Design, synthesis, and mechanism of action of novel μ-conotoxin KIIIA analogues for inhibition of the voltage-gated sodium channel Nav1.7
Keywords
μ-conotoxin
voltage-gated sodium ion channel
analgesia
structure optimization
peptide synthesis
KIIIA
AbbreviationsDab
L-2,4-diaminobutyric acid
Dapa
L-2,3-diaminopropionic acid
DIPEA
N,N′-diisopropylethylamine
Fmoc
9-fluorenylmethoxycarbonyl
HCTU
5-chloro-1-[bis(dimethylamino)methylene]-1H-benzotriazolium 3-oxide hexafluorophosphate
Nav
voltage-gated sodium channel
RP-HPLC
reversed-phase high-performance liquid chromatography
TTX-r
Tetrodotoxin-resistant
© 2023 THE AUTHORS. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.
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