F. Bray, J. Ferlay, I. Soerjomataram, R.L. Siegel, L.A. Torre, A. Jemal, Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 68, 394–424 (2018)
J.H. Kim, Chemotherapy for colorectal cancer in the elderly. World J. Gastroenterol. 21, 5158–5166 (2015)
Article CAS PubMed PubMed Central Google Scholar
P. Balakumar, Y.H. Nyo, R. Renushia, D. Raaginey, A.N. Oh, R. Varatharajan, S.A. Dhanaraj, Classical and pleiotropic actions of dipyridamole: Not enough light to illuminate the dark tunnel? Pharmacol. Res. 87, 144–50 (2014)
M. Keller, K. Rohlf, A. Glotzbach, G. Leonhardt, S. Luke, K. Derksen, O. Demirci, D. Gocener, M. AlWahsh, J. Lambert, C. Lindskog, M. Schmidt, W. Brenner, M. Baumann, E. Zent, M.L. Zischinsky, B. Hellwig, K. Madjar, J. Rahnenfuhrer, N. Overbeck, J. Reinders, C. Cadenas, J.G. Hengstler, K. Edlund, R. Marchan, Inhibiting the glycerophosphodiesterase EDI3 in ER-HER2 + breast cancer cells resistant to HER2-targeted therapy reduces viability and tumour growth. J. Exp. Clin. Cancer Res. 42, 25 (2023)
Article CAS PubMed PubMed Central Google Scholar
J. Gao, C. Zhou, Y. Zhong, L. Shi, X. Luo, H. Su, M. Li, Y. Xu, N. Zhang, H. Zhou, Dipyridamole interacts with the N-terminal domain of HSP90 and antagonizes the function of the chaperone in multiple cancer cell lines. Biochem. Pharmacol. 207, 115376 (2023)
Article CAS PubMed Google Scholar
S.M. Ge, D.L. Zhan, S.H. Zhang, L.Q. Song, W.W. Han, Reverse screening approach to identify potential anti-cancer targets of dipyridamole. Am. J. Transl Res. 8, 5187–5198 (2016)
CAS PubMed PubMed Central Google Scholar
M.P. Thome, C. Borde, A.K. Larsen, J.A.P. Henriques, G. Lenz, A.E. Escargueil, V. Marechal, Dipyridamole as a new drug to prevent Epstein-Barr virus reactivation. Antiviral Res. 172, 104615 (2019)
Article CAS PubMed Google Scholar
D. Spano, J.C. Marshall, N. Marino, D. De Martino, A. Romano, M.N. Scoppettuolo, A.M. Bello, V. Di Dato, L. Navas, G. De Vita, C. Medaglia, P.S. Steeg, M. Zollo, Dipyridamole prevents triple-negative breast-cancer progression. Clin. Exp. Metastasis 30, 47–68 (2013)
Article CAS PubMed Google Scholar
M.P. Thome, L.C. Pereira, G.R. Onzi, F. Rohden, M. Ilha, F.T. Guma, M.R. Wink, G. Lenz, Dipyridamole impairs autophagic flux and exerts antiproliferative activity on prostate cancer cells. Exp. Cell. Res. 382, 111456 (2019)
Article CAS PubMed Google Scholar
S. Zhou, H. Xu, Q. Tang, H. Xia, F. Bi, Dipyridamole enhances the cytotoxicities of trametinib against Colon cancer cells through combined targeting of HMGCS1 and MEK Pathway. Mol. Cancer Ther. 19, 135–146 (2020)
Article CAS PubMed Google Scholar
S. Choudhary, S. Sood, H.C. Wang, Dipyridamole intervention of breast cell carcinogenesis. Mol. Carcinog. 53, 243–252 (2014)
Article CAS PubMed Google Scholar
G.N. Tzanakakis, K.C. Agarwal, M.P. Vezeridis, Prevention of human pancreatic cancer cell-induced hepatic metastasis in nude mice by dipyridamole and its analog RA-233. Cancer 71, 2466–2471 (1993)
Article CAS PubMed Google Scholar
R.R. Mishra, N. Belder, S.A. Ansari, M. Kayhan, H. Bal, U. Raza, P.G. Ersan, U.M. Tokat, E. Eyupoglu, O. Saatci, P. Jandaghi, S. Wiemann, A. Uner, C. Cekic, Y. Riazalhosseini, O. Sahin, Reactivation of cAMP pathway by PDE4D Inhibition Represents a Novel Druggable Axis for overcoming tamoxifen resistance in ER-positive breast Cancer. Clin. Cancer Res. 24, 1987–2001 (2018)
Article CAS PubMed Google Scholar
J. Longo, P.J. Mullen, R. Yu, J.E. van Leeuwen, M. Masoomian, D.T.S. Woon, Y. Wang, E.X. Chen, R.J. Hamilton, J.M. Sweet, T.H. van der Kwast, N.E. Fleshner, L.Z. Penn, An actionable sterol-regulated feedback loop modulates statin sensitivity in prostate cancer. Mol. Metab. 25, 119–130 (2019)
Article CAS PubMed PubMed Central Google Scholar
A. Mehta, B.M. Patel, Therapeutic opportunities in colon cancer: focus on phosphodiesterase inhibitors. Life Sci. 230, 150–161 (2019)
Article CAS PubMed Google Scholar
W. Huang, J. Sundquist, K. Sundquist, J. Ji, Phosphodiesterase-5 inhibitors use and risk for mortality and metastases among male patients with colorectal cancer. Nat. Commun. 11, 3191 (2020)
Article CAS PubMed PubMed Central Google Scholar
W. Huang, J. Sundquist, K. Sundquist, J. Ji, Use of Phosphodiesterase 5 Inhibitors Is Associated With Lower Risk of Colorectal Cancer in Men With Benign Colorectal Neoplasms. Gastroenterology 157, 672–681 e4 (2019)
K. Krishnan, Z.K. Law, J.S. Minhas, P.M. Bath, T.G. Robinson, N. Sprigg, A. Mavilakandy, T.J. England, D. Eveson, A. Mistri, J. Dawson, J.P. Appleton, Antiplatelet treatment for acute secondary prevention of non-cardioembolic minor stroke / transient ischaemic attack: an update for the acute physician. Clin. Med. (Lond) 22, 449–454 (2022)
X. Hou, K. Cen, Y. Cui, Y. Zhang, X. Feng, Antiplatelet therapy for secondary prevention of lacunar stroke: a systematic review and network meta-analysis. Eur. J. Clin. Pharmacol. 79, 63–70 (2023)
Article CAS PubMed Google Scholar
J. Hybiak, I. Broniarek, G. Kiryczynski, L.D. Los, J. Rosik, F. Machaj, H. Slawinski, K. Jankowska, E. Urasinska, Aspirin and its pleiotropic application. Eur. J. Pharmacol. 866, 172762 (2020)
Article CAS PubMed Google Scholar
A. Greco, S. Finocchiaro, D.J. Angiolillo, D. Capodanno, Advances in the Available Pharmacotherapy for the Management of Acute Coronary Syndromes in Patients Presenting Without Persistent ST-segment Elevation (Expert Opin Pharmacother, 2023)
H. Hua, H. Zhang, Q. Kong, J. Wang, Y. Jiang, Complex roles of the old drug aspirin in cancer chemoprevention and therapy. Med. Res. Rev. 39, 114–145 (2019)
Article CAS PubMed Google Scholar
A. Grancher, P. Michel, F. Di Fiore, D. Sefrioui, Colorectal cancer chemoprevention: is aspirin still in the game? Cancer Biol. Ther. 23, 446–461 (2022)
Article CAS PubMed PubMed Central Google Scholar
J. Ji, J. Sundquist, K. Sundquist, Use of terbinafine and risk of death in patients with prostate cancer: a population-based cohort study. Int. J. Cancer 144, 1888–1895 (2019)
Article CAS PubMed Google Scholar
T.G. Simon, A.S. Duberg, S. Aleman, R.T. Chung, A.T. Chan, J.F. Ludvigsson, Association of aspirin with Hepatocellular Carcinoma and Liver-Related mortality. N Engl. J. Med. 382, 1018–1028 (2020)
Article CAS PubMed PubMed Central Google Scholar
M.E. Charlson, P. Pompei, K.L. Ales, C.R. MacKenzie, A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J. Chronic Dis. 40, 373–383 (1987)
Article CAS PubMed Google Scholar
X.L. Zhang, L.P. Hu, Q. Yang, W.T. Qin, X. Wang, C.J. Xu, G.A. Tian, X.M. Yang, L.L. Yao, L. Zhu, H.Z. Nie, Q. Li, Q. Xu, Z.G. Zhang, Y.L. Zhang, J. Li, Y.H. Wang, S.H. Jiang, CTHRC1 promotes liver metastasis by reshaping infiltrated macrophages through physical interactions with TGF-beta receptors in colorectal cancer. Oncogene 40, 3959–3973 (2021)
Article CAS PubMed Google Scholar
T. Shimura, S. Toden, N.L. Komarova, C. Boland, D. Wodarz, A. Goel, A comprehensive in vivo and mathematic modeling-based kinetic characterization for aspirin-induced chemoprevention in colorectal cancer. Carcinogenesis 41, 751–760 (2020)
Article CAS PubMed PubMed Central Google Scholar
R. Zhao, O.O. Coker, J. Wu, Y. Zhou, L. Zhao, G. Nakatsu, X. Bian, H. Wei, A.W.H. Chan, J.J.Y. Sung, F.K.L. Chan, E. El-Omar, J. Yu, Aspirin Reduces Colorectal Tumor Development in Mice and Gut Microbes Reduce its Bioavailability and Chemopreventive Effects. Gastroenterology 159, 969–983 e4 (2020)
T.C. Chou, P. Talalay, Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv. Enzyme Regul. 22, 27–55 (1984)
Article CAS PubMed Google Scholar
W. Huang da, B.T. Sherman, R.A. Lempicki, Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 37, 1–13 (2009)
W. Huang da, B.T. Sherman, R.A. Lempicki, Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc. 4, 44–57 (2009)
A. Subramanian, P. Tamayo, V.K. Mootha, S. Mukherjee, B.L. Ebert, M.A. Gillette, A. Paulovich, S.L. Pomeroy, T.R. Golub, E.S. Lander, J.P. Mesirov, Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. U S A 102, 15545–15550 (2005)
Article CAS PubMed PubMed Central Google Scholar
V.K. Mootha, C.M. Lindgren, K.F. Eriksson, A. Subramanian, S. Sihag, J. Lehar, P. Puigserver, E. Carlsson, M. Ridderstrale, E. Laurila, N. Houstis, M.J. Daly, N. Patterson, J.P. Mesirov, T.R. Golub, P. Tamayo, B. Spiegelman, E.S. Lander, J.N. Hirschhorn, D. Altshuler, L.C. Groop, PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat. Genet. 34, 267–273 (2003)
Article CAS PubMed Google Scholar
Y.X. Feng, E.S. Sokol, C.A. Del Vecchio, S. Sanduja, J.H. Claessen, T.A. Proia, D.X. Jin, F. Reinhardt, H.L. Ploegh, Q. Wang, P.B. Gupta, Epithelial-to-mesenchymal transition activates PERK-eIF2alpha and sensitizes cells to endoplasmic reticulum stress. Cancer Discov 4, 702–715 (2014)
Article CAS PubMed Google Scholar
S.T. Nawrocki, J.S. Carew, K. Dunner Jr., L.H. Boise, P.J. Chiao, P. Huang, J.L. Abbruzzese, D.J. McConkey, Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells. Cancer Res. 65, 11510–11519 (2005)
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