Discovery of orally effective and safe GPR40 agonists by incorporating a chiral, rigid and polar sulfoxide into β-position to the carboxylic acid
Keywords
GPR40
Glucose-stimulated insulin secretion
Type 2 diabetes mellitus
Lipophilicity
Liver safety
Three-in-one pharmacophore
2-(phenylsulfinyl)acetic acid
Data availability
No data was used for the research described in the article.
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