Verkhratsky A, Nedergaard M (2018) Physiology of Astroglia. Physiol Rev 98:239–389. https://doi.org/10.1152/physrev.00042.2016
Article CAS PubMed Google Scholar
Escartin C, Galea E, Lakatos A et al (2021) Reactive astrocyte nomenclature, definitions, and future directions. Nat Neurosci. https://doi.org/10.1038/s41593-020-00783-4
Article PubMed PubMed Central Google Scholar
Mathern GW, Babb TL, Vickrey BG et al (1995) The clinical-pathogenic mechanisms of hippocampal neuron loss and surgical outcomes in temporal lobe epilepsy. Brain 118:105–118. https://doi.org/10.1093/brain/118.1.105
Clossen BL, Reddy DS (2017) Novel therapeutic approaches for disease-modification of epileptogenesis for curing epilepsy. Biochim Biophys Acta BBA - Mol Basis Dis 1863:1519–1538. https://doi.org/10.1016/j.bbadis.2017.02.003
Löscher W, Schmidt D (2011) Modern antiepileptic drug development has failed to deliver: ways out of the current dilemma. Epilepsia 52:657–678. https://doi.org/10.1111/j.1528-1167.2011.03024.x
Bedner P, Dupper A, Hüttmann K et al (2015) Astrocyte uncoupling as a cause of human temporal lobe epilepsy. Brain 138:1208–1222. https://doi.org/10.1093/brain/awv067
Article PubMed PubMed Central Google Scholar
Rusina E, Bernard C, Williamson A (2021) The Kainic Acid Models of Temporal Lobe Epilepsy. https://doi.org/10.1523/ENEURO.0337-20.2021. eNeuro 8:
Jefferys J, Steinhäuser C, Bedner P (2016) Chemically-induced TLE models: Topical application. J Neurosci Methods 260:53–61. https://doi.org/10.1016/j.jneumeth.2015.04.011
Article CAS PubMed Google Scholar
Bedner P, Jabs R, Steinhäuser C (2020) Properties of human astrocytes and NG2 glia. Glia 68:756–767. https://doi.org/10.1002/glia.23725
Orkand RK (1986) Introductory Remarks: Glial-Interstitial Fluid Exchange. Ann N Y Acad Sci 481:269–272. https://doi.org/10.1111/j.1749-6632.1986.tb27157.x
Article CAS PubMed Google Scholar
Heinemann U, Gabriel S, Jauch R et al (2000) Alterations of Glial Cell Function in Temporal Lobe Epilepsy. Epilepsia 41:S185–S189. https://doi.org/10.1111/j.1528-1157.2000.tb01579.x
Jauch R, Windmüller O, Lehmann T-N et al (2002) Effects of barium, furosemide, ouabaine and 4,4′-diisothiocyanatostilbene-2,2′-disulfonic acid (DIDS) on ionophoretically-induced changes in extracellular potassium concentration in hippocampal slices from rats and from patients with epilepsy. Brain Res 925:18–27. https://doi.org/10.1016/S0006-8993(01)03254-1
Article CAS PubMed Google Scholar
Kivi A, Lehmann T-N, Kovács R et al (2000) Effects of barium on stimulus-induced rises of [K+]o in human epileptic non-sclerotic and sclerotic hippocampal area CA1. Eur J Neurosci 12:2039–2048. https://doi.org/10.1046/j.1460-9568.2000.00103.x
Article CAS PubMed Google Scholar
Hinterkeuser S, Schröder W, Hager G et al (2000) Astrocytes in the hippocampus of patients with temporal lobe epilepsy display changes in potassium conductances. Eur J Neurosci 12:2087–2096. https://doi.org/10.1046/j.1460-9568.2000.00104.x
Article CAS PubMed Google Scholar
Schröder W, Hinterkeuser S, Seifert G et al (2000) Functional and molecular properties of human astrocytes in acute hippocampal slices obtained from patients with temporal lobe epilepsy. Epilepsia 41(Suppl 6):S181–184
Bordey A, Sontheimer H (1998) Electrophysiological Properties of Human Astrocytic Tumor Cells In Situ: Enigma of Spiking Glial Cells. J Neurophysiol 79:2782–2793. https://doi.org/10.1152/jn.1998.79.5.2782
Article CAS PubMed Google Scholar
Heuser K, Eid T, Lauritzen F et al (2012) Loss of Perivascular Kir4.1 Potassium Channels in the Sclerotic Hippocampus of Patients With Mesial Temporal Lobe Epilepsy. J Neuropathol Exp Neurol 71:814–825. https://doi.org/10.1097/NEN.0b013e318267b5af
Article CAS PubMed Google Scholar
Kitaura H, Shirozu H, Masuda H et al (2018) Pathophysiological Characteristics Associated With Epileptogenesis in Human Hippocampal Sclerosis. EBioMedicine 29:38–46. https://doi.org/10.1016/j.ebiom.2018.02.013
Article PubMed PubMed Central Google Scholar
Das A, Wallace GC, Holmes C et al (2012) Hippocampal tissue of patients with refractory temporal lobe epilepsy is associated with astrocyte activation, inflammation, and altered expression of channels and receptors. Neuroscience 220:237–246. https://doi.org/10.1016/j.neuroscience.2012.06.002
Article CAS PubMed Google Scholar
Buono RJ, Lohoff FW, Sander T et al (2004) Association between variation in the human KCNJ10 potassium ion channel gene and seizure susceptibility. Epilepsy Res 58:175–183. https://doi.org/10.1016/j.eplepsyres.2004.02.003
Article CAS PubMed Google Scholar
Heuser K, Nagelhus EA, Taubøll E et al (2010) Variants of the genes encoding AQP4 and Kir4.1 are associated with subgroups of patients with temporal lobe epilepsy. Epilepsy Res 88:55–64. https://doi.org/10.1016/j.eplepsyres.2009.09.023
Article CAS PubMed Google Scholar
Chever O, Djukic B, McCarthy KD, Amzica F (2010) Implication of Kir4.1 Channel in Excess Potassium Clearance: An In Vivo Study on Anesthetized Glial-Conditional Kir4.1 Knock-Out Mice. J Neurosci 30:15769–15777. https://doi.org/10.1523/JNEUROSCI.2078-10.2010
Article CAS PubMed PubMed Central Google Scholar
Haj-Yasein NN, Jensen V, Vindedal GF et al (2011) Evidence that compromised K + spatial buffering contributes to the epileptogenic effect of mutations in the human kir4.1 gene (KCNJ10). Glia 59:1635–1642. https://doi.org/10.1002/glia.21205
David Y, Cacheaux LP, Ivens S et al (2009) Astrocytic Dysfunction in Epileptogenesis: Consequence of Altered Potassium and Glutamate Homeostasis? J Neurosci 29:10588–10599. https://doi.org/10.1523/JNEUROSCI.2323-09.2009
Article CAS PubMed PubMed Central Google Scholar
Takahashi DK, Vargas JR, Wilcox KS (2010) Increased coupling and altered glutamate transport currents in astrocytes following kainic-acid-induced status epilepticus. Neurobiol Dis 40:573–585. https://doi.org/10.1016/j.nbd.2010.07.018
Article CAS PubMed PubMed Central Google Scholar
Deshpande T, Li T, Herde MK et al (2017) Subcellular reorganization and altered phosphorylation of the astrocytic gap junction protein connexin43 in human and experimental temporal lobe epilepsy. Glia 65:1809–1820. https://doi.org/10.1002/glia.23196
Loddenkemper T, Grote K, Evers S et al (2002) Neurological manifestations of the oculodentodigital dysplasia syndrome. J Neurol 249:584–595. https://doi.org/10.1007/s004150200068
Walrave L, Vinken M, Leybaert L, Smolders I (2020) Astrocytic Connexin43 Channels as Candidate Targets in Epilepsy Treatment. Biomolecules 10:1578. https://doi.org/10.3390/biom10111578
Article CAS PubMed PubMed Central Google Scholar
Breithausen B, Kautzmann S, Boehlen A et al (2020) Limited contribution of astroglial gap junction coupling to buffering of extracellular K + in CA1 stratum radiatum. Glia 68:918–931. https://doi.org/10.1002/glia.23751
Pannasch U, Vargová L, Reingruber J et al (2011) Astroglial networks scale synaptic activity and plasticity. Proc Natl Acad Sci U S A 108:8467–8472. https://doi.org/10.1073/pnas.1016650108
Article PubMed PubMed Central Google Scholar
Wallraff A, Köhling R, Heinemann U et al (2006) The Impact of Astrocytic Gap Junctional Coupling on Potassium Buffering in the Hippocampus. J Neurosci 26:5438–5447. https://doi.org/10.1523/JNEUROSCI.0037-06.2006
Article CAS PubMed PubMed Central Google Scholar
Bazzigaluppi P, Weisspapir I, Stefanovic B et al (2017) Astrocytic gap junction blockade markedly increases extracellular potassium without causing seizures in the mouse neocortex. Neurobiol Dis 101:1–7. https://doi.org/10.1016/j.nbd.2016.12.017
Article CAS PubMed Google Scholar
EbrahimAmini A, Bazzigaluppi P, Aquilino MS et al (2021) Neocortical in vivo focal and spreading potassium responses and the influence of astrocytic gap junctional coupling. Neurobiol Dis 147:105160. https://doi.org/10.1016/j.nbd.2020.105160
Article CAS PubMed Google Scholar
Deshpande T, Li T, Henning L et al (2020) Constitutive deletion of astrocytic connexins aggravates kainate-induced epilepsy. Glia 68:2136–2147. https://doi.org/10.1002/glia.23832
Chever O, Dossi E, Pannasch U et al (2016) Astroglial networks promote neuronal coordination. Sci Signal 9:ra6–ra6. https://doi.org/10.1126/scisignal.aad3066
Article CAS PubMed Google Scholar
Hösli L, Binini N, Ferrari KD et al (2022) Decoupling astrocytes in adult mice impairs synaptic plasticity and spatial learning. Cell Rep 38:110484. https://doi.org/10.1016/j.celrep.2022.110484
Article CAS PubMed Google Scholar
Löscher W, Friedman A (2020) Structural, Molecular, and Functional Alterations of the Blood-Brain Barrier during Epileptogenesis and Epilepsy: A Cause, Consequence, or Both? Int J Mol Sci 21:591. https://doi.org/10.3390/ijms21020591
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