Interim position statement on doxycycline post-exposure prophylaxis (Doxy-PEP) for the prevention of bacterial sexually transmissible infections in Australia and Aotearoa New Zealand – the Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine (ASHM)

+ Author Affiliations - Author Affiliations

A The Australasian Society for HIV, Viral Hepatitis, and Sexual Health Medicine (ASHM), Sydney, NSW, Australia.

B The Kirby Institute, University of NSW, Sydney, NSW, Australia.

C Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Vic., Australia.

D NSW Health, Sydney, NSW, Australia.

E Melbourne Sexual Health Centre, Alfred Health, Melbourne, Vic., Australia.

F Clinical Research Department, London School of Hygiene and Tropical Medicine, London, UK.

G Centre for Population Health, NSW Health, Sydney, NSW, Australia.

H HNE Sexual Health, Hunter New England Health District, New Lambton, NSW, Australia.

I Northern Sydney Local Health District Sexual Health Service, NSW, Australia.

J Faculty of Health and Medicine, Northern Clinical School, University of Sydney, Sydney, NSW, Australia.

K Sydney Sexual Health Centre, South Eastern Sydney Local Health District, Sydney, NSW 2001, Australia.

L Townsville Hospital and Health Service, Queensland Health, 100 Angus Smith Drive, Douglas, Qld 4814, Australia.

M Sexual Health Services, Te Whatu Ora Bay of Plenty and Lakes, Tauranga and Rotorua, New Zealand (Aotearoa).

N Faculty of Medicine, School of Public Health, The University of Queensland, 288 Herston Road, Herston, Qld 4006, Australia.

O Department of Infectious Diseases, University of Paris Cité, St-Louis and Lariboisière Hospitals, APHP, Paris, France.

© 2023 The Author(s) (or their employer(s)). Published by CSIRO Publishing. This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND)

[1]  Hammoud MA, Maher L, Holt M, Degenhardt L, Jin F, Murphy D, et al. Physical distancing due to COVID-19 disrupts sexual behaviors among gay and bisexual men in Australia: implications for trends in HIV and other sexually transmissible infections. J Acquir Immune Defic Syndr 2020; 85 309–15.
Physical distancing due to COVID-19 disrupts sexual behaviors among gay and bisexual men in Australia: implications for trends in HIV and other sexually transmissible infections.Crossref | GoogleScholarGoogle Scholar | [2]  Chow EPF, Hocking JS, Ong JJ, Phillips TR, Fairley CK. Sexually transmitted infection diagnoses and access to a sexual health service before and after the national lockdown for COVID-19 in Melbourne, Australia. Open Forum Infect Dis 2021; 8 ofaa536
Sexually transmitted infection diagnoses and access to a sexual health service before and after the national lockdown for COVID-19 in Melbourne, Australia.Crossref | GoogleScholarGoogle Scholar | [3]  King J, McManus H, Kwon A, Gray R, McGregor S. HIV, viral hepatitis and sexually transmissible infections in Australia: Annual surveillance report 2022. Sydney: The Kirby Institute, UNSW Sydney; 2022. [4]  Brecher EM. Prevention of the sexually transmitted diseases. J Sex Res 1975; 11 318–28.
Prevention of the sexually transmitted diseases.Crossref | GoogleScholarGoogle Scholar | [5]  O’Keefe BG, Smith FB. Medicine at war: medical aspects of Australia’s involvement in Southeast Asia 1950–1972 with Agent Orange: the Australian aftermath.St. Leonards, NSW: Allen & Unwin in association with the Australian War Memorial; 1994. [6]  San Francisco Department of Public Health. Health Update - Doxycycline Post-Exposure Prophylaxis Reduces Incidence of Sexually Transmitted Infections. San Francisco: San Francisco Department of Public Health; 2022. Available at https://www.sfcdcp.org/wp-content/uploads/2022/10/Health-Update-Doxycycline-Post-Exposure-Prophylaxis-Reduces-Incidence-of-Sexually-Transmitted-Infections-SFDPH-FINAL-10.20.2022.pdf [cited 9 December 2022] [7]  Gandhi RT, Bedimo R, Hoy JF, Landovitz RJ, Smith DM, Eaton EF, et al. Antiretroviral drugs for treatment and prevention of HIV infection in adults: 2022 recommendations of the international antiviral society-USA Panel. JAMA 2023; 329 63–84.
Antiretroviral drugs for treatment and prevention of HIV infection in adults: 2022 recommendations of the international antiviral society-USA Panel.Crossref | GoogleScholarGoogle Scholar | [8]  Kohli M, Medland N, Fifer H, Saunders J. BASHH updated position statement on doxycycline as prophylaxis for sexually transmitted infections. Sex Transm Infect 2022; 98 235–36.
BASHH updated position statement on doxycycline as prophylaxis for sexually transmitted infections.Crossref | GoogleScholarGoogle Scholar | [9]  Chow EPF, Fairley CK. Use of doxycycline prophylaxis among gay and bisexual men in Melbourne. The Lancet HIV 2019; 6 e568–9.
Use of doxycycline prophylaxis among gay and bisexual men in Melbourne.Crossref | GoogleScholarGoogle Scholar | [10]  Luetkemeyer A, Dombrowski J, Cohen S, Donnell D, Grabow C, Brown C, et al., editors. Doxycycline post-exposure prophylaxis for STI prevention among MSM and transgender women on HIV PrEP or living with HIV: high efficacy to reduce incident STI’s in a randomized trial. The 24th International AIDS Conference, Montreal, Canada; 2022. [11]  Molina J-M, Bercot B, Assoumou L, Michele I-G, Rubenstein E, Pialoux G, et al., editors. ANRS 174 DOXYVAC: an open-label randomized trial to prevent STIs in MSM on PrEP. Conference on Retroviruses and Opportunistic Infections (CROI), 19–22 February 2023, Seattle, Washington; 2023. [12]  Bolan RK, Beymer MR, Weiss RE, Flynn RP, Leibowitz AA, Klausner JD. Doxycycline prophylaxis to reduce incident syphilis among HIV-infected men who have sex with men who continue to engage in high-risk sex: a randomized, controlled pilot study. Sex Transm Dis 2015; 42 98–103.
Doxycycline prophylaxis to reduce incident syphilis among HIV-infected men who have sex with men who continue to engage in high-risk sex: a randomized, controlled pilot study.Crossref | GoogleScholarGoogle Scholar | [13]  Molina JM, Charreau I, Chidiac C, Pialoux G, Cua E, Delaugerre C, et al. Post-exposure prophylaxis with doxycycline to prevent sexually transmitted infections in men who have sex with men: an open-label randomised substudy of the ANRS IPERGAY trial. Lancet Infect Dis 2018; 18 308–17.
Post-exposure prophylaxis with doxycycline to prevent sexually transmitted infections in men who have sex with men: an open-label randomised substudy of the ANRS IPERGAY trial.Crossref | GoogleScholarGoogle Scholar | [14]  Lahra MM, Hogan TR, Armstrong BH. Australian Gonococcal Surveillance Programme Annual Report, 2021. Commun Dis Intell 2022; 46
Australian Gonococcal Surveillance Programme Annual Report, 2021.Crossref | GoogleScholarGoogle Scholar | [15]  Straub C, Thirkell C, Dyet K. Antimicrobial resistance and molecular epidemiology of Neisseria gonorrhoeae in New Zealand, 2018–2019. Ministry of Health of New Zealand; 2021. Report No. FW21002 [updated June 2021]. Available at https://surv.esr.cri.nz/PDF_surveillance/Antimicrobial/Gono/NgonoSurvey2019_FINAL.pdf [16]  Luetkemeyer AF, Donnell D, Dombrowski JC, Cohen S, Grabow C, Brown C, et al., editors. Doxy-PEP and antimicrobial resistance in S. aureus, N. gonorrhoeae, and commensal Neisseria. Conference on Retroviruses and Opportunistic Infections (CROI), 19–22 February 2023, Seattle, Washington; 2023. [17]  Peyriere H, Makinson A, Marchandin H, Reynes J. Doxycycline in the management of sexually transmitted infections. J Antimicrob Chemother 2018; 73 553–63.
Doxycycline in the management of sexually transmitted infections.Crossref | GoogleScholarGoogle Scholar | [18]  Chen XS, Yin YP, Wei WH, Wang HC, Peng RR, Zheng HP, et al. High prevalence of azithromycin resistance to Treponema pallidum in geographically different areas in China. Clin Microbiol Infect 2013; 19 975–9.
High prevalence of azithromycin resistance to Treponema pallidum in geographically different areas in China.Crossref | GoogleScholarGoogle Scholar | [19]  Vodstrcil LA, Plummer EL, Doyle M, Murray GL, Bodiyabadu K, Jensen JS, et al. Combination therapy for Mycoplasma genitalium, and new insights into the utility of parC mutant detection to improve cure. Clin Infect Dis 2022; 75 813–23.
Combination therapy for Mycoplasma genitalium, and new insights into the utility of parC mutant detection to improve cure.Crossref | GoogleScholarGoogle Scholar | [20]  Bradley I, Varma R, Knight V, Iliakis D, McNally L, Jalocon D, et al. Prevalence of rectal Mycoplasma genitalium and macrolide resistance in men who have sex with men attending Sydney Sexual Health Centre. Sex Health 2020; 17 114–20.
Prevalence of rectal Mycoplasma genitalium and macrolide resistance in men who have sex with men attending Sydney Sexual Health Centre.Crossref | GoogleScholarGoogle Scholar | [21]  Read TRH, Murray GL, Danielewski JA, Fairley CK, Doyle M, Worthington K, et al. Symptoms, sites, and significance of Mycoplasma genitalium in men who have sex with men. Emerg Infect Dis 2019; 25 719–27.
Symptoms, sites, and significance of Mycoplasma genitalium in men who have sex with men.Crossref | GoogleScholarGoogle Scholar | [22]  Ong JJ, Bourne C, Dean JA, Ryder N, Cornelisse VJ, Murray S, et al. Australian sexually transmitted infection (STI) management guidelines for use in primary care 2022 update. Sex Health 2022; 20 1–8.
Australian sexually transmitted infection (STI) management guidelines for use in primary care 2022 update.Crossref | GoogleScholarGoogle Scholar | [23]  Sweeney EL, Bradshaw CS, Murray GL, Whiley DM. Individualised treatment of Mycoplasma genitalium infection-incorporation of fluoroquinolone resistance testing into clinical care. Lancet Infect Dis 2022; 22 e267–70.
Individualised treatment of Mycoplasma genitalium infection-incorporation of fluoroquinolone resistance testing into clinical care.Crossref | GoogleScholarGoogle Scholar | [24]  Antimicrobial Resistance Collaborators Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet 2022; 399 629–55.
Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis.Crossref | GoogleScholarGoogle Scholar | [25]  Truong R, Tang V, Grennan T, Tan DHS. A systematic review of the impacts of oral tetracycline class antibiotics on antimicrobial resistance in normal human flora. JAC Antimicrob Resist 2022; 4 dlac009
A systematic review of the impacts of oral tetracycline class antibiotics on antimicrobial resistance in normal human flora.Crossref | GoogleScholarGoogle Scholar | [26]  Australian Strategic and Technical Advisory Group on Antimicrobial Resistance (ASTAG). Importance Ratings and Summary of Antibacterial Uses in Human and Animal Health in Australia, Version 1.0. ASTAG; 2018. [27]  Grant JS, Stafylis C, Celum C, Grennan T, Haire B, Kaldor J, et al. Doxycycline prophylaxis for bacterial sexually transmitted infections. Clin Infect Dis 2020; 70 1247–53.
Doxycycline prophylaxis for bacterial sexually transmitted infections.Crossref | GoogleScholarGoogle Scholar | [28]  Graber EM. Treating acne with the tetracycline class of antibiotics: a review. Dermatol Rev 2021; 2 321–30.
Treating acne with the tetracycline class of antibiotics: a review.Crossref | GoogleScholarGoogle Scholar | [29]  Granados-Chinchilla F, Rodriguez C. Tetracyclines in food and feedingstuffs: from regulation to analytical methods, bacterial resistance, and environmental and health implications. J Anal Methods Chem 2017; 2017 1315497
Tetracyclines in food and feedingstuffs: from regulation to analytical methods, bacterial resistance, and environmental and health implications.Crossref | GoogleScholarGoogle Scholar | [30]  Australian Pesticides and Veterinary Medicines Authority. Quantity of antimicrobial products sold for veterinary use in Australia, July 2005 to June 2010. Australian Pesticides and Veterinary Medicines Authority; 2014. [31]  Kenyon C, Baetselier ID, Wouters K. Screening for STIs in PrEP cohorts results in high levels of antimicrobial consumption. Int J STD AIDS 2020; 31 1215–18.
Screening for STIs in PrEP cohorts results in high levels of antimicrobial consumption.Crossref | GoogleScholarGoogle Scholar | [32]  Moura IB, Grada A, Spittal W, Clark E, Ewin D, Altringham J, et al. Profiling the effects of systemic antibiotics for acne, including the narrow-spectrum antibiotic sarecycline, on the human gut microbiota. Front Microbiol 2022; 13 901911
Profiling the effects of systemic antibiotics for acne, including the narrow-spectrum antibiotic sarecycline, on the human gut microbiota.Crossref | GoogleScholarGoogle Scholar | [33]  Vijay A, Valdes AM. Role of the gut microbiome in chronic diseases: a narrative review. Eur J Clin Nutr 2022; 76 489–501.
Role of the gut microbiome in chronic diseases: a narrative review.Crossref | GoogleScholarGoogle Scholar | [34]  Angelakis E. Weight gain by gut microbiota manipulation in productive animals. Microb Pathog 2017; 106 162–70.
Weight gain by gut microbiota manipulation in productive animals.Crossref | GoogleScholarGoogle Scholar |

留言 (0)

沒有登入
gif