The Clinical Application of Optimized AT(N) Classification in Alzheimer’s Clinical Syndrome (ACS) and non-ACS Conditions

AbbreviationsACS

Alzheimer’s clinical syndrome

CAA

cerebral amyloid angiopathy

DMT

disease modifying therapy

FTLD

frontotemporal lobar degeneration

GMM

Gaussian mixture models

iNPH

idiopathic normal pressure hydrocephalus

J-ADNI

Japanese Alzheimer’s Disease Neuroimaging Initiative

MCI

mild cognitive impairment

MSA

multiple system atrophy

NfL

neurofilament light chain

PPA

primary progressive aphasia

PET

positron emission tomography

PSP

progressive supranuclear palsy

VCI

vascular cognitive impairment

Keywords

Cerebrospinal fluid (CSF)

Biomarker

AT(N) classification

Alzheimer’s clinical syndrome

Aβ42/Aβ40 ratio

Neurofilament light (NfL)

Availability of data and materials

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

© 2023 The Author(s). Published by Elsevier Inc.

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