Johnson AK, Hayes SN, Sawchuk C, Johnson MP, Best PJ, Gulati R, Tweet MS. Analysis of posttraumatic stress disorder, depression, anxiety, and resiliency within the unique population of spontaneous coronary artery dissection survivors. J Am Heart Assoc. 2020;9:e014372.

Article  PubMed  PubMed Central  Google Scholar 

Mostofsky E, Penner EA, Mittleman MA. Outbursts of anger as a trigger of acute cardiovascular events: a systematic review and meta-analysis. Eur Heart J. 2014;35:1404–10. https://doi.org/10.1093/eurheartj/ehu033.

Article  PubMed  PubMed Central  Google Scholar 

Shah AS, Alonso A, Whitsel EA, Soliman EZ, Vaccarino V, Shah AJ. Association of psychosocial factors with short-term resting heart rate variability: the atherosclerosis risk in communities study. J Am Heart Assoc. 2021;10:e017172.

Article  PubMed  PubMed Central  Google Scholar 

Gustad LT, Laugsand LE, Janszky I, Dalen H, Bjerkeset O. Symptoms of anxiety and depression and risk of heart failure: the HUNT Study. Eur J Heart Fail. 2014;16:861–70. https://doi.org/10.1002/ejhf.133.

Article  PubMed  Google Scholar 

Oka T. Shitsu-taikan-sho (alexisomia): a historical review and its clinical importance. Biopsychosoc Med. 2020;14:23. https://doi.org/10.1186/s13030-020-00193-9.

Article  PubMed  PubMed Central  Google Scholar 

Falkner AL, Grosenick L, Davidson TJ, Deisseroth K, Lin D. Hypothalamic control of male aggression-seeking behavior. Nat Neurosci. 2016;19:596–604. https://doi.org/10.1038/nn.4264.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mendes-Gomes J, Motta SC, Passoni Bindi R, de Oliveira AR, Ullah F, Baldo MVC, Coimbra NC, Canteras NS, Blanchard DC. Defensive behaviors and brain regional activation changes in rats confronting a snake. Behav Brain Res. 2020;381:112469.

Article  PubMed  Google Scholar 

Viskaitis P, Irvine EE, Smith MA, Choudhury AI, Alvarez-Curto E, Glegola JA, Hardy DG, Pedroni SMA, Paiva Pessoa MR, Fernando ABP, et al. Modulation of SF1 Neuron Activity Coordinately Regulates Both Feeding Behavior and Associated Emotional States. Cell Rep. 2017;21:3559–72. https://doi.org/10.1016/j.celrep.2017.11.089.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bachman SL, Nashiro K, Yoo H, Wang D, Thayer JF, Mather M. Associations between locus coeruleus MRI contrast and physiological responses to acute stress in younger and older adults. Brain Res. 2022;1796:148070.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kataoka N, Hioki H, Kaneko T, Nakamura K. Psychological stress activates a dorsomedial hypothalamus-medullary raphe circuit driving brown adipose tissue thermogenesis and hyperthermia. Cell Metab. 2014;20:346–58. https://doi.org/10.1016/j.cmet.2014.05.018.

Article  CAS  PubMed  Google Scholar 

James C, Macefield VG, Henderson LA. Real-time imaging of cortical and subcortical control of muscle sympathetic nerve activity in awake human subjects. Neuroimage. 2013;70:59–65. https://doi.org/10.1016/j.neuroimage.2012.12.047.

Article  PubMed  Google Scholar 

Suzuki Y, Shimizu H, Ishizuka N, Kubota N, Kubota T, Senoo A, Kageyama H, Osaka T, Hirako S, Kim HJ, et al. Vagal hyperactivity due to ventromedial hypothalamic lesions increases adiponectin production and release. Diabetes. 2014;63:1637–48. https://doi.org/10.2337/db13-0636.

Article  CAS  PubMed  Google Scholar 

Meng G, Zhou X, Wang M, Zhou L, Wang Z, Wang M, Deng J, Wang Y, Zhou Z, Zhang Y, et al. Gut microbe-derived metabolite trimethylamine N-oxide activates the cardiac autonomic nervous system and facilitates ischemia-induced ventricular arrhythmia via two different pathways. EBioMedicine. 2019. https://doi.org/10.1016/j.ebiom.2019.03.066.

Article  PubMed  PubMed Central  Google Scholar 

Yu L, Zhou L, Cao G, Po SS, Huang B, Zhou X, Wang M, Yuan S, Wang Z, Wang S, et al. Optogenetic modulation of cardiac sympathetic nerve activity to prevent ventricular arrhythmias. J Am Coll Cardiol. 2017;70:2778–90. https://doi.org/10.1016/j.jacc.2017.09.1107.

Article  PubMed  Google Scholar 

Lai Y, Zhou X, Guo F, Jin X, Meng G, Zhou L, Chen H, Liu Z, Yu L, Jiang H. Non-invasive transcutaneous vagal nerve stimulation improves myocardial performance in doxorubicin-induced cardiotoxicity. Cardiovasc Res. 2021. https://doi.org/10.1093/cvr/cvab209.

Article  PubMed  PubMed Central  Google Scholar 

Polhemus DJ, Gao J, Scarborough AL, Trivedi R, McDonough KH, Goodchild TT, Smart F, Kapusta DR, Lefer DJ. Radiofrequency Renal Denervation Protects the Ischemic Heart via Inhibition of GRK2 and Increased Nitric Oxide Signaling. Circ Res. 2016;119:470–80. https://doi.org/10.1161/CIRCRESAHA.115.308278.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dias DA, Silva VJ, Tobaldini E, Rocchetti M, Wu MA, Malfatto G, Montano N, Zaza A. Modulation of sympathetic activity and heart rate variability by ivabradine. Cardiovasc Res. 2015;108:31–8.

Article  Google Scholar 

Yu L, Meng G, Huang B, Zhou X, Stavrakis S, Wang M, Li X, Zhou L, Wang Y, Wang M, et al. A potential relationship between gut microbes and atrial fibrillation: Trimethylamine N-oxide, a gut microbe-derived metabolite, facilitates the progression of atrial fibrillation. Int J Cardiol. 2018;255:92–8. https://doi.org/10.1016/j.ijcard.2017.11.071.

Article  PubMed  Google Scholar 

Li Z, Li Y, He Z, Li Z, Xu W, Xiang H. The preventive effect of cardiac sympathetic denervation induced by 6-OHDA on myocardial ischemia-reperfusion injury: the changes of lncRNA/circRNAs-miRNA-mRNA network of the upper thoracic spinal cord in rats. Oxid Med Cell Longev. 2021;2021:2492286. https://doi.org/10.1155/2021/2492286.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barth AL, Gerkin RC, Dean KL. Alteration of neuronal firing properties after in vivo experience in a FosGFP transgenic mouse. J Neurosci. 2004;24:6466–75. https://doi.org/10.1523/JNEUROSCI.4737-03.2004.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Granger DN, Kvietys PR. Reperfusion injury and reactive oxygen species: The evolution of a concept. Redox Biol. 2015;6:524–51. https://doi.org/10.1016/j.redox.2015.08.020.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Takaoka A, Yanai H, Kondo S, Duncan G, Negishi H, Mizutani T, Kano S, Honda K, Ohba Y, Mak TW, et al. Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors. Nature. 2005;434:243–9. https://doi.org/10.1038/nature03308.

Article  CAS  PubMed  Google Scholar 

Sakurai K, Zhao S, Takatoh J, Rodriguez E, Lu J, Leavitt AD, Fu M, Han BX, Wang F. Capturing and Manipulating Activated Neuronal Ensembles with CANE Delineates a Hypothalamic Social-Fear Circuit. Neuron. 2016;92:739–53. https://doi.org/10.1016/j.neuron.2016.10.015.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shao J, Gao DS, Liu YH, Chen SP, Liu N, Zhang L, Zhou XY, Xiao Q, Wang LP, Hu HL, et al. Cav31-driven bursting firing in ventromedial hypothalamic neurons exerts dual control of anxiety-like behavior and energy expenditure. Mol Psychiatry. 2022. https://doi.org/10.1038/s41380-022-01513-x.

Article  PubMed  PubMed Central  Google Scholar 

Jia F, Li L, Liu H, Lv P, Shi X, Wu Y, Ling C, Xu F. Development of a rabies virus-based retrograde tracer with high trans-monosynaptic efficiency by reshuffling glycoprotein. Mol Brain. 2021;14:109. https://doi.org/10.1186/s13041-021-00821-7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pyner S. The paraventricular nucleus and heart failure. Exp Physiol. 2014;99:332–9. https://doi.org/10.1113/expphysiol.2013.072678.

Article  CAS  PubMed  Google Scholar 

Wang FB, Cheng PM, Chi HC, Kao CK, Liao YH. Axons of Passage and Inputs to Superior Cervical Ganglion in Rat. Anat Rec (Hoboken). 2018;301:1906–16. https://doi.org/10.1002/ar.23953.

Article  CAS  PubMed  Google Scholar 

Shi Y, Li Y, Yin J, Hu H, Xue M, Li X, Cheng W, Wang Y, Li X, Wang Y, et al. A novel sympathetic neuronal GABAergic signalling system regulates NE release to prevent ventricular arrhythmias after acute myocardial infarction. Acta Physiol. 2019;227:e13315.

Article  Google Scholar 

Lindberg D, Chen P, Li C. Conditional viral tracing reveals that steroidogenic factor 1-positive neurons of the dorsomedial subdivision of the ventromedial hypothalamus project to autonomic centers of the hypothalamus and hindbrain. J Comp Neurol. 2013;521:3167–90. https://doi.org/10.1002/cne.23338.

Article  CAS  PubMed  Google Scholar 

Lim K, Barzel B, Burke SL, Armitage JA, Head GA. Origin of aberrant blood pressure and sympathetic regulation in diet-induced obesity. Hypertension. 2016;68:491–500. https://doi.org/10.1161/HYPERTENSIONAHA.116.07461.

Article  CAS  PubMed  Google Scholar 

Priori SG, Blomstrom-Lundqvist C, Mazzanti A, Blom N, Borggrefe M, Camm J, Elliott PM, Fitzsimons D, Hatala R, Hindricks G, et al. ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: the task force for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death of the European Society of Cardiology (ESC). Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC). Eur Heart J. 2015;36:2793–867.

Article  PubMed  Google Scholar 

Chen M, Zhou X, Yu L, Liu Q, Sheng X, Wang Z, Wang S, Jiang H, Zhou S. Low-Level vagus nerve stimulation attenuates myocardial ischemic reperfusion injury by antioxidative stress and antiapoptosis reactions in canines. J Cardiovasc Electrophysiol. 2016;27:224–31. https://doi.org/10.1111/jce.12850.

Article  PubMed  Google Scholar 

Hasham MG, Baxan N, Stuckey DJ, Branca J, Perkins B, Dent O, Duffy T, Hameed TS, Stella SE, Bellahcene M, et al. Systemic autoimmunity induced by the TLR7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy in a new mouse model of autoimmune heart disease. Dis Model Mech. 2017;10:259–70. https://doi.org/10.1242/dmm.027409.

Article  CAS  PubMed  PubMed Central