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Research Article
Kounoue N. · Oguchi H. · Tochigi N. · Mikami T. · Yamaguchi Y. · Honda K. · Yonekura T. · Muramatsu M. · Itabashi Y. · Sakai K.
Introduction: Multinucleated polyploidization (MNP) of tubular epithelial cells is occasionally observed in kidney allografts. The present study aimed to clarify the clinical and pathological significance of MNP of tubular epithelial cells in kidney allografts. Methods: Fifty-eight 1-year biopsies from 58 patients who underwent kidney transplantation at our hospital from January 2016 to December 2017 were included. MNP was counted in each specimen, and the specimens were divided into two groups by the median value. The differences in clinical and pathological characteristics were compared. Ki67-positive cells were counted among tubular epithelial cells to explore the association between cell cycle and MNP. In an additional cohort, MNP was compared between biopsies after precedent T-cell-mediated rejection and precedent medullary ray injury. Results: The 58 cases were divided into two groups by the median total amount of MNP: Group A (MNP ≥3) and Group B (MNP
The Author(s). Published by S. Karger AG, Basel
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