occurrence analysis, clustering analysis of keywords and citation burst analysis of keywords and references were performed to anchor research hotspots and target frontier areas. The parameters of CiteSpace were as follows: The threshold of “Top N% per slice” was 50 for all calculations. The time span was from January 2012 to February 2022, and the time slices were “1 year per slice”. Clustering labels were extracted by using the log-likelihood ratio (LLR) algorithm.

Results Annual Publications and Trends

In total, 302 articles were selected in accordance with the application of acupuncture for cancer pain over the past 10 years. From 2012 to 2022, the number of articles on acupuncture for cancer pain showed a fluctuating but steady upward trend (Figure 1). In 2012, there were only 8 articles published on this topic, which peaked with 23 articles on acupuncture for cancer pain in the next year. From 2013 to 2015, the number of publications experienced a steep decline. Along with the increasing attention, the number of publications experienced a second peak with steady and sustained growth from 2015 to 2018. After a mild decline in 2019 with 29 articles, the number of publications continued to grow until 2021. To date, there have been 32 articles published over 8 months in 2022, which predicts a considerable number of publications this year, and the research focus in this field will continue.

Figure 1 The number of annual publications on acupuncture for cancer pain.

Analysis of Journals

The number of journals that published 302 articles on acupuncture treatment for cancer pain was 50. Table 2 lists the top 10 active journals. Of these, the three highest-ranked journals were “Integrative Cancer Therapies” with 24 publications, ‘Medicine’ with 18 publications, and ‘Evidence-based Complementary and Alternative Medicine’ with 16 publications.

Table 2 Top 10 Journals with the Highest Frequency Values for Studies on Acupuncture Treatment for Cancer Pain

Analysis of Cited Journals

The analysis of the co-citation of journals shows a distribution of substantial knowledge sources and can be used to identify important journals in a particular field. As shown in Figure 2, we obtained a co-citation map of journals on acupuncture therapy for cancer pain with frequencies above 50 outputs generated by CiteSpace. The 5 most cited journals on acupuncture for cancer pain are listed in Table 3. The most frequent journal was the Journal of Clinical Oncology (202 counts), followed by Supportive Care in Cancer (154 counts), Evidence-based Complementary and Alternative Medicine (152 counts), Acupuncture in Medicine (143 counts), and Pain (137 counts). Table 4 lists the top 8 journals with high centrality in the field of acupuncture treatment for cancer pain. It should be noted that all the centrality values of the cited journals on acupuncture for cancer pain were below 1.

Table 3 Top 5 Cited Journals with the Highest Frequency Values for Acupuncture Treatment for Cancer Pain

Table 4 Top 8 Cited Journals with the Highest Centrality Values for Acupuncture Treatment for Cancer Pain

Figure 2 Co-citation map of journals on acupuncture therapy for cancer pain.

Analysis of Countries/Regions

The country collaboration network map (Figure 3) generated by CiteSpace shows that articles on acupuncture therapy for cancer pain mainly came from 39 countries/regions. In terms of the number of publications, the top five countries/regions were China (117 articles), the USA (96 articles), South Korea (26 articles), Taiwan (16 articles) and Australia (13 articles) (Table 5). China, where acupuncture originated, has formed cooperative relations with some countries, but such cooperative relations are far from sufficient. The USA, with the strongest centrality value of 0.46, cooperates with 16 countries and has formed a relatively mature cooperative network. However, China and the USA, as the top publishers with the greatest centrality, formed two cooperative networks and had fewer cooperative relations with each other. In addition, there was a relatively mature network between Brazil, Switzerland, Argentina, France, and India.

Table 5 Top 5 Countries with the Highest Frequency and Centrality Values for Acupuncture Treatment for Cancer Pain

Figure 3 Co-country map related to acupuncture treatment studies for cancer pain.

Analysis of Institutions

There were 252 institutions in the included articles. As shown in Table 6, the top 5 institutions with high volumes were Memorial Sloan Kettering Cancer Center (21 articles), Beijing University of Chinese Medicine (14 articles), Guangzhou University of Chinese Medicine (13 articles), Kyung Hee University (13 articles), and University of Texas MD Anderson Cancer Center (8 articles). Memorial Sloan Kettering Cancer Center had the highest centrality of 0.1, followed by Guangdong Province Academic Chinese Medicine Science (0.07), Beijing University of Chinese Medicine (0.05), Guangzhou University of Chinese Medicine (0.04), and Columbia University (0.04). Memorial Sloan Kettering Cancer Center had the highest number of articles and the highest centrality, indicating that it makes substantial contributions to this topic. Figure 4, generated by CiteSpace, shows the interinstitutional collaboration network.

Table 6 Top 5 Institutions with the Highest Frequency and Centrality Values for Acupuncture Treatment for Cancer Pain

Figure 4 Map of the interinstitutional collaboration network for acupuncture treatment for cancer pain.

Analysis of Authors and Cited Authors

A total of 295 authors were involved in the research on acupuncture therapy for cancer pain. The top 7 active authors are shown in Table 7. Mao JJ (19 studies) ranked first, followed by Bao Ting (10 studies) and Cohen Lorenzo (6 studies). The top 3 authors came from the USA. Figure 5 shows that the top 2 authors maintain considerable network cooperation with other authors. Interestingly, the top 2 authors came from the same institution. Figure 5 shows that a small network of collaborative relationships formed around high-frequency authors.

Table 7 Top 7 Authors with the Highest Frequency Values for Acupuncture Treatment for Cancer Pain

Figure 5 Map of authors’ cooperation network for acupuncture therapy for cancer pain.

Cited Authors

There were 412 cited authors involved in studies on acupuncture therapy for cancer pain. Table 8 lists the top 5 most frequently co-cited authors. Lu WD and Bao Ting were the most frequently co-cited authors, with 66 counts, followed by Hershman DL and Garcia MK (59 counts) and Mao JJ (56 counts). Notably, all the top 5 co-cited authors came from the USA. The top 5 co-cited authors with the greatest centrality shown in Table 8 were Molassiotis A, Lu WD, Bao T, Alimi D, and Lee JH. Figure 6 shows the cited authors with a frequency greater than 20.

Table 8 Top 5 Cited Authors with the Highest Frequency and Centrality Values for Acupuncture Treatment for Cancer Pain

Figure 6 Map of cited authors in studies on acupuncture therapy for cancer pain.

Keyword Co-Occurrence Analysis

Keywords with high frequency and high centrality can summarize current research hotspots in a specific field. Generated by CiteSpace, we obtained a map of co-occurrence with a total of 296 keywords (Figure 7). The 10 top most frequent keywords are listed in Table 9. The five most frequent keywords were “acupuncture”, “management”, “quality of life”, “breast cancer”, and “pain”. Table 9 shows the top 10 keywords with the greatest centrality, and “acupuncture”, “breast cancer”, “electroacupuncture”, and “randomized controlled trial” were ranked in the top four.

Table 9 Top 10 Keywords with the Highest Frequency and Centrality Values for Acupuncture Treatment for Cancer Pain

Figure 7 Co-occurrence map of keywords for acupuncture therapy for cancer pain.

All the keywords were classified into 9 clusters based on the co-occurrence map. As shown in Figure 8, the five largest clusters were “bee venom acupuncture”, “multiple myeloma”, “postoperative pain”, “breast cancer patient”, and “acupuncture use”, which were the most talked about topics in this area.

Figure 8 Cluster map of keyword cooccurrence for acupuncture therapy for cancer pain.

A burst keyword is a keyword that emerges substantially within a short period. This information shows the elevation of research hotspots over time, indicates the research trends in recent years and may suggest those of the future. Figure 9 shows the top 7 keywords with the strongest citation bursts over the last 10 years. The most recent burst keywords were “mechanism”, “integrative medicine”, and “pain management”, and these words were the most highly ranked in terms of burst strength.

Figure 9 Map of the top 7 keywords with the strongest citation bursts.

Note: In this figure, “bold number” represents the start times of the burst.

Reference Co-Citation Analysis

Reference co-citation refers to two (or more) articles that are cited by one or more articles simultaneously, which can be used to assess the degree of correlation among the articles. Furthermore, co-cited references highlight the key articles contributing to research in the field. Figure 10 shows the reference co-citation map consisting of 451 cited references and 1725 co-citation links from 2012 to 2022. Table 10 and Table 11 outline the top 5 most cited references and the highest centrality of acupuncture treatment for cancer pain for the last 10 years, respectively. A cluster analysis of the co-cited references was generated to analyze the common themes in similar articles. Figure 11 shows the 10 clusters of the co-cited references. The five largest clusters were #0 clinical evidence, #1 pilot study, #2 cancer pain, #3 taxane-induced peripheral neuropathy, and #4 pragmatic pilot study.

Figure 10 Co-citation map of references on acupuncture therapy for cancer pain.

Table 10 Top 5 Cited References with the Highest Frequency Values for Acupuncture Treatment for Cancer Pain

Table 11 Top 5 Cited References with the Highest Centrality Values for Acupuncture Treatment for Cancer Pain

Figure 11 Cluster map of co-cited references on acupuncture therapy for cancer pain.

By analyzing the citation burst of references, a total of 21 citations were extracted for this study and are displayed in Figure 12. The most recent burst references from 2020 to the present were in the articles by Van (2016),2 Bao T (2018),54 Fallon M (2018),29 Hershman DL (2018),40 and Bray F (2018).20 Of these, the article published by Hershman DL (2018) had the highest strength value of 7.68.

Figure 12 Map of the top 21 references with the strongest citation bursts.

Note: In this figure, “bold number” represents the start times of the burst.

Discussion General Information

From 2012, with 8 publications, to 2021, with 48 publications, the annual volume of publications showed a steady growth trend with a micro fluctuation for acupuncture therapy for cancer pain. The substantial annual publications that have emerged since 2020 indicate that this topic is in a period of rapid development and augurs well for the future. In terms of the impact factor (IF) of the most frequent journals, the IFs of the top 10 journals ranged from 1.817 to 5.075, and the generally low IFs of high-frequency journals indicated that research on acupuncture treatment for cancer pain needs to be published in high-quality journals to improve influence worldwide.

In terms of the distribution of nations, China, as the birthplace of acupuncture, ranked first with 117 studies, followed by the USA with 96 studies. Studies from China and the USA, accounting for 70% of 302 papers, indicated that the two nations made a substantial contribution to the progress of acupuncture therapy for cancer pain. China and the USA formed their own networks but maintained a weak degree of cooperation with each other. Therefore, academic barriers should be eliminated by researchers and institutions from different nations to seek more cooperation for high-quality and in-depth Research.

In terms of institutions, the USA and Asia (China and South Korea) had the top 5 institutions with a high frequency of studies and values of centrality. Memorial Sloan Kettering Cancer Center, as a level 2 hospital for cancer in America, plays a key role in the research of acupuncture therapy for cancer pain, with the most number of studies (21) and top centrality value (0.1) of the 252 institutions. In addition, all the values of centrality of institutions were less than 0.1 other than Memorial Sloan Kettering Cancer Center, which showed that most institutions are collaborating on a small scale. It is important to strengthen cooperation between institutions to promote the development and dissemination of acupuncture treatment for cancer pain.

In terms of authors, Mao JJ from Memorial Sloan Kettering Cancer Center published the most papers (19) with his partners. Bao Ting, the second ranked author with 10 articles, came from the same organization as Professor Mao. In recent years, Mao JJ’s team has been dedicated to research on acupuncture treatment for cancer. Of these studies, a systematic review and meta-analysis published in 2020 on acupuncture therapy for cancer pain with a high IF of 33.006, which was cited 94 times, has an important influence in this field. In this paper, acupuncture was further proven to reduce cancer pain and decrease the use of analgesics.14 In another review by Mao JJ, the safety of acupuncture therapy was confirmed, and practical tips on how to integrate acupuncture into cancer care were suggested.78 Thanks to the efforts of Professor Mao’s team, the application and spread of acupuncture for cancer pain has been promoted in the United States.

Research Hotspots and Trends

It was believed that research hotspots or emerging trends could be identified via keyword or reference co-occurrence analysis, clusters and bursts in citations over a period of time.

Research Hotspot: Types of Cancer

The common cancer types for acupuncture treatment for cancer pain include breast cancer, lung cancer, gastric cancer, pancreatic cancer, colon cancer and multiple myeloma. Based on the frequency, centrality, clusters, and citation burst of the keywords and references, we can conclude that breast cancer is of great concern in this field. Breast cancer accounts for approximately 30% of female cancers79 and has become the top cancer among women. Breast cancer has a high survival rate after aggressive treatment. However, some side effects that emerge with chemotherapy, surgery, or pharmacological treatment affect the quality of life and even the treatment process. In recent years, some RCTs have verified that acupuncture is effective in alleviating pain in breast cancer, including chemotherapy-induced peripheral neuropathy,59 musculoskeletal symptoms and arthralgia caused by aromatase inhibitors.44 In addition, a feasibility study showed that acupuncture is a feasible option for postoperative breast cancer patients.80 These studies supplied solid evidence on acupuncture for breast cancer pain. A clinical guideline suggested that acupuncture could be considered for the management of pain in breast cancer patients.38

Based on the cluster of keywords, multiple myeloma is probably the hotspot disease of cancer in this field. Multiple myeloma is a hematologic malignancy, with a prevalence of 588,161 people worldwide per year.81 Some studies confirm that acupuncture can decrease peripheral neuropathy in patients with multiple myeloma caused by chemotherapy60 and reduce the use of pain medications in multiple myeloma patients undergoing autologous hematopoietic stem cell transplantation.82

Intervention Techniques

In conformity with the frequency and centrality of the keywords, we conjectured that electroacupuncture may be the most therapeutic technique in this field. Electroacupuncture could exert continuous stimulation on specific acupoints. Electroacupuncture blocks pain by activating a variety of bioactive chemicals through peripheral, spinal, and supraspinal mechanisms.83 A study showed that electroacupuncture attenuates morphine tolerance via inhibiting the PI3K/Akt/JNK1/2 signaling pathway of rats with bone cancer pain.84 Electroacupuncture alleviates paclitaxel-induced peripheral neuropathic pain by suppressing TLR4 signaling and upregulating TRPV1 in dorsal root ganglion neurons of rat.85 A study proved that electroacupuncture decreased the symptoms of fatigue, sleep, and psychological distress in breast cancer patients by alleviating aromatase inhibitor-related arthralgia.43 An RCT showed that electroacupuncture reduced postoperative analgesic requirements of colorectal cancer patients.86

In addition, bee venom acupuncture (BVA), as a new acupuncture treatment, is probably the hotspot in this field according to the cluster of keywords. BVA involves stimulating the acupoint with diluted bee venom, which has been proven effective in osteoarthritis of the knee, rheumatoid arthritis, peripheral neuropathies, pain, stroke and Parkinson’s disease.87,88 Strikingly, BVA has been proven to be effective for neuropathic pain induced by chemotherapy in animal models.89,90

Type of Cancer Pain Postoperative Pain

Based on the clusters of keywords (#2 postoperative pain), postoperative pain is probably the most common type of cancer pain in this field. Surgery is a common therapy for cancer patients, while pain induced by surgery remains a serious problem. A bibliometric analysis of acupuncture for postoperative pain showed that acupuncture is involved in analgesia in lung cancer surgery and gastric cancer surgery.91 An RCT showed that transcutaneous electrical acupoint stimulation could be a feasible approach for sedation and postoperative analgesia in thoracoscopic pulmonary resection.92 A clinical study revealed that transcutaneous electrical acupoint stimulation pretreatment could reduce chronic pain 6 months after mastectomy.93

Peripheral Neuropathic Pain Syndrome

Based on the clusters of references (#3 taxane-induced peripheral neuropathy, #5 chemotherapy-induced peripheral neuropathy), peripheral neuropathic pain is probably the most common type of cancer pain in this field. Some chemotherapy drugs can damage the peripheral nerves, ultimately resulting in chemotherapy-induced peripheral neuropathy (CIPN), which presents severe neuropathic pain syndrome. The severity of the acute syndrome may require reducing the dose of chemotherapy or even ceasing it, with potential impact on tumour control and survival. CIPN can persist for months or year after the cessation of chemotherapy.94,95 Currently, we have no effective preventive and limited treatment options to relieve pain symptoms in CIPN.96

Acupuncture, as a early form and foundation of peripheral stimulation,97,98 provide an alternative or adjunctive therapy for neuropathic pain via increasing the level of spinal or brain 5-hydroxytryptamine (5-HT), norepinephrine (NE), and opioid peptides.99 Acupuncture are beneficial and cost-effective approaches for easing peripheral neuropathic pain and hence can be considered for peripheral neuropathic pain management.100 A study showed that acupuncture resulted in significant improvement in CIPN symptoms compared with usual care.101 An RCT of 104 patients suggested that acupuncture combined with methylcobalamin in the treatment of CIPN in patients with multiple myeloma showed a better outcome than methylcobalamin administration alone.47 A systematic review and meta-analysis of 386 cancer patients revealed that acupuncture could effectively relieve CIPN pain and functional limitation.102

Aromatase Inhibitors-Associated Arthralgia Syndrome

Aromatase inhibitors have radically changed the prognosis of hormone receptor positive breast cancer in post-menopausal women. However, side-effects induced by aromatase inhibitors impact the effect and quality of breast cancer. Among them, Aromatase inhibitors-associated arthralgia syndrome(AIA), which consists of symmetrical joint pain, mainly affecting hands, wrists and knees, and sometimes lower back, hips, shoulders and feet, is one of the leading causes of therapy discontinuation.103 According to the co-cited references analysis, the article published by Dawn L. Hershman (2018)40 and (2013)44 with the most frequency and centrality respectively, which indicated that acupuncture for joint pain induced by aromatase inhibitors in patients with breast cancer has aroused much attention. A systematic review and meta-analysis of 603 breast cancer patients showed that acupuncture is a safe and effective treatment for breast cancer patients with AIA.104

Research Trends and Frontiers

The clusters of keywords, “#5 Randomized controlled trial”, and the high frequency and centrality of keywords indicated that RCTs are an important research method in this topic, and the high frequency and centrality of cited references verified this. Evidence-based evaluation is also a current trend in this topic from the reference co-citation analysis.

According to the newest burst keywords, “mechanism”, with the highest strength value, may be a research trend in acupuncture for cancer pain. To date, research on the mechanism of acupuncture for cancer pain has mainly concentrated on cancer-induced bone pain in rat models. Bone is one of the most common sites for metastasis in cancer, particularly in patients with multiple myeloma, breast, prostate or lung cancer,105,106 and bone pain is one of the most common types of chronic pain in these patients.107 The underlying mechanism of cancer-induced bone pain includes reducing the expression of CXCL12 by inhibiting the activation of NF-κB,108 suppressing the expression of 5-HT and 5-HT3AR, and increasing the expression of MOR and endomorphin-1 in the RVM-spinal cord pathway.109 Recently, animal research revealed mTOR as a potential target in bone cancer pain and electroacupuncture analgesia.110 For better development and application in this field, more experiments need to be conducted to explore the mechanism of acupuncture for cancer pain.

Strengths and Limitations

The strength of this study is that we performed a visual analysis of the literature related to acupuncture treatment for cancer pain and summarized the current research status and research frontiers in this field. However, this study also has certain limitations that need to be addressed. First, due to CiteSpace being unable to analyze cited references for other databases, we only extracted publications from the Web of Science Core Collection, which may lead to publication bias. In addition, with the continuous addition of publications, the findings of this study may have a certain lag.

Conclusion

This study discloses the research status and emerging trends of acupuncture for cancer pain during the past decade from the perspective of bibliometric analysis via CiteSpace. The annual volume of publications suggests that the field of acupuncture therapy for cancer pain has been on the rise. The general quality of research on acupuncture therapy for cancer pain needs to be further improved. More studies without language and academic barriers need to be performed to enhance global cooperation and communications. The current research hotspots concentrate on breast cancer and multiple myeloma, electroacupuncture, bee venom acupuncture, postoperative pain, peripheral neuropathic pain syndrome, and aromatase inhibitors-associated arthralgia syndrome. The research trends and frontiers include clinical trials, evidence-based evaluations and the mechanism of acupuncture for cancer pain. Furthermore, more rigorous clinical trials and more research exploring related mechanisms are needed in the future.

Abbreviations

RCT, randomized controlled trial; WoS, Web of Science; IF, impact factor; CIPN, chemotherapy-induced peripheral neuropathy; BVA, bee venom acupuncture; AIA, Aromatase inhibitors-associated arthralgia syndrome.

Data Sharing Statement

The raw data of this article can be obtained by contacting FL, XL, and WQ directly.

Acknowledgments

The authors express their appreciation for Prof. Chaomei Chen, who developed CiteSpace and allowed us to access it.

Author Contributions

All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work.

Funding

This study was supported by the National Natural Science Foundation of China (No. U21A20404) and the General Program of the National Natural Science Foundation of China (No. 82074556).

Disclosure

The authors report no conflicts of interest in this work.

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