Nanosuspensions technology as a master key for nature products drug delivery and In vivo fate

Elsevier

Available online 18 March 2023, 106425

European Journal of Pharmaceutical SciencesAuthor links open overlay panel, , , Abstract

The drug nanosuspensions is a universal formulation approach for improved drug delivery of hydrophobic drugs and one the most promising approaches for increasing the biopharmaceutical performance of poorly water-soluble drug substances, especially for nature products. This review aimed to summarize the nanosuspensions preparation approaches and the main technological difficulties encountered in nanosuspensions development, such as guidelines for stabilizers screening, in vivo fate of the intravenously administrated nanosuspensions, and how to realize the intravenously target delivery was reviewed. Furthermore, challenges of nanosuspensions for the nature products delivery also was discussed and commented. Therefore, it hoped to provide reference and assistance for the nanosuspensions production, stabilizers usage, and predictability of in vivo fate and controllability of targeting delivery of the nature products nanosuspensions.

Graphical abstract

The graphical influence of the formulation properties on the curcumin nanosuspensions penetration targeting efficacy exhibited that all the nanosuspensions loaded gels, independent on type and concentration of the gelling agent used, presented an efficient uptake of the nanosuspensions into the hair follicles. Aqueous nanosuspensions (aqueous NS), Polyacrylic acid (PAA), Hydrogels hydroxyethyl cellulose (HEC). Magnification: 100 fold and 100 µm of the scale.

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Key words

Nanosuspensions

Nanocrystals

Nature products

In vivo fate

Target drug delivery

Data Availability

No data was used for the research described in the article.

© 2023 The Author(s). Published by Elsevier B.V.

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