Suppressing NLRP3 activation and PI3K/AKT/mTOR signaling ameliorates amiodarone-induced pulmonary fibrosis in rats: a possible protective role of nobiletin

Al-Shammari B, Khalifa M, Bakheet SA, Yasser M (2016) A mechanistic study on the amiodarone-induced pulmonary toxicity. Oxid Med Cell Longev 2016:1–16

Article  Google Scholar 

Arifin WN, Zahiruddin WM (2017) Sample size calculation in animal studies using resource equation approach. Malays J Med Sci MJMS 24(5):101–105

PubMed  Google Scholar 

Bahri S, Ali RB, Abidi A, Jameleddine S (2017) The efficacy of plant extract and bioactive compounds approaches in the treatment of pulmonary fibrosis: a systematic review. Biomed Pharmacother 93:666–673

Article  CAS  PubMed  Google Scholar 

Bancroft JD, Gamble M (2008) Theory and practice of histological techniques, 6th edn. Churchill Livingstone, Elsevier

Google Scholar 

Bunbupha S, Apaijit K, Maneesai P, Prasarttong P, Pakdeechote P (2020) Nobiletin ameliorates high-fat diet-induced vascular and renal changes by reducing inflammation with modulating Adipor1 and TGF-β1 expression in rats. Life Sci 260:118398

Article  CAS  PubMed  Google Scholar 

Chen Z, Zhong H, Wei J, Lin S, Zong Z, Gong F, Huang X, Sun J, Li P, Lin H, Wei Bo, Chu J (2019) Inhibition of Nrf2/HO-1 signaling leads to increased activation of the NLRP3 inflammasome in osteoarthritis. Arthritis Res Ther 21(1):300

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cuello AC (1993) Immunohistochemistry II. Wiley Press, NY

Google Scholar 

Ding S, Wang H, Wang M, Bai L, Pengxin Yu, Weidong Wu (2019) Resveratrol alleviates chronic ‘real-world’ ambient particulate matter-induced lung inflammation and fibrosis by inhibiting NLRP3 inflammasome activation in mice. Ecotoxicol Environ Saf 182:109425

Article  CAS  PubMed  Google Scholar 

dos Santos G, Kutuzov MA, Ridge KM (2012) The inflammasome in lung diseases. Am J Physiol Lung Cell Mol Physiol 303(8):627–633

Article  Google Scholar 

Festing MF, Altman DG (2002) Guidelines for the design and statistical analysis of experiments using laboratory animals. ILAR J 43(4):244–257

Article  CAS  PubMed  Google Scholar 

Garon EB, Yang J-H, Dubinett SM (2020) The role of interleukin 1β in the pathogenesis of lung cancer. JTO Clin Res Rep 1(1):100001

PubMed  PubMed Central  Google Scholar 

Güvenç M, Cellat M, Gökçek İ, Özkan H, Arkalı G, Yakan A, Özsoy ŞY, Aksakal M (2020) Nobiletin attenuates acetaminophen-induced hepatorenal toxicity in rats. J Biochem Mol Toxicol 34(2):e22427

Article  PubMed  Google Scholar 

Hagenlocher Y, Gommeringer S, Held A, Feilhauer K, Köninger J, Bischoff SC, Lorentz A (2019) Nobiletin acts anti-inflammatory on murine IL-10−/− colitis and human intestinal fibroblasts. Eur J Nutr 58(4):1391–1401

Article  CAS  PubMed  Google Scholar 

Han B, Chu C, Su X, Zhang N, Zhou L, Zhang M, Yang S, Shi L, Zhao B, Niu Y, Zhang R (2019) N6-methyladenosine-dependent primary microRNA-126 processing activated PI3K-AKT-MTOR pathway drove the development of pulmonary fibrosis induced by nanoscale carbon black particles in rats. Naotoxicology 14(1):1–20. https://doi.org/10.1080/17435390.2019.1661041

Article  CAS  Google Scholar 

Huang H, Li L, Shi W, Liu H, Yang J, Yuan X, Wu L (2016) The multifunctional effects of nobiletin and its metabolites in vivo and in vitro” edited by I.-M. Chang. Evid-Based Complement Altern Med. 2016:2918796

Article  Google Scholar 

Ibrahim Fouad G, Mousa MR (2021) The protective potential of alpha lipoic acid on amiodarone-induced pulmonary fibrosis and hepatic injury in rats. Mol Cell Biochem 476(9):3433–3448

Article  CAS  PubMed  Google Scholar 

Ji J, Hou J, Xia Y, Xiang Z, Han X (2021) NLRP3 inflammasome activation in alveolar epithelial cells promotes myofibroblast differentiation of lung-resident mesenchymal stem cells during pulmonary fibrogenesis. Biochim Biophys Acta (BBA) Mol Basis Dis 1867(5):166077

Article  CAS  Google Scholar 

Joshi H, Almgren-Bell A, Anaya EP, Todd EM, Van Dyken SJ, Seth A, McIntire KM, Singamaneni S, Sutterwala F, Morley SC (2022) L-plastin enhances NLRP3 inflammasome assembly and bleomycin-induced lung fibrosis. Cell Rep 38(11):110507

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kato R, Ijiri Y, Hayashi T (2021) Amiodarone, unlike dronedarone, activates inflammasomes via its reactive metabolites: implications for amiodarone adverse reactions. Chem Res Toxicol 34(8):1860–1865

Article  CAS  PubMed  Google Scholar 

Kim DY, Kang Y-H, Kang M-K (2020) Dietary nobiletin suppresses TGF-Β1-Src-caveolin-1 dependent signaling involved with high glucose-induced renal mesangial matrix accumulation. J Nutr Health 53(1):1–12

Article  CAS  Google Scholar 

Kolettis TM, Agelaki MG, Baltogiannis GG, Vlahos AP, Mourouzis I, Fotopoulos A, Pantos C (2007) Comparative effects of acute vs. chronic oral amiodarone treatment during acute myocardial infarction in rats. EP Europace 9(11):1099–1104

Article  Google Scholar 

Koracevic D, Koracevic G, Djordjevic V, Andrejevic S, Cosic V (2001) Method for the measurement of antioxidant activity in human fluids. J Clin Pathol 54(5):356–361

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lappalainen U, Whitsett JA, Wert SE, Tichelaar JW, Bry K (2012) Interleukin-1β causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lung. Am J Respir Cell Mol Biol 32(4):311–318. https://doi.org/10.1165/Rcmb.2004-0309OC

Article  Google Scholar 

Lawrence J, Nho R (2018) The role of the mammalian target of rapamycin (MTOR) in pulmonary fibrosis. Int J Mol Sci 19(3):778

Article  PubMed  PubMed Central  Google Scholar 

Li N, Zhang Z, Jiang G, Sun H, Deming Yu (2019) Nobiletin sensitizes colorectal cancer cells to oxaliplatin by PI3K/Akt/MTOR pathway. Front Biosci (landmark Edit) 24(2):303–312

Article  Google Scholar 

Li S, Li X, Chen F, Liu M, Ning L, Yan Y, Shang Z, Huang S, Tu C (2021) Nobiletin mitigates hepatocytes death, liver inflammation, and fibrosis in a murine model of NASH through modulating hepatic oxidative stress and mitochondrial dysfunction. J Nutr Biochem 100:108888

Article  PubMed  Google Scholar 

Loboda A, Damulewicz M, Pyza E, Jozkowicz A, Dulak J (2016) Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism. Cell Mol Life Sci CMLS 73(17):3221–3247

Article  CAS  PubMed  Google Scholar 

Lu Y, Zhang C, Bucheli P, Wei D (2006) Citrus flavonoids in fruit and traditional Chinese medicinal food ingredients in China. Plant Foods Hum Nutr 61(2):57–65

Article  CAS  PubMed  Google Scholar 

Ma W, Shi H, Wei G, Hua M, Ma J, Cui J, Honggang Yu (2020) Loureirin B attenuates amiodarone-induced pulmonary fibrosis by suppression of TGFβ1/Smad2/3 pathway. Trop J Pharm Res 19(7):1371–1376

Article  CAS  Google Scholar 

Mankikian J, Favelle O, Guillon A, Guilleminault L, Cormier B, Jonville-Béra AP, Perrotin D, Diot P, Marchand-Adam S (2014) Initial characteristics and outcome of hospitalized patients with amiodarone pulmonary toxicity. Respir Med 108(4):638–646

Article  CAS  PubMed  Google Scholar 

Nacca N, Bhamidipati CM, Yuhico LS, Pinnamaneni S, Szombathy T (2012) Severe amiodarone induced pulmonary toxicity. J Thorac Dis 4(6):667

CAS  PubMed  PubMed Central  Google Scholar 

Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95(2):351–358

Article  CAS  PubMed  Google Scholar 

Peng Z, Li X, Xing D, Xiliang Du, Wang Z, Liu G, Li X (2018) Nobiletin alleviates palmitic acid-induced NLRP3 inflammasome activation in a Sirtuin 1-dependent manner in AML-12 cells. Mol Med Rep 18(6):5815–5822

CAS  PubMed  Google Scholar 

Peng L, Wen Li, Shi Q-F, Gao F, Huang B, Meng J, Cheng-Ping Hu, Wang C-M (2020) Scutellarin ameliorates pulmonary fibrosis through inhibiting NF-ΚB/NLRP3-mediated epithelial-mesenchymal transition and inflammation. Cell Death Dis 11(11):978

Article  PubMed  PubMed Central  Google Scholar 

Radwan SM, Ghoneim D, Salem M, Saeed M, Saleh Y, Elhamy M, Wael K, Shokair O, Wahdan SA (2020) Adipose tissue-derived mesenchymal stem cells protect against amiodarone-induced lung injury in rats. Appl Biochem Biotechnol 191:1–15

Article  Google Scholar 

Samiei F, Jamshidzadeh A, Noorafshan A, Ghaderi A (2016) Human placental extract ameliorates structural lung changes induced by amiodarone in rats. Iran J Pharm Res IJPR 15(Suppl):75

PubMed  Google Scholar 

Terzo F, Ricci A, D’Ascanio M, Raffa S, Mariotta S (2020) Amiodarone-induced pulmonary toxicity with an excellent response to treatment: a case report. Respir Med Case Rep 29:100974

PubMed  Google Scholar 

Tian R, Zhu Y, Yao J, Meng X, Wang J, Xie H, Wang R (2017) NLRP3 participates in the regulation of EMT in bleomycin-induced pulmonary fibrosis. Exp Cell Res 357(2):328–334

Article  CAS  PubMed  Google Scholar 

Vallée A, Lecarpentier Y (2019) TGF-β in fibrosis by acting as a conductor for contractile properties of myofibroblasts. Cell Biosci 9(1):1–15

Article  Google Scholar 

Wang H, Guo Y, Qiao Yi, Zhang J, Jiang P (2020a) Nobiletin ameliorates NLRP3 inflammasome-mediated inflammation through promoting autophagy via the AMPK pathway. Mol Neurobiol 57(12):5056–5068

Article  CAS  PubMed  Google Scholar 

Wang Z, Zhang S, Xiao Y, Zhang W, Shuai Wu, Qin T, Yue Y, Qian W, Li Li (2020b) NLRP3 inflammasome and inflammatory diseases. Oxid Med Cell Longev 2020:4063562

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