Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, Bigner SH, Giovanella BC, Ittmann M, Tycko B, Hibshoosh H, Wigler MH, Parsons R. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science. 1997;275(5308):1943–7. https://doi.org/10.1126/science.275.5308.1943. (PMID: 9072974).
Article CAS PubMed Google Scholar
Eng C. PTEN: one gene, many syndromes. Hum Mutat. 2003;22(3):183–98. https://doi.org/10.1002/humu.10257. (PMID: 12938083).
Article CAS PubMed Google Scholar
Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH, Langford LA, Baumgard ML, Hattier T, Davis T, Frye C, Hu R, Swedlund B, Teng DH, Tavtigian SV. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet. 1997;15(4):356–62. https://doi.org/10.1038/ng0497-356. (PMID: 9090379).
Article CAS PubMed Google Scholar
Myers MP, Pass I, Batty IH, Van der Kaay J, Stolarov JP, Hemmings BA, Wigler MH, Downes CP, Tonks NK. The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proc Natl Acad Sci USA. 1998;95(23):13513–8. https://doi.org/10.1073/pnas.95.23.13513.PMID:9811831;PMCID:PMC24850.
Article CAS PubMed PubMed Central Google Scholar
Stambolic V, Suzuki A, de la Pompa JL, Brothers GM, Mirtsos C, Sasaki T, Ruland J, Penninger JM, Siderovski DP, Mak TW. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell. 1998;95(1):29–39. https://doi.org/10.1016/s0092-8674(00)81780-8. (PMID: 9778245).
Article CAS PubMed Google Scholar
Shen WH, Balajee AS, Wang J, Wu H, Eng C, Pandolfi PP, Yin Y. Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell. 2007;128(1):157–70. https://doi.org/10.1016/j.cell.2006.11.042. (PMID: 17218262).
Article CAS PubMed Google Scholar
Bassi C, Ho J, Srikumar T, Dowling RJ, Gorrini C, Miller SJ, Mak TW, Neel BG, Raught B, Stambolic V. Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress. Science. 2013;341(6144):395–9. https://doi.org/10.1126/science.1236188.Erratum.In:Science.2013Sep6;341(6150):1064.PMID:23888040;PMCID:PMC5087104.
Article CAS PubMed PubMed Central Google Scholar
Hou SQ, Ouyang M, Brandmaier A, Hao H, Shen WH. PTEN in the maintenance of genome integrity: From DNA replication to chromosome segregation. BioEssays. 2017;39(10):1700082. https://doi.org/10.1002/bies.201700082.
Brandmaier A, Hou SQ, Shen WH. Cell cycle control by PTEN. J Mol Biol. 2017;429(15):2265–77. https://doi.org/10.1016/j.jmb.2017.06.004.
Article CAS PubMed PubMed Central Google Scholar
Mansour WY, Tennstedt P, Volquardsen J, Oing C, Kluth M, Hube-Magg C, Borgmann K, Simon R, Petersen C, Dikomey E, Rothkamm K. Loss of PTEN-assisted G2/M checkpoint impedes homologous recombination repair and enhances radio-curability and PARP inhibitor treatment response in prostate cancer. Sci Rep. 2018;8(1):3947. https://doi.org/10.1038/s41598-018-22289-7.PMID:29500400;PMCID:PMC5834544.
Article CAS PubMed PubMed Central Google Scholar
He J, Kang X, Yin Y, Chao KS, Shen WH. PTEN regulates DNA replication progression and stalled fork recovery. Nat Commun. 2015;9(6):7620. https://doi.org/10.1038/ncomms8620.PMID:26158445;PMCID:PMC4499867.
Sun Z, Lu J, Wu M, Li M, Bai L, Shi Z, Hao L, Wu Y. Deficiency of PTEN leads to aberrant chromosome segregation through downregulation of MAD2. Mol Med Rep. 2019;20(5):4235–43. https://doi.org/10.3892/mmr.2019.10668.
Article CAS PubMed PubMed Central Google Scholar
Yuen KW, Montpetit B, Hieter P. The kinetochore and cancer: what’s the connection? Curr Opin Cell Biol. 2005;17(6):576–82. https://doi.org/10.1016/j.ceb.2005.09.012. (Epub 2005 Oct 17 PMID: 16233975).
Article CAS PubMed Google Scholar
Puc J, Keniry M, Li HS, Pandita TK, Choudhury AD, Memeo L, Mansukhani M, Murty VV, Gaciong Z, Meek SE, Piwnica-Worms H, Hibshoosh H, Parsons R. Lack of PTEN sequesters CHK1 and initiates genetic instability. Cancer Cell. 2005;7(2):193–204. https://doi.org/10.1016/j.ccr.2005.01.009. (PMID: 15710331).
Article CAS PubMed Google Scholar
Sun Z, Huang C, He J, Lamb KL, Kang X, Gu T, Shen WH, Yin Y. PTEN C-terminal deletion causes genomic instability and tumor development. Cell Rep. 2014;6(5):844–54. https://doi.org/10.1016/j.celrep.2014.01.030.
Article CAS PubMed PubMed Central Google Scholar
Vazquez F, Grossman SR, Takahashi Y, Rokas MV, Nakamura N, Sellers WR. Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex. J Biol Chem. 2001;276(52):48627–30. https://doi.org/10.1074/jbc.C100556200. (Epub 2001 Nov 13 PMID: 11707428).
Article CAS PubMed Google Scholar
Lang V, Aillet F, Da Silva-Ferrada E, Xolalpa W, Zabaleta L, Rivas C, Rodriguez MS. Analysis of PTEN ubiquitylation and SUMOylation using molecular traps. Methods. 2015;77–78:112–8. https://doi.org/10.1016/j.ymeth.2014.09.001. (Epub 2014 Sep 16 PMID: 25224693).
Article CAS PubMed Google Scholar
Meng Z, Jia LF, Gan YH. PTEN activation through K163 acetylation by inhibiting HDAC6 contributes to tumour inhibition. Oncogene. 2016;35(18):2333–44. https://doi.org/10.1038/onc.2015.293. (Epub 2015 Aug 17 PMID: 26279303).
Article CAS PubMed Google Scholar
Zhang Y, Park J, Han SJ, Yang SY, Yoon HJ, Park I, Woo HA, Lee SR. Redox regulation of tumor suppressor PTEN in cell signaling. Redox Biol. 2020;34:101553. https://doi.org/10.1016/j.redox.2020.101553.
Article CAS PubMed PubMed Central Google Scholar
Choi BH, Pagano M, Dai W. Plk1 protein phosphorylates phosphatase and tensin homolog (PTEN) and regulates its mitotic activity during the cell cycle. J Biol Chem. 2014;289(20):14066–74. https://doi.org/10.1074/jbc.M114.558155.
Article CAS PubMed PubMed Central Google Scholar
Al-Khouri AM, Ma Y, Togo SH, Williams S, Mustelin T. Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3beta. J Biol Chem. 2005;280(42):35195–202. https://doi.org/10.1074/jbc.M503045200. (Epub 2005 Aug 17 PMID: 16107342).
Article CAS PubMed Google Scholar
Vazquez F, Ramaswamy S, Nakamura N, Sellers WR. Phosphorylation of the PTEN tail regulates protein stability and function. Mol Cell Biol. 2000;20(14):5010–8. https://doi.org/10.1128/mcb.20.14.5010-5018.2000.PMID:10866658;PMCID:PMC85951.
Article CAS PubMed PubMed Central Google Scholar
Torres J, Pulido R. The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus: implications for PTEN stability to proteasome-mediated degradation. J Biol Chem. 2001;276(2):993–8. https://doi.org/10.1074/jbc.M009134200. (PMID: 11035045).
Article CAS PubMed Google Scholar
Ginn-Pease ME, Eng C. Increased nuclear phosphatase and tensin homologue deleted on chromosome 10 is associated with G0–G1 in MCF-7 cells. Cancer Res. 2003;63(2):282–6 (PMID: 12543774).
Sun H, Lesche R, Li DM, Liliental J, Zhang H, Gao J, Gavrilova N, Mueller B, Liu X, Wu H. PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci USA. 1999;96(11):6199–204. https://doi.org/10.1073/pnas.96.11.6199.PMID:10339565;PMCID:PMC26859.
Article CAS PubMed PubMed Central Google Scholar
Ma J, Benitez JA, Li J, Miki S, Ponte de Albuquerque C, Galatro T, Orellana L, Zanca C, Reed R, Boyer A, Koga T, Varki NM, Fenton TR, Nagahashi Marie SK, Lindahl E, Gahman TC, Shiau AK, Zhou H, DeGroot J, Sulman EP, Cavenee WK, Kolodner RD, Chen CC, Furnari FB. Inhibition of nuclear PTEN tyrosine phosphorylation enhances glioma radiation sensitivity through attenuated DNA repair. Cancer Cell. 2019;35(3):504–18.e7. doi: https://doi.org/10.1016/j.ccell.2019.01.020. Epub 2019 Feb 28. Erratum in: Cancer Cell. 2019 May 13;35(5):816. Erratum in: Cancer Cell. 2019 Dec 9;36(6):690–91. PMID: 30827889; PMCID: PMC6424615.
Misra S, Chowdhury SG, Ghosh G, Mukherjee A, Karmakar P. Both phosphorylation and phosphatase activity of PTEN are required to prevent replication fork progression during stress by inducing heterochromatin. Mutation Res/Fundamental Mol Mech Mutagen. 2022;825:111800. https://doi.org/10.1016/j.mrfmmm.2022.111800.
Barr FA, Silljé HH, Nigg EA. Polo-like kinases and the orchestration of cell division. Nat Rev Mol Cell Biol. 2004;5(6):429–40. https://doi.org/10.1038/nrm1401. (PMID: 15173822).
Article CAS PubMed Google Scholar
Strebhardt K. Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy. Nat Rev Drug Discov. 2010;9(8):643–60. https://doi.org/10.1038/nrd3184. (PMID: 20671765).
Article CAS PubMed Google Scholar
Liu X, Erikson RL. Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells. Proc Natl Acad Sci USA. 2003;100(10):5789–94. https://doi.org/10.1073/pnas.1031523100.
Article CAS PubMed PubMed Central Google Scholar
Smits VA, Klompmaker R, Arnaud L, Rijksen G, Nigg EA, Medema RH. Polo-like kinase-1 is a target of the DNA damage checkpoint. Nat Cell Biol. 2000;2(9):672–6. https://doi.org/10.1038/35023629. (PMID: 10980711).
Article CAS PubMed Google Scholar
Liu XS, Li H, Song B, Liu X. Polo-like kinase 1 phosphorylation of G2 and S-phase-expressed 1 protein is essential for p53 inactivation during G2 checkpoint recovery. EMBO Rep. 2010;11(8):626–32. https://doi.org/10.1038/embor.2010.90.
Article CAS PubMed PubMed Central Google Scholar
Bassermann F, Frescas D, Guardavaccaro D, Busino L, Peschiaroli A, Pagano M. The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint. Cell. 2008;134(2):256–67. https:/
留言 (0)