Anticancer Activity of Diosgenin and Its Molecular Mechanism

Arya P, Kumar P. Comparison of ultrasound and microwave assisted extraction of diosgenin from Trigonella foenum graceum seed. Ultrason Sonochem 2021;74:105572.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen W, Zhang Y, Gu X, et al. Qi Ling decoction reduces gastric cancer cell metastasis by inhibiting MMP-9 through the PI3K/Akt signaling pathway. Am J Transl Res 2021;13:4591–4602.

CAS  PubMed  PubMed Central  Google Scholar 

Al-Habori M, Raman A, Lawrence MJ, et al. In vitro effect of fenugreek extracts on intestinal sodium-dependent glucose uptake and hepatic glycogen phosphorylase A. Int J Exp Diabetes Res 2001;2:91–99.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu FC, Jiang JG. Effects of diosgenin and its derivatives on atherosclerosis. Food Funct 2019;10:7022–7036.

Article  CAS  PubMed  Google Scholar 

Wang HW, Liu HJ, Cao H, et al. Diosgenin protects rats from myocardial inflammatory injury induced by ischemia-reperfusion. Med Sci Monit 2018;24:246–253.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang R, Sun Y, Jin X, et al. Diosgenin inhibits excessive proliferation and inflammatory response of synovial fibroblasts in rheumatoid arthritis by targeting PDE3B. Inflammation 2021;44:946–955.

Article  CAS  PubMed  Google Scholar 

Zhao H, Zhang X, Zhang B, et al. Gastroprotective effects of diosgenin against HCl/ethanol-induced gastric mucosal injury through suppression of NF-κβ and myeloperoxidase activities. Open Life Sci 2021;16:719–727.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang CH, Pan CL, Tsai GJ, et al. Anti-allergic diarrhea effect of diosgenin occurs via improving gut dysbiosis in a murine model of food allergy. Molecules 2021;26:2471.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mischitelli M, Jemaa M, Almasry M, et al. Ca2+ entry, oxidative stress, ceramide and suicidal erythrocyte death following diosgenin treatment. Cell Physiol Biochem 2016;39:1626–1637.

Article  CAS  PubMed  Google Scholar 

Zhong Y, Jin C, Han J, et al. Diosgenin protects against kidney injury and mitochondrial apoptosis induced by 3-MCPD through the regulation of ER stress, Ca2+ homeostasis, and Bcl2 expression. Mol Nutr Food Res 2021;65:e2001202.

Article  PubMed  Google Scholar 

Zeinali H, Baluchnejadmojarad T, Roghani M. Diosgenin ameliorates cellular and molecular changes in multiple sclerosis in C57BL/6 mice. Mult Sclerosis Related Disord 2021;55:103211.

Article  CAS  Google Scholar 

Ge Y, Ding S, Feng J, et al. Diosgenin inhibits Wnt/β-catenin pathway to regulate the proliferation and differentiation of MG-63 cells. Cytotechnology 2021;73:169–178.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li B, Xu P, Wu S, et al. Diosgenin attenuates lipopolysaccharide-induced Parkinson’s disease by inhibiting the TLR/NF-κ B pathway. J Alzheimer’s Dis 2018;64:943–955.

Article  CAS  Google Scholar 

Tohda C, Urano T, Umezaki M, et al. Diosgenin is an exogenous activator of 1,25D-MARRS/Pdia3/ERp57 and improves Alzheimer’s disease pathologies in 5XFAD mice. Sci Rep 2012;2:535.

Article  PubMed  PubMed Central  Google Scholar 

Ahmed LA, Obaid AA, Zaki HF, et al. Role of oxidative stress, inflammation, nitric oxide and transforming growth factor-beta in the protective effect of diosgenin in monocrotaline-induced pulmonary hypertension in rats. Eur J Pharmacol 2014;740:379–387.

Article  CAS  PubMed  Google Scholar 

Zígolo MA, Goytia MR, Poma HR, et al. Virtual screening of plant-derived compounds against SARS-CoV-2 viral proteins using computational tools. Sci Total Environ 2021;781:146400.

Article  PubMed  PubMed Central  Google Scholar 

Yu H, Liu Y, Niu C, et al. Diosgenin increased DDX3 expression in hepatocellular carcinoma. Am J Transl Res 2018;10:3590–3599.

CAS  PubMed  PubMed Central  Google Scholar 

Nazir R, Gupta S, Dey A, et al. In vitro propagation and assessment of genetic fidelity in Dioscorea deltoidea, a potent diosgenin yielding endangered plant. South Afr J Botany 2021;140:349–355.

Article  CAS  Google Scholar 

Handschel J, Naujoks C, Depprich RA, et al. CT-scan is a valuable tool to detect mandibular involvement in oral cancer patients. Oral Oncol 2012;48:361–366.

Article  PubMed  Google Scholar 

Zhang LW, Li J, Cong X, et al. Incidence and mortality trends in oral and oropharyngeal cancers in China, 2005–2013. Cancer Epidemiol 2018;57:120–126.

Article  PubMed  Google Scholar 

Kaneko T, Dehari H, Sasaki T, et al. Hypoxia-induced epithelial-mesenchymal transition is regulated by phosphorylation of GSK3-β via PI3K/Akt signaling in oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol 2016;122:719–730.

Article  PubMed  Google Scholar 

Pons-Fuster Lopez E, Wang QT, Wei W, et al. Potential chemotherapeutic effects of diosgenin, zoledronic acid and epigallocatechin-3-gallate on PE/CA-PJ15 oral squamous cancer cell line. Arch Oral Biol 2017;82:141–146.

Article  CAS  PubMed  Google Scholar 

Rajalingam K, Sugunadevi G, Arokia Vijayaanand M, et al. Anti-tumour and anti-oxidative potential of diosgenin against 7,12-dimethylbenz(a) anthracene induced experimental oral carcinogenesis. Pathol Oncol Res 2012;18:405–412.

Article  CAS  PubMed  Google Scholar 

Lin J, Tan YF, Ma TL, et al. Diosgenin regulates proliferation, apoptosis, migration and invasion of human esophageal cancer Eca109 cells via the MAPK signaling pathway. World Chin J Digestol (Chin) 2013;21:3977–3982.

Article  CAS  Google Scholar 

Ding W, Jiang Y, Jiang Y, et al. Role of SB203580 in the regulation of human esophageal cancer cells under the effection of diosgenin. Int J Clin Exp Med 2015;8:2476–2479.

CAS  PubMed  PubMed Central  Google Scholar 

Gu L, Zheng H, Zhao R, et al. Diosgenin inhibits the proliferation of gastric cancer cells via inducing mesoderm posterior 1 down-regulation-mediated alternative reading frame expression. Human Exp Toxicol 2021;40:S632–S645.

Article  CAS  Google Scholar 

Mao ZJ, Tang QJ, Zhang CA, et al. Anti-proliferation and anti-invasion effects of diosgenin on gastric cancer BGC-823 cells with HIF-1 α shRNAs. Int J Mol Sci 2012;13:6521–6533.

Article  CAS  PubMed  PubMed Central  Google Scholar 

He ZM, Zhang XT, Wang TC. Diosgenin-induced apoptosis dependent on caspase-3 pathway on MGC-803 cells. Chin J Lab Diagnos (Chin) 2011;15:1813–1815.

Google Scholar 

Liu S, Rong G, Li X, et al. Diosgenin and GSK126 produce synergistic effects on epithelial-mesenchymal transition in gastric cancer cells by mediating EZH2 via the Rho/ROCK signaling pathway. OncoTargets Ther 2020;13:5057–5067.

Article  CAS  Google Scholar 

Li SY, Shang J, Mao XM, et al. Diosgenin exerts anti-tumor effects through inactivation of cAMP/PKA/CREB signaling pathway in colorectal cancer. Eur J Pharmacol 2021;908:174370.

Article  CAS  PubMed  Google Scholar 

Lepage C, Liagre B, Cook-Moreau J, et al. Cyclooxygenase-2 and 5-lipoxygenase pathways in diosgenin-induced apoptosis in HT-29 and HCT-116 colon cancer cells. Int J Oncol 2010;36:1183–1191.

CAS  PubMed  Google Scholar 

Khathayer F, Ray SK. Diosgenin as a novel alternative therapy for inhibition of growth, invasion, and angiogenesis abilities of different glioblastoma cell lines. Neurochem Res 2020;45:2336–2351.

Article  CAS  PubMed  Google Scholar 

Raju J, Patlolla JM, Swamy MV, et al. Diosgenin, a steroid saponin of Trigonella foenum graecum (Fenugreek), inhibits azoxymethane-induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT-29 human colon cancer cells. Cancer Epidemiol Biomark Prev 2004;13:1392–1398.

Article  CAS  Google Scholar 

Raju J, Bird RP. Diosgenin, a naturally occurring steroid saponin suppresses 3-hydroxy-3-methylglutaryl CoA reductase expression and induces apoptosis in HCT-116 human colon carcinoma cells. Cancer Letters 2007;255:194–204.

Article  CAS  PubMed  Google Scholar 

Li Y, Wang X, Cheng S, et al. Diosgenin induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma cells. Oncol Rep 2015;33:693–698.

Article  CAS  PubMed  Google Scholar 

Chen Z, Xu J, Wu Y, et al. Diosgenin inhibited the expression of TAZ in hepatocellular carcinoma. Biochem Biophys Res Commun 2018;503:1181–1185.

Article  CAS  PubMed  Google Scholar 

Liu XJ, Tan YH, Wu YY, et al. Inhibition and induction of apoptosis effects of diosgenin on rat hepatoma cells CBRH7919. Chin J Modern Med (Chin) 2010;20:980–983.

CAS  Google Scholar 

Guo W, Chen Y, Gao J, et al. Diosgenin exhibits tumor suppressive function via down-regulation of EZH2 in pancreatic cancer cells. Cell Cycle 2019;18:1745–1758.

Article  CAS  PubM

留言 (0)

沒有登入
gif