Bernstein CN, et al. World gastroenterology organisation global guidelines inflammatory bowel disease: update august 2015. J Clin Gastroenterol. 2016;50(10):803–18.
Denson LA, et al. Challenges in IBD research: precision medicine. Inflamm Bowel Dis. 2019;25(Suppl 2):S31–9.
Tabib NSS, et al. Big data in IBD: big progress for clinical practice. Gut. 2020;69(8):1520–32.
Alatab S, et al. The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Gastroenterol Hepatol. 2020;5(1):17–30.
Feuerstein JD, Cheifetz AS. Ulcerative colitis: epidemiology, diagnosis, and management. Mayo Clin Proc. 2014;89(11):1553–63.
Feuerstein JD, Cheifetz AS. Crohn disease: epidemiology, diagnosis, and management. Mayo Clin Proc. 2017;92(7):1088–103.
Article CAS PubMed Google Scholar
Dignass A, et al. Living with ulcerative colitis in Germany: a retrospective analysis of dose escalation, concomitant treatment use and healthcare costs. J Med Econ. 2020;23(4):415–27.
da Silva BC, et al. Epidemiology, demographic characteristics and prognostic predictors of ulcerative colitis. World J Gastroenterol. 2014;20(28):9458–67.
Article PubMed PubMed Central Google Scholar
Crohn's & Colitis Foundation of America. The facts about Inflammatory Bowel Diseases. 2014.
Cohen R, et al. Direct and indirect healthcare resource utilization and costs associated with ulcerative colitis in a privately-insured employed population in the US. J Med Econ. 2015;18(6):447–56.
Ananthakrishnan AN, Kaplan GG, Ng SC. Changing global epidemiology of inflammatory bowel diseases: sustaining health care delivery into the 21st century. Clin Gastroenterol Hepatol. 2020;18(6):1252–60.
Matos R, et al. Quality of life in patients with inflammatory bowel disease: the role of positive psychological factors. Health Psychol Behav Med. 2021;9(1):989–1005.
Article PubMed PubMed Central Google Scholar
Mayo Clinic. Crohn's disease. 2020 [cited 2022 February 15]; Available from: https://www.mayoclinic.org/diseases-conditions/crohns-disease/symptoms-causes/syc-20353304
Cleveland Clinic. Ulcerative Colitis. 2020 [cited 2022 February 15]; Available from: https://my.clevelandclinic.org/health/diseases/10351-ulcerative-colitis
Click B, Binion DG, Anderson AM. Predicting costs of care for patients with inflammatory bowel diseases. Clin Gastroenterol Hepatol. 2017;15(3):393–5.
Annese V, et al. Optimizing biologic therapy in inflammatory bowel disease: a Delphi consensus in the United Arab Emirates. Therap Adv Gastroenterol. 2021;14:17562848211065328.
Article CAS PubMed PubMed Central Google Scholar
Ehrenberg R., et al. Dose escalation assessment among targeted immunomodulators in the management of inflammatory bowel disease. J Manag Care Spec Pharm. 2020;26(6): 758–765
van der Valk ME, et al. Healthcare costs of inflammatory bowel disease have shifted from hospitalisation and surgery towards anti-TNFalpha therapy: results from the COIN study. Gut. 2014;63(1):72–9.
Lichtenstein, GR, et al. Lifetime economic burden of Crohn's disease and ulcerative colitis by age at diagnosis. Clin Gastroenterol Hepatol. 2020;18(4): 889–897 e10.
Gibson TB, et al. The direct and indirect cost burden of Crohn’s disease and ulcerative colitis. J Occup Environ Med. 2008;50(11):1261–2122.
Rubin DT, et al. Real-world assessment of therapy changes, suboptimal treatment and associated costs in patients with ulcerative colitis or Crohn’s disease. Aliment Pharmacol Ther. 2014;39(10):1143–55.
Article CAS PubMed Google Scholar
Long MD, et al. Retrospective database analysis: dose escalation and adherence in patients initiating biologics for ulcerative colitis. Dig Dis. 2021;40(5):553–64.
Guberna L., et al. Frequency and effectiveness of empirical anti-tnf dose intensification in inflammatory bowel disease: systematic review with meta-analysis. J Clin Med, 2021. 10(10).
Khan S, et al. Real-world evidence on adherence, persistence, switching and dose escalation with biologics in adult inflammatory bowel disease in the United States: a systematic review. J Clin Pharm Ther. 2019;44(4):495–507.
Zittan E, Gralnek IM, Berns MS. The new proactive approach and precision medicine in Crohn's disease. Biomedicines. 2020;8(7).
Sanchez-Hernandez JG, et al. A 3-year prospective study of a multidisciplinary early proactive therapeutic drug monitoring programme of infliximab treatments in inflammatory bowel disease. Br J Clin Pharmacol. 2020;86(6):1165–75.
Article CAS PubMed PubMed Central Google Scholar
Ma C, et al. Ustekinumab effective for maintaining clinical response in refractory moderate-to-severe Crohn’s disease: a multicentre cohort study [abstract]. In: Journal of the Canadian Association of Gastroenterology. Oxford University Press; 2018. p. 182–4.
Eberl A, et al. Ustekinumab for Crohn’s disease: a nationwide real-life cohort study from Finland (FINUSTE). Scand J Gastroenterol. 2019;54(6):718–25.
Article CAS PubMed Google Scholar
Yadav A, et al. Dose escalation (Q4) of ustekinumab should be considered for Crohn's disease patients who fail standard dosing [abstract]. In: Inflammatory bowel diseases. 2020, Crohn’s & Colitis Foundation and the AGA Institute. p. S72–S73.
Battat R, et al. Association between ustekinumab trough concentrations and clinical, biomarker, and endoscopic outcomes in patients with Crohn's disease. Clin Gastroenterol Hepatol. 2017; 15(9): 1427–1434 e2.
Heron V, et al. Ustekinumab therapeutic drug monitoring in Crohn’s disease patients with loss of response. J Crohns Colitis. 2019;13:S379–80.
Olmedo-Martín R, et al. Effectiveness of ustekinumab dose escalation in Crohn’s disease patients with insufficient response to standard-dose subcutaneous maintenance therapy: an observational multicentre study. J Crohns Colitis. 2021;15:S467–8.
Mateos B, et al. Ustekinumab levels correlate with induction fecal calprotectin drop-slope and discriminate the need for intensification at week 52 in Crohn’s Disease patients. J Crohns Colitis. 2021;15:S533–4.
Ma C, et al. Long-term maintenance of clinical, endoscopic, and radiographic response to ustekinumab in moderate-to-severe Crohn’s disease: real-world experience from a multicenter cohort study. Inflamm Bowel Dis. 2017;23(5):833–9.
Khorrami S, et al. Ustekinumab for the treatment of refractory Crohn’s disease: the spanish experience in a large multicentre open-label cohort. Inflamm Bowel Dis. 2016;22(7):1662–9.
Chaparro M, et al. Long-term durability and safety of Ustekinuman (UST) in patients with active Crohn's disease (CD) in real life: SUSTAIN study [abstract]. In: 28th United European Gastroenterology Week. 2020: Virtual. 407–408.
Chaparro M, et al. Effectiveness and safety of Ustekinumab (UST) in patients with active Crohn's disease (CD) in real life: SUSTAIN study [abstract]. In: 28th United European Gastroenterology Week. 2020: Virtual. 406–407.
Truyens M, et al. Efficacy of Ustekinumab intensification and re-induction in Crohn’s disease patients with insufficient or loss of response. Unit Eur Gastroenterol J. 2019;7(8 suppl): 645–645
Glassner K, et al. Low levels of ustekinumab despite dose escalation is a risk factor for surgery. Am Coll Gastroenterol. 2019;114:S405.
Ramaswamy PK, et al. MO1869 Efficacy of dose intensification of ustekinumab in Crohn's disease. Gastroenterology. 2020;S-956.
Sipponen T, et al. A nationwide real-world study on dynamic ustekinumab dosing and concomitant medication use among Crohn’s disease patients in Finland. Scand J Gastroenterol. 2021;56(6):661–70.
Article CAS PubMed Google Scholar
Biemans VBC, et al. Vedolizumab for inflammatory bowel disease: two-year results of the initiative on Crohn and Colitis (ICC) registry, a nationwide prospective observational cohort study. Clin Pharmacol Ther. 2020;107:1189–99.
Article CAS PubMed Google Scholar
Biemans V, et al. Two year experience with vedolizumab in inflammatory bowel disease patients: results of the ICC case series, a nationwide prospective observational cohort study. J Crohns Colitis. 2019;13:S363–4.
Attauabi M, et al. Short and long-term effectiveness and safety of vedolizumab in treatment-refractory patients with ulcerative colitis and Crohn's disease—a real-world two-center cohort study. Eur J Gastroenterol Hepatol. 2021;33(1S Suppl 1): e709-e718.
Attauabi M, et al. Treatment optimization with vedolizumab in treatment-refractory patients with ulcerative colitis and Crohn’s disease—a real-world two-center cohort study [abstract]. In: 29th United European Gastroenterology Week. 2021:550.
Shivashankar R, et al. Effect of vedolizumab dose escalation on recapturing response in patients with inflammatory bowel disease. Gastroenterol. 2017;152(5).
Mendoza Ladd AH, et al. Sa1086 Dose Escalation of Vedolizumab From Every 8 Weeks to Every 4 or 6 Weeks Enables Patients With Inflammatory Bowel Disease to Recapture Response. In: Gastroenterology. 2016:S235-S236.
Iborra M, et al. Vedolizumab, an option in patients with inflammatory bowel disease intolerant to thiopurines and refractory to biological agents. Gastroenterología y Hepatología (English Edition). 2018;41(9):535–43.
Iborra M, et al. Vedolizumab, an adequate option in medically refractory and thiopurine-intolerant inflammatory bowel disease patients. J Crohns Colitis. 2018;12:S472–3.
Dulai PS, et al. The real-world effectiveness and safety of vedolizumab for moderate-severe Crohn’s disease: results from the US VICTORY consortium. Am J Gastroenterol. 2016;111(8):1147–55.
Article CAS PubMed Google Scholar
Amiot A, et al. One-year effectiveness and safety of Vedolizumab therapy for inflammatory bowel disease: a prospective multicentre cohort study. Aliment Pharmacol Ther. 2017;46(3):310–21.
Article CAS PubMed Google Scholar
Amiot A, et al. Three-year effectiveness and safety of Vedolizumab therapy for inflammatory bowel disease: a prospective multi-centre cohort study. Aliment Pharmacol Ther. 2019;50(1):40–53.
Article CAS PubMed Google Scholar
Srinivasan A, et al. A virtual clinic increases anti-TNF dose intensification success via a treat-to-target approach compared with standard outpatient care in Crohn’s disease. Aliment Pharmacol Ther. 2020;51(12):1342–52.
Article CAS PubMed Google Scholar
Suzuki T, et al. Adalimumab dose escalation therapy is effective in refractory Crohn’s disease patients with loss of response to adalimumab, especially in cases without previous infliximab treatment. Case Rep Gastroenterol. 2019;13(1):37–49.
Article PubMed PubMed Central Google Scholar
Olivares D, et al. Differences in the need for Adalimumab dose optimization between Crohn’s disease and Ulcerative Colitis. Rev Esp Enferm Dig. 2019;111(11):846–51.
留言 (0)