Hodes, G. E. et al. Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress. Proc. Natl Acad. Sci. USA 111, 16136–16141 (2014).
Article CAS PubMed PubMed Central Google Scholar
McKim, D. B. et al. Microglial recruitment of IL-1β-producing monocytes to brain endothelium causes stress-induced anxiety. Mol. Psychiatry 23, 1421–1431 (2018).
Article CAS PubMed Google Scholar
Nie, X. et al. The innate immune receptors TLR2/4 mediate repeated social defeat stress-induced social avoidance through prefrontal microglial activation. Neuron 99, 464–479 (2018).
Article CAS PubMed Google Scholar
Pearson-Leary, J. et al. The gut microbiome regulates the increases in depressive-type behaviors and in inflammatory processes in the ventral hippocampus of stress vulnerable rats. Mol. Psychiatry 25, 1068–1079 (2020).
Haroon, E., Raison, C. L. & Miller, A. H. Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior. Neuropsychopharmacology 37, 137–162 (2012).
Article CAS PubMed Google Scholar
Sakamoto, S. et al. Alterations in circulating extracellular vesicles underlie social stress-induced behaviors in mice. FEBS Open Bio 11, 2678–2692 (2021).
Article CAS PubMed PubMed Central Google Scholar
Biltz, R. G., Sawicki, C. M., Sheridan, J. F. & Godbout, J. P. The neuroimmunology of social-stress-induced sensitization. Nat. Immunol. 23, 1527–1535 (2022).
Article CAS PubMed Google Scholar
Ribot, J. C., Lopes, N. & Silva-Santos, B. γδ T cells in tissue physiology and surveillance. Nat. Rev. Immunol. 21, 221–232 (2021).
Article CAS PubMed Google Scholar
Jin, C. et al. Commensal microbiota promote lung cancer development via γδ T cells. Cell 176, 998–1013 (2019).
Article CAS PubMed PubMed Central Google Scholar
Shichita, T. et al. Pivotal role of cerebral interleukin-17-producing γδT cells in the delayed phase of ischemic brain injury. Nat. Med. 15, 946–950 (2009).
Article CAS PubMed Google Scholar
Dupraz, L. et al. Gut microbiota-derived short-chain fatty acids regulate IL-17 production by mouse and human intestinal γδ T cells. Cell Rep. 36, 109332 (2021).
Article CAS PubMed Google Scholar
Filiano, A. J. et al. Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour. Nature 535, 425–429 (2016).
Article CAS PubMed PubMed Central Google Scholar
Alves de Lima, K. et al. Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons. Nat. Immunol. 21, 1421–1429 (2020).
Article CAS PubMed Google Scholar
Ribeiro, M. et al. Meningeal γδ T cell-derived IL-17 controls synaptic plasticity and short-term memory. Sci. Immunol. 4, eaay5199 (2019).
Article CAS PubMed PubMed Central Google Scholar
Benakis, C. et al. Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells. Nat. Med. 22, 516–523 (2016).
Article CAS PubMed PubMed Central Google Scholar
Choi, G. B. et al. The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring. Science 351, 933–939 (2016).
Article CAS PubMed PubMed Central Google Scholar
Medina-Rodriguez, E. M. et al. Identification of a signaling mechanism by which the microbiome regulates Th17 cell-mediated depressive-like behaviors in mice. Am. J. Psychiatry 177, 974–990 (2020).
Article PubMed PubMed Central Google Scholar
Brown, G. D. Dectin-1: a signalling non-TLR pattern-recognition receptor. Nat. Rev. Immunol. 6, 33–43 (2006).
Article CAS PubMed Google Scholar
Martin, B., Hirota, K., Cua, D. J., Stockinger, B. & Veldhoen, M. Interleukin-17-producing γδ T cells selectively expand in response to pathogen products and environmental signals. Immunity 31, 321–330 (2009).
Article CAS PubMed Google Scholar
Kamiya, T. et al. β-Glucans in food modify colonic microflora by inducing antimicrobial protein, calprotectin, in a Dectin-1-induced-IL-17F-dependent manner. Mucosal Immunol. 11, 763–773 (2018).
Article CAS PubMed Google Scholar
Tang, C. et al. Inhibition of Dectin-1 signaling ameliorates colitis by inducing Lactobacillus-mediated regulatory T cell expansion in the intestine. Cell Host Microbe 18, 183–197 (2015).
Article CAS PubMed Google Scholar
Zhu, X. et al. JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress. Neuropsychopharmacology 44, 683–694 (2019).
Article CAS PubMed Google Scholar
Burokas, A. et al. Targeting the microbiota–gut–brain axis: prebiotics have anxiolytic and antidepressant-like effects and reverse the impact of chronic stress in mice. Biol. Psychiatry 82, 472–487 (2017).
Article CAS PubMed Google Scholar
Gao, X. et al. Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response. Proc. Natl Acad. Sci. USA 115, E2960–E2969 (2018).
Article PubMed PubMed Central Google Scholar
Lee, Y. K., Menezes, J. S., Umesaki, Y. & Mazmanian, S. K. Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Proc. Natl Acad. Sci USA 108, 4615–4622 (2011).
Article CAS PubMed Google Scholar
Atarashi, K. et al. Induction of colonic regulatory T cells by indigenous Clostridium species. Science 331, 337–341 (2011).
Article CAS PubMed Google Scholar
Yohn, C. N. et al. Chronic non-discriminatory social defeat is an effective chronic stress paradigm for both male and female mice. Neuropsychopharmacology 44, 2220–2229 (2019).
Article CAS PubMed PubMed Central Google Scholar
Harris, A. Z. et al. A novel method for chronic social defeat stress in female mice. Neuropsychopharmacology 43, 1276–1283 (2018).
Nielsen, M. M., Witherden, D. A. & Havran, W. L. γδ T cells in homeostasis and host defence of epithelial barrier tissues. Nat. Rev. Immunol. 17, 733–745 (2017).
Article CAS PubMed PubMed Central Google Scholar
Vantourout, P. & Hayday, A. Six-of-the-best: unique contributions of γδ T cells to immunology. Nat. Rev. Immunol. 13, 88–100 (2013).
Article CAS PubMed PubMed Central Google Scholar
Taylor, P. R. et al. Dectin-1 is required for β-glucan recognition and control of fungal infection. Nat. Immunol. 8, 31–38 (2007).
Article CAS PubMed Google Scholar
Iliev, I. D. et al. Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis. Science 336, 1314–1317 (2012).
Article CAS PubMed PubMed Central Google Scholar
Goodridge, H. S. et al. Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’. Nature 472, 471–475 (2011).
Article CAS PubMed PubMed Central Google Scholar
Charlet, R., Bortolus, C., Sendid, B. & Jawhara, S. Bacteroides thetaiotaomicron and Lactobacillus johnsonii modulate intestinal inflammation and eliminate fungi via enzymatic hydrolysis of the fungal cell wall. Sci. Rep. 10, 11510 (2020).
Article CAS PubMed PubMed Central Google Scholar
Yuan, N. et al. An integrated pharmacology-based analysis for antidepressant mechanism of Chinese herbal formula Xiao-Yao-San. Front. Pharm. 11, 284 (2020).
Sutton, C. E. et al. Interleukin-1 and IL-23 induce innate IL-17 production from γδ T cells, amplifying Th17 responses and autoimmunity. Immunity 31, 331–341 (2009).
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