Indirect epigenetic testing identifies a diagnostic signature of cardiomyocyte DNA methylation in heart failure

Alpert MA, Lavie CJ, Agrawal H, Aggarwal KB, Kumar SA (2014) Obesity and heart failure: epidemiology, pathophysiology, clinical manifestations, and management. Transl Res 164:345–356. https://doi.org/10.1016/j.trsl.2014.04.010

Article  CAS  PubMed  Google Scholar 

Bhuiyan MS, Pattison JS, Osinska H, James J, Gulick J, McLendon PM, Hill JA, Sadoshima J, Robbins J (2013) Enhanced autophagy ameliorates cardiac proteinopathy. J Clin Invest 123:5284–5297. https://doi.org/10.1172/JCI70877

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bird AP (1986) CpG-rich islands and the function of DNA methylation. Nature 321:209–213. https://doi.org/10.1038/321209a0

Article  CAS  PubMed  Google Scholar 

Burke MA, Cook SA, Seidman JG, Seidman CE (2016) Clinical and mechanistic insights into the genetics of cardiomyopathy. J Am Coll Cardiol 68:2871–2886. https://doi.org/10.1016/j.jacc.2016.08.079

Article  PubMed  PubMed Central  Google Scholar 

Chen H, Orozco LD, Wang J, Rau CD, Rubbi L, Ren S, Wang Y, Pellegrini M, Lusis AJ, Vondriska TM (2016) DNA methylation indicates susceptibility to isoproterenol-induced cardiac pathology and is associated with chromatin states. Circ Res 118:786–797. https://doi.org/10.1161/CIRCRESAHA.115.305298

Article  CAS  PubMed  PubMed Central  Google Scholar 

Collier JJ, Suomi F, Olahova M, McWilliams TG, Taylor RW (2021) Emerging roles of ATG7 in human health and disease. EMBO Mol Med 13:e14824. https://doi.org/10.15252/emmm.202114824

Article  CAS  PubMed  PubMed Central  Google Scholar 

Decock A, Ongenaert M, Cannoodt R, Verniers K, De Wilde B, Laureys G, Van Roy N, Berbegall AP, Bienertova-Vasku J, Bown N, Clement N, Combaret V, Haber M, Hoyoux C, Murray J, Noguera R, Pierron G, Schleiermacher G, Schulte JH, Stallings RL, Tweddle DA, De Preter K, Speleman F, Vandesompele J (2016) Methyl-CpG-binding domain sequencing reveals a prognostic methylation signature in neuroblastoma. Oncotarget 7:1960–1972. https://doi.org/10.18632/oncotarget.6477

Article  PubMed  Google Scholar 

Diakos NA, Taleb I, Kyriakopoulos CP, Shah KS, Javan H, Richins TJ, Yin MY, Yen CG, Dranow E, Bonios MJ, Alharethi R, Koliopoulou AG, Taleb M, Fang JC, Selzman CH, Stellos K, Drakos SG (2021) Circulating and myocardial cytokines predict cardiac structural and functional improvement in patients with heart failure undergoing mechanical circulatory support. J Am Heart Assoc 10:e020238. https://doi.org/10.1161/JAHA.120.020238

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fornaro L, Vivaldi C, Caparello C, Musettini G, Baldini E, Masi G, Falcone A (2016) Pharmacoepigenetics in gastrointestinal tumors: MGMT methylation and beyond. Front Biosci (Elite Ed) 8:170–180

Article  PubMed  Google Scholar 

Galluzzo A, Gallo S, Pardini B, Birolo G, Fariselli P, Boretto P, Vitacolonna A, Peraldo-Neia C, Spilinga M, Volpe A, Celentani D, Pidello S, Bonzano A, Matullo G, Giustetto C, Bergerone S, Crepaldi T (2021) Identification of novel circulating microRNAs in advanced heart failure by next-generation sequencing. ESC Heart Fail 8:2907–2919. https://doi.org/10.1002/ehf2.13371

Article  PubMed  PubMed Central  Google Scholar 

Gi WT, Haas J, Sedaghat-Hamedani F, Kayvanpour E, Tappu R, Lehmann DH, Shirvani Samani O, Wisdom M, Keller A, Katus HA, Meder B (2020) Epigenetic regulation of alternative mRNA splicing in dilated cardiomyopathy. J Clin Med. https://doi.org/10.3390/jcm9051499

Article  PubMed  PubMed Central  Google Scholar 

Gillette TG, Hill JA (2015) Readers, writers, and erasers: chromatin as the whiteboard of heart disease. Circ Res 116:1245–1253. https://doi.org/10.1161/CIRCRESAHA.116.303630

Article  CAS  PubMed  PubMed Central  Google Scholar 

Haas J, Frese KS, Park YJ, Keller A, Vogel B, Lindroth AM, Weichenhan D, Franke J, Fischer S, Bauer A, Marquart S, Sedaghat-Hamedani F, Kayvanpour E, Kohler D, Wolf NM, Hassel S, Nietsch R, Wieland T, Ehlermann P, Schultz JH, Dosch A, Mereles D, Hardt S, Backs J, Hoheisel JD, Plass C, Katus HA, Meder B (2013) Alterations in cardiac DNA methylation in human dilated cardiomyopathy. EMBO Mol Med 5:413–429. https://doi.org/10.1002/emmm.201201553

Article  CAS  PubMed  PubMed Central  Google Scholar 

Haider S, Cordeddu L, Robinson E, Movassagh M, Siggens L, Vujic A, Choy MK, Goddard M, Lio P, Foo R (2012) The landscape of DNA repeat elements in human heart failure. Genome Biol 13:R90. https://doi.org/10.1186/gb-2012-13-10-r90

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ho TT, Warr MR, Adelman ER, Lansinger OM, Flach J, Verovskaya EV, Figueroa ME, Passegue E (2017) Autophagy maintains the metabolism and function of young and old stem cells. Nature 543:205–210. https://doi.org/10.1038/nature21388

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jadli AS, Parasor A, Gomes KP, Shandilya R, Patel VB (2021) Exosomes in cardiovascular diseases: pathological potential of nano-messenger. Front Cardiovasc Med 8:767488. https://doi.org/10.3389/fcvm.2021.767488

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jjingo D, Conley AB, Yi SV, Lunyak VV, Jordan IK (2012) On the presence and role of human gene-body DNA methylation. Oncotarget 3:462–474. https://doi.org/10.18632/oncotarget.497

Article  PubMed  PubMed Central  Google Scholar 

Kenny HC, Abel ED (2019) Heart failure in type 2 diabetes mellitus. Circ Res 124:121–141. https://doi.org/10.1161/CIRCRESAHA.118.311371

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kronlage M, Dewenter M, Grosso J, Fleming T, Oehl U, Lehmann LH, Falcao-Pires I, Leite-Moreira AF, Volk N, Grone HJ, Muller OJ, Sickmann A, Katus HA, Backs J (2019) O-GlcNAcylation of histone deacetylase 4 protects the diabetic heart from failure. Circulation 140:580–594. https://doi.org/10.1161/CIRCULATIONAHA.117.031942

Article  CAS  PubMed  Google Scholar 

Lehmann LH, Worst BC, Stanmore DA, Backs J (2014) Histone deacetylase signaling in cardioprotection. Cell Mol Life Sci 71:1673–1690. https://doi.org/10.1007/s00018-013-1516-9

Article  CAS  PubMed  Google Scholar 

Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, Marth G, Abecasis G, Durbin R (2009) The sequence alignment/map format and SAMtools. Bioinformatics 25:2078–2079

Article  PubMed  PubMed Central  Google Scholar 

Love MI, Huber W, Anders S (2014) Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol 15:550

Article  PubMed  PubMed Central  Google Scholar 

Maksimovic J, Gordon L, Oshlack A (2012) SWAN: Subset-quantile within array normalization for illumina infinium HumanMethylation450 BeadChips. Genome Biol 13:R44. https://doi.org/10.1186/gb-2012-13-6-r44

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marzese DM, Witz IP, Kelly DF, Hoon DS (2015) Epigenomic landscape of melanoma progression to brain metastasis: unexplored therapeutic alternatives. Epigenomics 7:1303–1311. https://doi.org/10.2217/epi.15.77

Article  CAS  PubMed  Google Scholar 

Mazzarotto F, Tayal U, Buchan RJ, Midwinter W, Wilk A, Whiffin N, Govind R, Mazaika E, de Marvao A, Dawes TJW, Felkin LE, Ahmad M, Theotokis PI, Edwards E, Ing AY, Thomson KL, Chan LLH, Sim D, Baksi AJ, Pantazis A, Roberts AM, Watkins H, Funke B, O’Regan DP, Olivotto I, Barton PJR, Prasad SK, Cook SA, Ware JS, Walsh R (2020) Reevaluating the genetic contribution of monogenic dilated cardiomyopathy. Circulation 141:387–398. https://doi.org/10.1161/CIRCULATIONAHA.119.037661

Article  CAS  PubMed  PubMed Central  Google Scholar 

McKinsey TA (2012) Therapeutic potential for HDAC inhibitors in the heart. Annu Rev Pharmacol Toxicol 52:303–319. https://doi.org/10.1146/annurev-pharmtox-010611-134712

Article  CAS  PubMed  Google Scholar 

McKinsey TA, Vondriska TM, Wang Y (2018) Epigenomic regulation of heart failure: integrating histone marks, long noncoding RNAs, and chromatin architecture. F1000Res. https://doi.org/10.12688/f1000research.15797.1

Article  PubMed  PubMed Central  Google Scholar 

Meder B, Haas J, Sedaghat-Hamedani F, Kayvanpour E, Frese K, Lai A, Nietsch R, Scheiner C, Mester S, Bordalo DM, Amr A, Dietrich C, Pils D, Siede D, Hund H, Bauer A, Holzer DB, Ruhparwar A, Mueller-Hennessen M, Weichenhan D, Plass C, Weis T, Backs J, Wuerstle M, Keller A, Katus HA, Posch AE (2017) Epigenome-wide association study identifies cardiac gene patterning and a novel class of biomarkers for heart failure. Circulation 136:1528–1544. https://doi.org/10.1161/CIRCULATIONAHA.117.027355

Article  CAS  PubMed  Google Scholar 

Meijer van Putten RM, Mengarelli I, Guan K, Zegers JG, van Ginneken AC, Verkerk AO, Wilders R (2015) Ion channelopathies in human induced pluripotent stem cell derived cardiomyocytes: a dynamic clamp study with virtual IK1. Front Physiol 6:7. https://doi.org/10.3389/fphys.2015.00007

Article  PubMed  PubMed Central  Google Scholar 

Mentkowski KI, Lang JK (2019) Exosomes engineered to express a cardiomyocyte binding peptide demonstrate improved cardiac retention in vivo. Sci Rep 9:10041. https://doi.org/10.1038/s41598-019-46407-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Movassagh M, Choy MK, Knowles DA, Cordeddu L, Haider S, Down T, Siggens L, Vujic A, Simeoni I, Penkett C, Goddard M, Lio P, Bennett MR, Foo RS (2011) Distinct epigenomic features in end-stage failing human hearts. Circulation 124:2411–2422. https://doi.org/10.1161/CIRCULATIONAHA.111.040071

Article  PubMed  PubMed Central 

留言 (0)

沒有登入
gif