What is the role of brown adipose tissue in metabolic health: lessons learned and future perspectives in the long COVID?

Aquila H, Link TA, Klingenberg M (1985) The uncoupling protein from brown fat mitochondria is related to the mitochondrial ADP/ATP carrier. Analysis of sequence homologies and of folding of the protein in the membrane. EMBO J 4(9):2369–2376

Article  CAS  PubMed  PubMed Central  Google Scholar 

Basolo A, Poma AM, Bonuccelli D, Proietti A, Macerola E, Ugolini C, Torregrossa L, Giannini R, Vignali P, Basolo F, Santini F, Toniolo A (2022) Adipose tissue in COVID-19: detection of SARS-CoV-2 in adipocytes and activation of the interferon-alpha response. J Endocrinol Investig 45(5):1021–1029

Article  CAS  Google Scholar 

Bates R, Huang W, Cao L (2020) Adipose tissue: an emerging target for adeno-associated viral vectors. Mol Ther Methods Clin Dev. 19:236–249. https://doi.org/10.1016/j.omtm.2020.09.009

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bezpalko L, Gavrilyuk O, Zayachkivska O (2015) Inflammatory response in visceral fat tissue and liver is prenatally programmed: experimental research. J Physiol Pharmacol 66(1):57–64

CAS  PubMed  Google Scholar 

Callard F, Perego E (2021) How and why patients made Long Covid. Soc Sci Med 268:113426

Article  PubMed  PubMed Central  Google Scholar 

Cannon B, Nedergaard J (2004) Brown adipose tissue: function and physiological significance. Physiol Rev 84(1):277–359. https://doi.org/10.1152/physrev.00015.2003

Article  CAS  PubMed  Google Scholar 

de Lucena TMC, da Silva Santos AF, de Lima BR, de Albuquerque Borborema ME, de Azevêdo Silva J (2020) Mechanism of inflammatory response in associated comorbidities in COVID-19. Diabetes Metab Syndr 14(4):597–600

Article  PubMed  PubMed Central  Google Scholar 

Favre G, Legueult K, Pradier C, Raffaelli C, Ichai C, Iannelli A, Redheuil A, Lucidarme O, Esnault V (2021) Visceral fat is associated to the severity of COVID-19. Metabolism 115:154440

Article  CAS  PubMed  Google Scholar 

Finucane FM, Davenport C (2020) Coronavirus and obesity: could insulin resistance mediate the severity of Covid-19 infection? Front Public Health 8:184

Article  PubMed  PubMed Central  Google Scholar 

Frigolet ME, Gutiérrez-Aguilar R (2020) The colors of adipose tissue. Gac Med Mex 156(2):142–149. https://doi.org/10.24875/GMM.M20000356

Article  PubMed  Google Scholar 

Giordano A, Smorlesi A, Frontini A, Barbatelli G, Cinti S (2014) White, brown and pink adipocytes: the extraordinary plasticity of the adipose organ. Eur J Endocrinol 170(5):R159–R171. https://doi.org/10.1530/EJE-13-0945

Article  CAS  PubMed  Google Scholar 

Goossens GH (2017) The metabolic phenotype in obesity: fat mass, body fat distribution, and adipose tissue function. Obes Facts 10(3):207–215

Article  CAS  PubMed  PubMed Central  Google Scholar 

Harms M, Seale P (2013) Brown and beige fat: development, function and therapeutic potential. Nat Med 19(10):1252–1263. https://doi.org/10.1038/nm.3361. (Epub 2013 Sep 29)

Article  CAS  PubMed  Google Scholar 

Heaton GM, Wagenvoord RJ, Kemp A Jr, Nicholls DG (1978) Brown-adipose-tissue mitochondria: photoaffinity labelling of the regulatory site of energy dissipation. Eur J Biochem 82(2):515–521

Article  CAS  PubMed  Google Scholar 

Jeremic N, Chaturvedi P, Tyagi SC (2017) Browning of white fat: novel insight into factors, mechanisms, and therapeutics. J Cell Physiol 232(1):61–68

Article  CAS  PubMed  Google Scholar 

Jing X, Wu J, Dong C, Gao J, Seki T, Kim C, Urgard E, Hosaka K, Yang Y, Long S, Huang P, Zheng J, Szekely L, Zhang Y, Tao W, Coquet J, Ge M, Chen Y, Adner M, Cao Y (2022) COVID-19 instigates adipose browning and atrophy through VEGF in small mammals. Nat Metab 4:1674

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karkhut SM, Muzyka I, Savytska M, Dzhyoieva K, Pohoretska Y, Ivanchenko N, Zayachkivska O, Schloss JV, Szabo S (2021) Physiological predictors of long-term effects of COVID-19 in patients with SARS-CoV-2: focus on lymphocyte proliferation-improving micronutrients. Proc Shevchenko Sci Soc Med Sci. https://doi.org/10.25040/ntsh2021.02.06

Article  Google Scholar 

Krams IA, Luoto S, Rantala MJ, Jõers P, Krama T (2020) Covid-19: fat, obesity, inflammation, ethnicity, and sex differences. Pathogens 9(11):887

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kruglikov IL, Scherer PE (2020) The role of adipocytes and adipocyte-like cells in the severity of COVID-19 infections. Obesity 28(7):1187–1190. https://doi.org/10.1002/oby.22856

Article  CAS  PubMed  Google Scholar 

Loosen SH, Jensen BEO, Tanislav C, Luedde T, Roderburg C, Kostev K (2022) Obesity and lipid metabolism disorders determine the risk for development of long COVID syndrome: a cross-sectional study from 50,402 COVID-19 patients. Infection 50:1165–1170. https://doi.org/10.1007/s15010-022-01784-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marlatt KL, Ravussin E (2017) Brown adipose tissue: an update on recent findings. Curr Obes Rep 6(4):389–396. https://doi.org/10.1007/s13679-017-0283-6

Article  PubMed  PubMed Central  Google Scholar 

Morigny P, Houssier M, Mouisel E, Langin D (2016) Adipocyte lipolysis and insulin resistance. Biochimie 125:259–266

Article  CAS  PubMed  Google Scholar 

Rada P, González-Rodríguez Á, García-Monzón C, Valverde ÁM (2020) Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver? Cell Death Dis 11(9):1–15

Article  Google Scholar 

Reese JT, Blau H, Casiraghi E, Bergquist T, Loomba JJ, Callahan TJ, Laraway B, Antonescu C, Coleman B, Gargano M, Wilkins KJ, Cappelletti L, Fontana T, Ammar N, Antony B, Murali TM, Caufield JH, Karlebach G, McMurry JA, Williams A, Moffitt R, Banerjee J, Solomonides AE, Davis H, Kostka K, Valentini G, Sahner D, Chute CG, Madlock-Brown C, Haendel MA, Robinson PN, Divers J, N3C Consortium, RECOVER Consortium (2023) Generalisable long COVID subtypes: findings from the NIH N3C and RECOVER programmes. EBioMedicine 87:104413

Article  PubMed  Google Scholar 

Revenko O, Pavlovskiy Y, Savytska M, Yashchenko A, Kovalyshyn V, Chelpanova I, Varyvoda O, Zayachkivska O (2021) Hydrogen sulfide prevents mesenteric adipose tissue damage, endothelial dysfunction, and redox imbalance from high fructose diet-induced injury in aged rats. Front Pharmacol. https://doi.org/10.3389/fphar.2021.693100

Article  PubMed  PubMed Central  Google Scholar 

Revenko O, Zaichko N, Wallace J, Zayachkivska O (2018) Hydrogen sulfide system attenuates injury by hyperglycemia and stress: role of mesenteric adipocytes in aged animals. Proc Shevchenko Sci Soc Med Sci 54(2):115–124

Google Scholar 

Ricquier D, Bouillaud F (2000) Mitochondrial uncoupling proteins: from mitochondria to the regulation of energy balance. J Physiol 529(1):3–10

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ruderman NB, Schneider SH, Berchtold P (1981) The “metabolically-obese”, normal-weight individual. Am J Clin Nutr 34(8):1617–1621

Article  CAS  PubMed  Google Scholar 

Sattar N, McInnes IB, McMurray JJ (2020) Obesity is a risk factor for severe COVID-19 infection: multiple potential mechanisms. Circulation 142(1):4–6

Article  CAS  PubMed  Google Scholar 

Selye H, Timiras PS (1949) Participation of ‘brown fat’tissue in the alarm reaction. Nature 164(4174):745–746

Article  CAS  PubMed  Google Scholar 

Shimizu I, Walsh K (2015) The whitening of brown fat and its implications for weight management in obesity. Curr Obes Rep 4(2):224–229. https://doi.org/10.1007/s13679-015-0157-8

Article  PubMed  Google Scholar 

Stefan N (2023) SARS-CoV-2 fires up inflammation in adipose tissue. Nat Rev Endocrinol 19:8–9. https://doi.org/10.1038/s41574-022-00778-0

Article  CAS  PubMed  Google Scholar 

Tchkonia T, Morbeck DE, Von Zglinicki T, Van Deursen J, Lustgarten J, Scrable H, Jensen MD, Kirkland JL (2010) Fat tissue, aging, and cellular senescence. Aging Cell 9(5):667–684. https://doi.org/10.1111/j.1474-9726.2010.00608.x

Article  CAS  PubMed  Google Scholar 

World Health Organization. First-ever global coverage targets for diabetes adopted at the 75th World Health Assembly. (2022). https://www.who.int/news-room/feature-stories/detail/first-ever-global-coverage-targets-for-diabetes-adopted-at-the-75-th-world-health-assembly#:~:text=First-ever%20global%20coverage%20targets%20for%20diabetes%20adopted%20at,diabetes%20responses%20within%20national%20noncommunicable%20disease%20%28NCD%29%20programmes.

Zdrojewicz Z, Popowicz E, Szyca M, Michalik T, Śmieszniak B (2017) TOFI phenotype–its effect on the occurrence of diabetes. Pediatric Endocrinol Diabetes Metab 23(2):96

Article  Google Scholar 

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