Heilig, M., Epstein, D. H., Nader, M. A. & Shaham, Y. Time to connect: bringing social context into addiction neuroscience. Nat. Rev. Neurosci. 17, 592–599 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vanderschuren, L. J., Achterberg, E. J. & Trezza, V. The neurobiology of social play and its rewarding value in rats. Neurosci. Biobehav. Rev. 70, 86–105 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Yizhar, O. & Levy, D. R. The social dilemma: prefrontal control of mammalian sociability. Curr. Opin. Neurobiol. 68, 67–75 (2021).

Article  CAS  PubMed  Google Scholar 

Venniro, M., Banks, M. L., Heilig, M., Epstein, D. H. & Shaham, Y. Improving translation of animal models of addiction and relapse by reverse translation. Nat. Rev. Neurosci. 21, 625–643 (2020).

Article  CAS  PubMed  Google Scholar 

Venniro, M., Russell, T. I., Zhang, M. & Shaham, Y. Operant social reward decreases incubation of heroin craving in male and female rats. Biol. Psychiatry 86, 848–856 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Venniro, M. & Shaham, Y. An operant social self-administration and choice model in rats. Nat. Protoc. 15, 1542–1559 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Venniro, M. et al. Volitional social interaction prevents drug addiction in rat models. Nat. Neurosci. 21, 1520–1529 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Venniro, M., Panlilio, L. V., Epstein, D. H. & Shaham, Y. The protective effect of operant social reward on cocaine self-administration, choice, and relapse is dependent on delay and effort for the social reward. Neuropsychopharmacology https://doi.org/10.1038/s41386-021-01148-6 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Venniro, M. et al. Abstinence-dependent dissociable central amygdala microcircuits control drug craving. Proc. Natl Acad. Sci. USA 117, 8126–8134 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ellenbroek, B. & Youn, J. Rodent models in neuroscience research: is it a rat race? Dis. Model Mech. 9, 1079–1087 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dolen, G., Darvishzadeh, A., Huang, K. W. & Malenka, R. C. Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin. Nature 501, 179–184 (2013).

Article  PubMed  PubMed Central  Google Scholar 

Felix-Ortiz, A. C. & Tye, K. M. Amygdala inputs to the ventral hippocampus bidirectionally modulate social behavior. J. Neurosci. 34, 586–595 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gunaydin, L. A. et al. Natural neural projection dynamics underlying social behavior. Cell 157, 1535–1551 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Levy, D. R. et al. Dynamics of social representation in the mouse prefrontal cortex. Nat. Neurosci. 22, 2013–2022 (2019).

Article  CAS  PubMed  Google Scholar 

Nardou, R. et al. Oxytocin-dependent reopening of a social reward learning critical period with MDMA. Nature 569, 116–120 (2019).

Article  CAS  PubMed  Google Scholar 

Wei, D. et al. Endocannabinoid signaling mediates oxytocin-driven social reward. Proc. Natl Acad. Sci. USA 112, 14084–14089 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yizhar, O. et al. Neocortical excitation/inhibition balance in information processing and social dysfunction. Nature 477, 171–178 (2011).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Netser, S. et al. Distinct dynamics of social motivation drive differential social behavior in laboratory rat and mouse strains. Nat. Commun. 11, 5908 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Poole, T. B. & Fish, J. An investigation of playful behaviour in Rattus norvegicus and Mus musculus (Mammalia). J. Zool. Soc. Lond. 175, 61–71 (1975).

Article  Google Scholar 

Trezza, V., Campolongo, P. & Vanderschuren, L. J. Evaluating the rewarding nature of social interactions in laboratory animals. Dev. Cogn. Neurosci. 1, 444–458 (2011).

Article  PubMed  PubMed Central  Google Scholar 

Hu, R. K. et al. An amygdala-to-hypothalamus circuit for social reward. Nat. Neurosci. https://doi.org/10.1038/s41593-021-00828-2 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Martin, L. & Iceberg, E. Quantifying social motivation in mice using operant conditioning. J. Vis. Exp. https://doi.org/10.3791/53009 (2015).

Brodkin, E. S., Hagemann, A., Nemetski, S. M. & Silver, L. M. Social approach-avoidance behavior of inbred mouse strains towards DBA/2 mice. Brain Res. 1002, 151–157 (2004).

Article  CAS  PubMed  Google Scholar 

Panksepp, J. B. et al. Affiliative behavior, ultrasonic communication and social reward are influenced by genetic variation in adolescent mice. PLoS ONE 2, e351 (2007).

Article  PubMed  PubMed Central  Google Scholar 

Panksepp, J. B. & Lahvis, G. P. Social reward among juvenile mice. Genes Brain Behav. 6, 661–671 (2007).

Article  CAS  PubMed  Google Scholar 

Golden, S. A. et al. Compulsive addiction-like aggressive behavior in mice. Biol. Psychiatry 82, 239–248 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Golden, S. A. et al. Nucleus accumbens Drd1-expressing neurons control aggression self-administration and aggression seeking in mice. J. Neurosci. 39, 2482–2496 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aleyasin, H. et al. Cell-type-specific role of DeltaFosB in nucleus accumbens in modulating intermale aggression. J. Neurosci. 38, 5913–5924 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ramsey, L. A., Holloman, F. M., Hope, B. T., Shaham, Y. & Venniro, M. Waving through the window: A model of volitional social interaction in female mice. Biol. Psychiatry https://doi.org/10.1016/j.biopsych.2021.10.023 (2022).

Miczek, K. A., Maxson, S. C., Fish, E. W. & Faccidomo, S. Aggressive behavioral phenotypes in mice. Behav. Brain Res. 125, 167–181 (2001).

Article  CAS  PubMed  Google Scholar 

Cann, C., Venniro, M., Hope, B. T. & Ramsey, L. A. Parametric investigation of social place preference in adolescent mice. Behav. Neurosci. 134, 435–443 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kummer, K. K. et al. Differences in social interaction- vs. cocaine reward in mouse vs. rat. Front. Behav. Neurosci. 8, 363 (2014).

Article  PubMed  PubMed Central  Google Scholar 

Pierce, R. C., Crawford, C. A., Nonneman, A. J., Mattingly, B. A. & Bardo, M. T. Effect of forebrain dopamine depletion on novelty-induced place preference behavior in rats. Pharmacol. Biochem. Behav. 36, 321–325 (1990).

Article  CAS  PubMed  Google Scholar 

Joel, D. & McCarthy, M. M. Incorporating sex as a biological variable in neuropsychiatric research: where are we now and where should we be? Neuropsychopharmacology 42, 379–385 (2017).

Article  PubMed  Google Scholar 

Beery, A. K. & Zucker, I. Sex bias in neuroscience and biomedical research. Neurosci. Biobehav. Rev. 35, 565–572 (2011).

Article  PubMed  Google Scholar 

Hughes, R. N. Sex does matter: comments on the prevalence of male-only investigations of drug effects on rodent behaviour. Behav. Pharmacol. 18, 583–589 (2007).

Article  PubMed  Google Scholar 

Golden, S. A. & Shaham, Y. Aggression addiction and relapse: a new frontier in psychiatry. Neuropsychopharmacology 43, 224–225 (2018).

Article  PubMed  Google Scholar 

Richardson, N. R. & Roberts, D. C. Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy. J. Neurosci. Methods 66, 1–11 (1996).

Article  CAS  PubMed